SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o5a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)		 3o5a PERIPLASMIC NITRATE
REDUCTASE
(Cupriavidus
necator) 		3 / 3 ALA A 500
VAL A 503
TRP A 519
 None
 0.99A 1c4dA-3o5aA:
undetectable
1c4dB-3o5aA:
undetectable		 1c4dA-3o5aA:
2.86
1c4dB-3o5aA:
2.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 3o5a PERIPLASMIC NITRATE
REDUCTASE
(Cupriavidus
necator) 		3 / 3 TRP A 519
ALA A 500
VAL A 503
 None
 0.96A 1c4dA-3o5aA:
undetectable
1c4dB-3o5aA:
undetectable		 1c4dA-3o5aA:
2.86
1c4dB-3o5aA:
2.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)		 3o5a PERIPLASMIC NITRATE
REDUCTASE
(Cupriavidus
necator) 		4 / 6 PHE A 769
LEU A 711
VAL A  55
VAL A 695
 None
 1.00A 1e7aB-3o5aA:
undetectable		 1e7aB-3o5aA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3o5a PERIPLASMIC NITRATE
REDUCTASE
(Cupriavidus
necator) 		5 / 12 GLY A  57
LEU A  60
GLY A  42
LEU A 522
VAL A 503
 SF4  A1801 (-3.6A)
None
None
None
None
 0.90A 1fduA-3o5aA:
2.2		 1fduA-3o5aA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 3o5a PERIPLASMIC NITRATE
REDUCTASE
(Cupriavidus
necator) 		5 / 12 GLY A 229
MET A 240
SER A 319
LEU A 326
ILE A 228
 None
 1.28A 1lhuA-3o5aA:
undetectable		 1lhuA-3o5aA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 3o5a PERIPLASMIC NITRATE
REDUCTASE
DIHEME CYTOCHROME C
NAPB
(Cupriavidus
necator;
Cupriavidus
necator) 		4 / 8 HIS A 698
SER A 714
ARG A 713
VAL B 103
 None
 1.21A 1u1jA-3o5aA:
undetectable		 1u1jA-3o5aA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 3o5a PERIPLASMIC NITRATE
REDUCTASE
(Cupriavidus
necator) 		3 / 3 ASP A 617
GLU A 415
ARG A 400
 None
None
FMT  A 803 (-4.0A)
 0.88A 1wopA-3o5aA:
undetectable		 1wopA-3o5aA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3o5a DIHEME CYTOCHROME C
NAPB
PERIPLASMIC NITRATE
REDUCTASE
(Cupriavidus
necator) 		4 / 5 PHE A 715
LEU B  21
PHE A 769
SER A 772
 None
 1.14A 1wrkB-3o5aA:
undetectable		 1wrkB-3o5aA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3o5a DIHEME CYTOCHROME C
NAPB
PERIPLASMIC NITRATE
REDUCTASE
(Cupriavidus
necator) 		4 / 7 PHE A 715
LEU B  21
PHE A 769
SER A 772
 None
 1.07A 1wrlA-3o5aA:
undetectable
1wrlB-3o5aA:
undetectable		 1wrlA-3o5aA:
8.22
1wrlB-3o5aA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 3o5a PERIPLASMIC NITRATE
REDUCTASE
(Cupriavidus
necator) 		3 / 3 PHE A 518
VAL A 126
TRP A 127
 None
 0.87A 2cc8A-3o5aA:
undetectable		 2cc8A-3o5aA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 3o5a PERIPLASMIC NITRATE
REDUCTASE
(Cupriavidus
necator) 		3 / 3 PHE A 518
VAL A 126
TRP A 127
 None
 0.88A 2ccbA-3o5aA:
undetectable		 2ccbA-3o5aA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 3o5a PERIPLASMIC NITRATE
REDUCTASE
(Cupriavidus
necator) 		5 / 12 ASN A 511
GLY A 629
PHE A 604
GLY A 389
VAL A 126
 None
 1.43A 2fqyA-3o5aA:
2.2		 2fqyA-3o5aA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_1
(ESTROGEN RECEPTOR)		 3o5a DIHEME CYTOCHROME C
NAPB
PERIPLASMIC NITRATE
REDUCTASE
(Cupriavidus
