SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o5c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 3o5c CYTOCHROME C551
PEROXIDASE
(Shewanella
oneidensis) 		5 / 12 ALA A 165
ILE A 118
PRO A 117
LEU A  52
TYR A 149
 None
None
HEM  A 401 (-4.2A)
None
None
 1.10A 1dhfA-3o5cA:
undetectable		 1dhfA-3o5cA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 3o5c CYTOCHROME C551
PEROXIDASE
(Shewanella
oneidensis) 		5 / 12 ALA A 165
ILE A 118
PRO A 117
LEU A  52
TYR A 149
 None
None
HEM  A 401 (-4.2A)
None
None
 1.16A 1dlsA-3o5cA:
undetectable		 1dlsA-3o5cA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 3o5c CYTOCHROME C551
PEROXIDASE
(Shewanella
oneidensis) 		4 / 8 ASP A  72
ASN A  88
ILE A  87
GLY A  79
 None
CA  A 601 (-2.9A)
HEM  A 401 (-4.4A)
HEM  A 401 ( 3.8A)
 1.01A 1meiA-3o5cA:
undetectable		 1meiA-3o5cA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 3o5c CYTOCHROME C551
PEROXIDASE
(Shewanella
oneidensis) 		5 / 12 GLY A  43
PHE A  47
ALA A 162
ASP A 161
TYR A 149
 None
 1.44A 2avdA-3o5cA:
undetectable		 2avdA-3o5cA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 3o5c CYTOCHROME C551
PEROXIDASE
(Shewanella
oneidensis) 		5 / 12 ALA A 165
ILE A 118
PRO A 117
LEU A  52
TYR A 149
 None
None
HEM  A 401 (-4.2A)
None
None
 1.14A 2w3bB-3o5cA:
undetectable		 2w3bB-3o5cA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 3o5c CYTOCHROME C551
PEROXIDASE
(Shewanella
oneidensis) 		5 / 12 ALA A 165
ILE A 118
PRO A 117
LEU A  52
TYR A 149
 None
None
HEM  A 401 (-4.2A)
None
None
 1.10A 2w3mA-3o5cA:
undetectable		 2w3mA-3o5cA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 3o5c CYTOCHROME C551
PEROXIDASE
(Shewanella
oneidensis) 		4 / 6 ARG A 236
GLY A 105
ALA A 107
LEU A  99
 None
 0.93A 3bgdA-3o5cA:
undetectable		 3bgdA-3o5cA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 3o5c CYTOCHROME C551
PEROXIDASE
(Shewanella
oneidensis) 		4 / 4 PRO A 252
THR A 253
GLY A  69
THR A  68
 HEM  A 501 (-4.3A)
None
None
None
 0.77A 3ib1A-3o5cA:
undetectable		 3ib1A-3o5cA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 3o5c CYTOCHROME C551
PEROXIDASE
(Shewanella
oneidensis) 		4 / 5 PHE A 227
MET A 279
ASN A 277
PHE A 247
 None
HEM  A 501 (-2.3A)
None
None
 1.41A 3octA-3o5cA:
undetectable		 3octA-3o5cA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 3o5c CYTOCHROME C551
PEROXIDASE
(Shewanella
oneidensis) 		4 / 5 GLY A 238
LYS A 237
GLU A 234
GLY A 241
 None
 0.99A 3onnA-3o5cA:
undetectable		 3onnA-3o5cA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3o5c CYTOCHROME C551
PEROXIDASE
(Shewanella
oneidensis) 		3 / 3 GLY A  69
THR A 260
ASN A 256
 None
 0.69A 3v4tD-3o5cA:
undetectable		 3v4tD-3o5cA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 3o5c CYTOCHROME C551
PEROXIDASE
(Shewanella
oneidensis) 		4 / 7 PHE A 199
GLY A 214
ILE A 257
LEU A 303
 None
None
HEM  A 501 ( 4.7A)
None
 0.85A 4ejjD-3o5cA:
undetectable		 4ejjD-3o5cA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 3o5c CYTOCHROME C551
PEROXIDASE
(Shewanella
oneidensis) 		5 / 12 GLU A  36
LEU A  42
LYS A  39
ALA A 143
VAL A 154
 None
 0.96A 5kbwB-3o5cA:
undetectable		 5kbwB-3o5cA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3o5c CYTOCHROME C551
PEROXIDASE
(Shewanella
oneidensis) 		5 / 12 ILE A 163
GLY A  43
VAL A 148
ALA A 164
ALA A 114
 HEM  A 401 (-4.4A)
None
None
None
HEM  A 401 ( 4.1A)
 1.11A 5n0oB-3o5cA:
undetectable		 5n0oB-3o5cA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3o5c CYTOCHROME C551
PEROXIDASE
(Shewanella
oneidensis) 		4 / 5 TYR A 180
SER A 189
ALA A 192
GLN A 197
 None
 1.39A 5n4iA-3o5cA:
undetectable		 5n4iA-3o5cA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 3o5c CYTOCHROME C551
PEROXIDASE
(Shewanella
oneidensis) 		3 / 3 ARG A  51
PHE A  47
LEU A 315
 None
 0.93A 5x1bC-3o5cA:
undetectable		 5x1bC-3o5cA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 3o5c CYTOCHROME C551
PEROXIDASE
(Shewanella
oneidensis) 		5 / 7 THR A 160
ILE A 135
THR A 132
TYR A 149
PHE A 145
 None
 1.33A 5zsfA-3o5cA:
undetectable
5zsfB-3o5cA:
undetectable		 5zsfA-3o5cA:
13.38
5zsfB-3o5cA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_B_6T0B913_0
(TOLL-LIKE RECEPTOR 7)		 3o5c CYTOCHROME C551
PEROXIDASE
(Shewanella
oneidensis) 		5 / 9 TYR A 149
PHE A 145
THR A 160
ILE A 135
THR A 132
 None
 1.35A 5zsfA-3o5cA:
0.0
5zsfB-3o5cA:
undetectable		 5zsfA-3o5cA:
13.38
5zsfB-3o5cA:
13.38