SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o5s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3o5s BETA-GLUCANASE
(Bacillus
subtilis) 		5 / 12 PHE A 138
PHE A 148
ALA A 110
ALA A 176
MET A 107
 None
 0.99A 2x2nB-3o5sA:
undetectable		 2x2nB-3o5sA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3o5s BETA-GLUCANASE
(Bacillus
subtilis) 		4 / 7 GLU A  74
PHE A  38
TYR A 172
HIS A 173
 None
 1.01A 4a97A-3o5sA:
undetectable		 4a97A-3o5sA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3o5s BETA-GLUCANASE
(Bacillus
subtilis) 		4 / 7 GLU A  74
PHE A  38
TYR A 172
HIS A 173
 None
 1.05A 4a97D-3o5sA:
undetectable		 4a97D-3o5sA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3o5s BETA-GLUCANASE
(Bacillus
subtilis) 		4 / 6 GLU A  74
PHE A  38
TYR A 172
HIS A 173
 None
 1.02A 4a97E-3o5sA:
undetectable		 4a97E-3o5sA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3o5s BETA-GLUCANASE
(Bacillus
subtilis) 		4 / 5 GLU A  74
PHE A  38
TYR A 172
HIS A 173
 None
 0.97A 4a97J-3o5sA:
undetectable		 4a97J-3o5sA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3o5s BETA-GLUCANASE
(Bacillus
subtilis) 		5 / 12 GLY A  32
GLY A  31
THR A  30
ILE A 207
PHE A  45
 None
 1.25A 4zvmA-3o5sA:
undetectable
4zvmB-3o5sA:
undetectable		 4zvmA-3o5sA:
21.03
4zvmB-3o5sA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 3o5s BETA-GLUCANASE
(Bacillus
subtilis) 		3 / 3 ASN A 228
TYR A 224
CYH A  89
 None
 1.08A 5lsuB-3o5sA:
undetectable		 5lsuB-3o5sA:
27.86