necator) 		5 / 12 THR B  10
LEU A 491
ARG A  76
MET A 465
LEU A 774
 None
FMT  B 139 (-4.5A)
None
None
CL  A 816 (-4.0A)
 1.13A 2jfaA-3o5aB:
undetectable		 2jfaA-3o5aB:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 3o5a PERIPLASMIC NITRATE
REDUCTASE
(Cupriavidus
necator) 		3 / 3 LEU A 497
PRO A 498
ARG A 542
 None
 0.61A 2qd5A-3o5aA:
undetectable		 2qd5A-3o5aA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 3o5a PERIPLASMIC NITRATE
REDUCTASE
(Cupriavidus
necator) 		3 / 3 PHE A 518
VAL A 126
TRP A 127
 None
 0.87A 2vx9A-3o5aA:
undetectable		 2vx9A-3o5aA:
6.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_1
(HYPOTHETICAL PROTEIN
TTHA0223)		 3o5a PERIPLASMIC NITRATE
REDUCTASE
(Cupriavidus
necator) 		4 / 5 GLU A  99
ARG A 106
ASP A  83
ASP A  87
 None
 1.32A 2yqzA-3o5aA:
2.3		 2yqzA-3o5aA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_1
(HYPOTHETICAL PROTEIN
TTHA0223)		 3o5a PERIPLASMIC NITRATE
REDUCTASE
(Cupriavidus
necator) 		4 / 5 GLU A  99
ARG A 106
ASP A  83
ASP A  87
 None
 1.29A 2yqzB-3o5aA:
2.8		 2yqzB-3o5aA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3o5a DIHEME CYTOCHROME C
NAPB
PERIPLASMIC NITRATE
REDUCTASE
(Cupriavidus
necator) 		6 / 11 VAL A 481
ILE B  12
MET A 458
LEU A 442
ILE A 479
THR A 487
 None
None
None
None
None
MGD  A1803 (-4.0A)
 1.40A 3hbbC-3o5aA:
undetectable		 3hbbC-3o5aA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGG_A_CHDA211_0
(CMER)		 3o5a PERIPLASMIC NITRATE
REDUCTASE
(Cupriavidus
necator) 		4 / 7 PHE A 658
PHE A 258
PHE A 164
TYR A 644
 None
 1.41A 3hggA-3o5aA:
undetectable		 3hggA-3o5aA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 3o5a PERIPLASMIC NITRATE
REDUCTASE
(Cupriavidus
necator) 		5 / 11 ASN A 358
LEU A 381
ALA A 179
LEU A 329
THR A 345
 None
None
None
None
MGD  A1804 (-3.7A)
 1.46A 3jwqB-3o5aA:
undetectable
3jwqC-3o5aA:
undetectable		 3jwqB-3o5aA:
17.08
3jwqC-3o5aA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 3o5a PERIPLASMIC NITRATE
REDUCTASE
(Cupriavidus
necator) 		3 / 3 GLU A  99
LEU A 495
ASP A 494
 None
 0.46A 3ko0A-3o5aA:
undetectable		 3ko0A-3o5aA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3o5a PERIPLASMIC NITRATE
REDUCTASE
(Cupriavidus
necator) 		4 / 8 ASN A 358
LEU A 364
SER A 342
ASN A 349
 None
FMT  A 804 (-4.1A)
None
None
 1.13A 3kp2A-3o5aA:
undetectable
3kp2B-3o5aA:
undetectable		 3kp2A-3o5aA:
9.85
3kp2B-3o5aA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		 3o5a PERIPLASMIC NITRATE
REDUCTASE
(Cupriavidus
necator) 		4 / 7 ASP A  98
GLN A  95
GLN A 103
GLU A 101
 None
 0.94A 3l2vA-3o5aA:
undetectable		 3l2vA-3o5aA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3o5a PERIPLASMIC NITRATE
REDUCTASE
(Cupriavidus
necator) 		3 / 3 VAL A 315
SER A 319
LEU A 326
 None
 0.66A 3n8xA-3o5aA:
undetectable		 3n8xA-3o5aA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3o5a PERIPLASMIC NITRATE
REDUCTASE
(Cupriavidus
necator) 		5 / 11 MET A 747
ILE A 799
VAL A 720
VAL A 764
ILE A 775
 None
 0.88A 3rf4A-3o5aA:
undetectable
3rf4C-3o5aA:
undetectable		 3rf4A-3o5aA:
