SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o63'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 3o63 PROBABLE
THIAMINE-PHOSPHATE
PYROPHOSPHORYLASE
(Mycobacterium
tuberculosis) 		5 / 11 THR A  15
ILE A  39
ILE A  66
ALA A  25
ALA A  28
 None
 1.04A 2qhfA-3o63A:
undetectable		 2qhfA-3o63A:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 3o63 PROBABLE
THIAMINE-PHOSPHATE
PYROPHOSPHORYLASE
(Mycobacterium
tuberculosis) 		5 / 12 HIS A 122
SER A 120
THR A 121
GLY A 177
GLY A 141
 PO4  A 223 (-4.3A)
PO4  A 223 ( 4.2A)
None
None
None
 1.08A 3fzgA-3o63A:
undetectable		 3fzgA-3o63A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 3o63 PROBABLE
THIAMINE-PHOSPHATE
PYROPHOSPHORYLASE
(Mycobacterium
tuberculosis) 		4 / 6 LEU A  95
ALA A 135
ARG A 119
LEU A 111
 None
 1.16A 3rd0A-3o63A:
undetectable		 3rd0A-3o63A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 3o63 PROBABLE
THIAMINE-PHOSPHATE
PYROPHOSPHORYLASE
(Mycobacterium
tuberculosis) 		4 / 7 ALA A 204
PRO A 207
ARG A 208
ALA A 211
 None
 1.09A 3twpB-3o63A:
undetectable		 3twpB-3o63A:
26.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMU_C_RFPC1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3o63 PROBABLE
THIAMINE-PHOSPHATE
PYROPHOSPHORYLASE
(Mycobacterium
tuberculosis) 		5 / 12 ASP A  16
LEU A 214
PRO A 207
ILE A 201
ARG A  18
 None
 1.43A 4kmuC-3o63A:
undetectable		 4kmuC-3o63A:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMU_H_RFPH1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3o63 PROBABLE
THIAMINE-PHOSPHATE
PYROPHOSPHORYLASE
(Mycobacterium
tuberculosis) 		5 / 12 ASP A  16
LEU A 214
PRO A 207
ILE A 201
ARG A  18
 None
 1.39A 4kmuH-3o63A:
undetectable		 4kmuH-3o63A:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)		 3o63 PROBABLE
THIAMINE-PHOSPHATE
PYROPHOSPHORYLASE
(Mycobacterium
tuberculosis) 		3 / 3 GLY A  53
PRO A  54
GLN A  56
 None
 0.54A 4oltB-3o63A:
undetectable		 4oltB-3o63A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_2
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 3o63 PROBABLE
THIAMINE-PHOSPHATE
PYROPHOSPHORYLASE
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 111
CYH A  64
LEU A  61
ASP A  85
 None
 1.50A 5mafA-3o63A:
undetectable		 5mafA-3o63A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 3o63 PROBABLE
THIAMINE-PHOSPHATE
PYROPHOSPHORYLASE
(Mycobacterium
tuberculosis) 		4 / 6 GLY A 118
GLN A  40
TYR A  12
TYR A 137
 None
 1.23A 6ag0A-3o63A:
8.8		 6ag0A-3o63A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 3o63 PROBABLE
THIAMINE-PHOSPHATE
PYROPHOSPHORYLASE
(Mycobacterium
tuberculosis) 		4 / 6 GLY A 118
GLN A  40
TYR A  12
TYR A 137
 None
 1.22A 6ag0C-3o63A:
8.4		 6ag0C-3o63A:
18.57