SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o5y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UPF_B_URFB999_1 (URACIL PHOSPHORIBOSYLTRANSF ERASE)	3o5y	SENSOR PROTEIN (Bacillus halodurans)	4 / 7	ALA A 142 TYR A 107 ILE A 106 ILE A 104	None	0.68A	1upfB-3o5yA: undetectable	1upfB-3o5yA: 23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3W1W_A_CHDA1503_0 (FERROCHELATASE, MITOCHONDRIAL)	3o5y	SENSOR PROTEIN (Bacillus halodurans)	4 / 8	ILE A 14 LEU A 10 VAL A 113 GLY A 114	None	0.74A	3w1wA-3o5yA: undetectable	3w1wA-3o5yA: 19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L1X_A_STRA402_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2)	3o5y	SENSOR PROTEIN (Bacillus halodurans)	4 / 8	LEU A 65 TYR A 66 LEU A 98 LEU A 80	None ACT A 2 (-4.6A) None None	0.83A	4l1xA-3o5yA: undetectable	4l1xA-3o5yA: 21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Y0R_A_PX9A201_0 (BETA-LACTOGLOBULIN)	3o5y	SENSOR PROTEIN (Bacillus halodurans)	5 / 12	LEU A 102 ILE A 118 LEU A 116 ILE A 30 VAL A 25	None	0.81A	4y0rA-3o5yA: undetectable	4y0rA-3o5yA: 19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZZB_A_ACTA404_0 (PROTON-GATED ION CHANNEL)	3o5y	SENSOR PROTEIN (Bacillus halodurans)	4 / 4	LEU A 33 ILE A 59 ARG A 29 TYR A 66	None None ACT A 2 (-2.8A) ACT A 2 (-4.6A)	1.16A	4zzbA-3o5yA: undetectable	4zzbA-3o5yA: 19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZZC_B_ACTB406_0 (PROTON-GATED ION CHANNEL)	3o5y	SENSOR PROTEIN (Bacillus halodurans)	4 / 4	LEU A 33 ILE A 59 ARG A 29 TYR A 66	None None ACT A 2 (-2.8A) ACT A 2 (-4.6A)	1.28A	4zzcB-3o5yA: undetectable	4zzcB-3o5yA: 19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TE8_A_08JA602_1 (CYTOCHROME P450 3A4)	3o5y	SENSOR PROTEIN (Bacillus halodurans)	4 / 7	LEU A 102 THR A 138 ILE A 106 LEU A 116	None	1.01A	5te8A-3o5yA: undetectable	5te8A-3o5yA: 15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6IE8_A_CHDA201_0 (REGULATORY PROTEIN)	3o5y	SENSOR PROTEIN (Bacillus halodurans)	5 / 12	LEU A 33 THR A 75 TYR A 66 LEU A 102 LEU A 93	None None ACT A 2 (-4.6A) None None	1.31A	6ie8A-3o5yA: undetectable	6ie8A-3o5yA: 19.31

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1UPF_B_URFB999_1","URACIL PHOSPHORIBOSYLTRANSFERASE","3o5y","SENSOR PROTEIN","Bacillus halodurans",4,"ALA A 142;TYR A 107;ILE A 106;ILE A 104","None","0.68A","1upfB-3o5yA:undetectable","1upfB-3o5yA:23.66"],["3W1W_A_CHDA1503_0","FERROCHELATASE, MITOCHONDRIAL","3o5y","SENSOR PROTEIN","Bacillus halodurans",4,"ILE A  14;LEU A  10;VAL A 113;GLY A 114","None","0.74A","3w1wA-3o5yA:undetectable","3w1wA-3o5yA:19.50"],["4L1X_A_STRA402_1","ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2","3o5y","SENSOR PROTEIN","Bacillus halodurans",4,"LEU A  65;TYR A  66;LEU A  98;LEU A  80","None;ACT A   2 (-4.6A);None;None","0.83A","4l1xA-3o5yA:undetectable","4l1xA-3o5yA:21.33"],["4Y0R_A_PX9A201_0","BETA-LACTOGLOBULIN","3o5y","SENSOR PROTEIN","Bacillus halodurans",5,"LEU A 102;ILE A 118;LEU A 116;ILE A  30;VAL A  25","None","0.81A","4y0rA-3o5yA:undetectable","4y0rA-3o5yA:19.67"],["4ZZB_A_ACTA404_0","PROTON-GATED ION CHANNEL","3o5y","SENSOR PROTEIN","Bacillus halodurans",4,"LEU A  33;ILE A  59;ARG A  29;TYR A  66","None;None;ACT A   2 (-2.8A);ACT A   2 (-4.6A)","1.16A","4zzbA-3o5yA:undetectable","4zzbA-3o5yA:19.09"],["4ZZC_B_ACTB406_0","PROTON-GATED ION CHANNEL","3o5y","SENSOR PROTEIN","Bacillus halodurans",4,"LEU A  33;ILE A  59;ARG A  29;TYR A  66","None;None;ACT A   2 (-2.8A);ACT A   2 (-4.6A)","1.28A","4zzcB-3o5yA:undetectable","4zzcB-3o5yA:19.54"],["5TE8_A_08JA602_1","CYTOCHROME P450 3A4","3o5y","SENSOR PROTEIN","Bacillus halodurans",4,"LEU A 102;THR A 138;ILE A 106;LEU A 116","None","1.01A","5te8A-3o5yA:undetectable","5te8A-3o5yA:15.72"],["6IE8_A_CHDA201_0","REGULATORY PROTEIN","3o5y","SENSOR PROTEIN","Bacillus halodurans",5,"LEU A  33;THR A  75;TYR A  66;LEU A 102;LEU A  93","None;None;ACT A   2 (-4.6A);None;None","1.31A","6ie8A-3o5yA:undetectable","6ie8A-3o5yA:19.31"]]