7.29
3rf4C-3o5aA:
7.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3o5a PERIPLASMIC NITRATE
REDUCTASE
(Cupriavidus
necator) 		5 / 11 ILE A 775
MET A 747
ILE A 799
VAL A 720
VAL A 764
 None
 0.88A 3rf4A-3o5aA:
undetectable
3rf4B-3o5aA:
undetectable		 3rf4A-3o5aA:
7.29
3rf4B-3o5aA:
7.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3o5a PERIPLASMIC NITRATE
REDUCTASE
(Cupriavidus
necator) 		5 / 11 ILE A 775
MET A 747
ILE A 799
VAL A 720
VAL A 764
 None
 0.86A 3rf4B-3o5aA:
undetectable
3rf4C-3o5aA:
undetectable		 3rf4B-3o5aA:
7.29
3rf4C-3o5aA:
7.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 3o5a PERIPLASMIC NITRATE
REDUCTASE
(Cupriavidus
necator) 		5 / 12 HIS A 151
GLY A 120
ASN A 457
ALA A 132
PHE A 397
 MGD  A1803 ( 4.6A)
None
None
None
FMT  A 803 (-3.6A)
 0.72A 3vywB-3o5aA:
2.9		 3vywB-3o5aA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 3o5a PERIPLASMIC NITRATE
REDUCTASE
(Cupriavidus
necator) 		5 / 12 HIS A 151
GLY A 120
ASN A 457
ALA A 132
PHE A 397
 MGD  A1803 ( 4.6A)
None
None
None
FMT  A 803 (-3.6A)
 0.71A 3vywC-3o5aA:
2.7		 3vywC-3o5aA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 3o5a PERIPLASMIC NITRATE
REDUCTASE
(Cupriavidus
necator) 		5 / 12 HIS A 151
GLY A 120
ASN A 457
ALA A 132
PHE A 397
 MGD  A1803 ( 4.6A)
None
None
None
FMT  A 803 (-3.6A)
 0.70A 3vywD-3o5aA:
undetectable		 3vywD-3o5aA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 3o5a PERIPLASMIC NITRATE
REDUCTASE
(Cupriavidus
necator) 		4 / 6 GLY A 117
ASN A 144
LEU A 447
ASN A 448
 None
 0.90A 3zqtA-3o5aA:
undetectable		 3zqtA-3o5aA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3o5a PERIPLASMIC NITRATE
REDUCTASE
DIHEME CYTOCHROME C
NAPB
(Cupriavidus
necator;
Cupriavidus
necator) 		5 / 12 ASN A 455
ILE B  12
GLY A 468
ASN A 439
GLN A 438
 MGD  A1803 (-4.9A)
None
None
None
None
 1.48A 4djfA-3o5aA:
undetectable		 4djfA-3o5aA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 3o5a PERIPLASMIC NITRATE
REDUCTASE
(Cupriavidus
necator) 		4 / 7 ILE A 775
GLY A 702
ALA A 718
GLN A 123
 None
None
None
MGD  A1803 (-2.9A)
 0.92A 4g0uB-3o5aA:
2.0		 4g0uB-3o5aA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRQ_C_AVLC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3o5a PERIPLASMIC NITRATE
REDUCTASE
(Cupriavidus
necator) 		4 / 7 PHE A 792
PRO A 147
GLN A 789
PHE A 119
 MGD  A1803 (-3.6A)
None
None
None
 1.43A 4grqA-3o5aA:
undetectable
4grqC-3o5aA:
undetectable		 4grqA-3o5aA:
9.67
4grqC-3o5aA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 3o5a PERIPLASMIC NITRATE
REDUCTASE
(Cupriavidus
necator) 		4 / 8 ASN A 358
ALA A 156
SER A 155
ARG A 392
 None
None
OCS  A 784 ( 3.2A)
None
 1.18A 4ijiF-3o5aA:
undetectable		 4ijiF-3o5aA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3o5a PERIPLASMIC NITRATE
REDUCTASE
(Cupriavidus
necator) 		3 / 3 ASP A 146
ASN A 143
SER A 787
 None
None
OCS  A 784 ( 3.2A)
 0.76A 4obwA-3o5aA:
3.6		 4obwA-3o5aA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 3o5a DIHEME CYTOCHROME C
NAPB
PERIPLASMIC NITRATE
REDUCTASE
(Cupriavidus
necator) 		3 / 3 MET B   6
MET A 458
TYR A 485
 None
 1.16A 4p6xI-3o5aB:
undetectable		 4p6xI-3o5aB:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 3o5a PERIPLASMIC NITRATE
REDUCTASE
(Cupriavidus
necator) 		5 / 12 ALA A 132
GLY A 120
ALA A 449
GLY A 117
TYR A 136
 None
 0.90A 4r29A-3o5aA:
undetectable		 4r29A-3o5aA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3o5a PERIPLASMIC NITRATE
REDUCTASE
(Cupriavidus
necator) 		4 / 8 PHE A 140
SER A 142
ALA A 132
LEU A 135
 None
 1.00A 4rkuA-3o5aA:
undetectable
4rkuJ-3o5aA:
undetectable		 4rkuA-3o5aA:
22.24
4rkuJ-3o5aA:
4.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_1
(ESTROGEN RECEPTOR)		 3o5a DIHEME CYTOCHROME C
NAPB
PERIPLASMIC NITRATE
REDUCTASE
(Cupriavidus
necator) 		5 / 12 THR B  10
LEU A 491
ARG A  76
MET A 465
LEU A 774
 None
FMT  B 139 (-4.5A)
None
None
CL  A 816 (-4.0A)
 1.26A 4xi3D-3o5aB:
undetectable		 4xi3D-3o5aB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 3o5a PERIPLASMIC NITRATE
REDUCTASE
DIHEME CYTOCHROME C
NAPB
(Cupriavidus
necator;
Cupriavidus
necator) 		4 / 6 LEU A 711
CYH B 101
HIS A 698
LEU A 696
 None
HEC  B1129 (-2.1A)
None
None
 1.41A 5hrqD-3o5aA:
undetectable
5hrqG-3o5aA:
undetectable
5hrqH-3o5aA:
undetectable		 5hrqD-3o5aA:
3.25
5hrqG-3o5aA:
3.88
5hrqH-3o5aA:
3.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3o5a PERIPLASMIC NITRATE
REDUCTASE
(Cupriavidus
necator) 		4 / 9 PHE A 765
VAL A 740
ASN A 776
ILE A 775
 None
None
MGD  A1803 (-2.9A)
None
 0.90A 5lg3I-3o5aA:
undetectable		 5lg3I-3o5aA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3o5a PERIPLASMIC NITRATE
REDUCTASE
(Cupriavidus
necator) 		4 / 8 HIS A 151
ASN A 776
LEU A 464
GLY A 468
 MGD  A1803 ( 4.6A)
MGD  A1803 (-2.9A)
None
None
 0.96A 5m8rC-3o5aA:
undetectable		 5m8rC-3o5aA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3o5a PERIPLASMIC NITRATE
REDUCTASE
(Cupriavidus
necator) 		5 / 10 PHE A 140
SER A 142
ALA A 132
LEU A 135
GLY A 139
 None
 1.06A 5oy01-3o5aA:
undetectable
5oy07-3o5aA:
undetectable		 5oy01-3o5aA:
7.31
5oy07-3o5aA:
4.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 3o5a PERIPLASMIC NITRATE
REDUCTASE
(Cupriavidus
necator) 		4 / 6 GLY A 468
GLN A 438
TYR A 450
TYR A 472
 None
 1.24A 6ag0A-3o5aA:
undetectable		 6ag0A-3o5aA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 3o5a PERIPLASMIC NITRATE
REDUCTASE
(Cupriavidus
necator) 		4 / 6 GLY A 468
GLN A 438
TYR A 450
TYR A 472
 None
 1.24A 6ag0C-3o5aA:
undetectable		 6ag0C-3o5aA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_N_PCFN606_0
(CYTOCHROME B)		 3o5a PERIPLASMIC NITRATE
REDUCTASE
(Cupriavidus
necator) 		5 / 12 ALA A  17
TYR A 509
VAL A 503
VAL A 523
TYR A 587
 None
None
None
None
FMT  A 805 (-4.8A)
 1.34A 6hu9N-3o5aA:
undetectable		 6hu9N-3o5aA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3o5a PERIPLASMIC NITRATE
REDUCTASE
DIHEME CYTOCHROME C
NAPB
(Cupriavidus
necator;
Cupriavidus
necator) 		4 / 6 ASP B  84
ARG B  83
GLU A 177
CYH A 172
 None
 1.38A 6mn5D-3o5aB:
undetectable		 6mn5D-3o5aB:
16.54