SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o66'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 3o66 GLYCINE
BETAINE/CARNITINE/CH
OLINE ABC
TRANSPORTER
(Staphylococcus
aureus) 		3 / 3 ASN A 281
TYR A  94
SER A 221
 ACT  A 323 (-3.8A)
PGE  A 321 (-3.8A)
None
 0.91A 2gvcB-3o66A:
undetectable		 2gvcB-3o66A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 3o66 GLYCINE
BETAINE/CARNITINE/CH
OLINE ABC
TRANSPORTER
(Staphylococcus
aureus) 		3 / 3 ASN A 281
TYR A  94
SER A 221
 ACT  A 323 (-3.8A)
PGE  A 321 (-3.8A)
None
 0.93A 2gvcE-3o66A:
undetectable		 2gvcE-3o66A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3o66 GLYCINE
BETAINE/CARNITINE/CH
OLINE ABC
TRANSPORTER
(Staphylococcus
aureus) 		4 / 8 LEU A 167
PHE A 194
THR A 156
LEU A 154
 None
 0.79A 3ag3N-3o66A:
undetectable
3ag3W-3o66A:
undetectable		 3ag3N-3o66A:
19.92
3ag3W-3o66A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 3o66 GLYCINE
BETAINE/CARNITINE/CH
OLINE ABC
TRANSPORTER
(Staphylococcus
aureus) 		4 / 8 LYS A 109
TYR A 220
ASP A 236
GLN A 239
 None
PGE  A 321 ( 3.4A)
None
None
 1.27A 3dh0A-3o66A:
undetectable		 3dh0A-3o66A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3o66 GLYCINE
BETAINE/CARNITINE/CH
OLINE ABC
TRANSPORTER
(Staphylococcus
aureus) 		4 / 5 ILE A 226
THR A 139
PHE A 241
PHE A 142
 None
 1.14A 3em0A-3o66A:
undetectable		 3em0A-3o66A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3o66 GLYCINE
BETAINE/CARNITINE/CH
OLINE ABC
TRANSPORTER
(Staphylococcus
aureus) 		4 / 8 GLY A 219
ASP A 223
ILE A 226
VAL A 233
 None
ACT  A 323 (-4.3A)
None
None
 0.80A 3fi0B-3o66A:
undetectable		 3fi0B-3o66A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3o66 GLYCINE
BETAINE/CARNITINE/CH
OLINE ABC
TRANSPORTER
(Staphylococcus
aureus) 		4 / 7 GLY A 219
ASP A 223
ILE A 226
VAL A 233
 None
ACT  A 323 (-4.3A)
None
None
 0.81A 3fi0E-3o66A:
undetectable		 3fi0E-3o66A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3o66 GLYCINE
BETAINE/CARNITINE/CH
OLINE ABC
TRANSPORTER
(Staphylococcus
aureus) 		4 / 8 GLY A 219
ASP A 223
ILE A 226
VAL A 233
 None
ACT  A 323 (-4.3A)
None
None
 0.76A 3fi0Q-3o66A:
undetectable		 3fi0Q-3o66A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 3o66 GLYCINE
BETAINE/CARNITINE/CH
OLINE ABC
TRANSPORTER
(Staphylococcus
aureus) 		3 / 3 ASP A 236
PHE A 142
SER A 221
 None
 1.00A 3i5uB-3o66A:
undetectable		 3i5uB-3o66A:
21.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PPO_A_DCKA401_0
(GLYCINE
BETAINE/CARNITINE/CH
OLINE-BINDING
PROTEIN)		 3o66 GLYCINE
BETAINE/CARNITINE/CH
OLINE ABC
TRANSPORTER
(Staphylococcus
aureus) 		5 / 9 SER A  74
TYR A  94
THR A  97
ASN A 138
TYR A 244
 None
PGE  A 321 (-3.8A)
PGE  A 321 ( 4.9A)
ACT  A 323 ( 2.9A)
PGE  A 321 (-3.8A)
 0.31A 3ppoA-3o66A:
36.5		 3ppoA-3o66A:
57.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PPO_A_DCKA401_0
(GLYCINE
BETAINE/CARNITINE/CH
OLINE-BINDING
PROTEIN)		 3o66 GLYCINE
BETAINE/CARNITINE/CH
OLINE ABC
TRANSPORTER
(Staphylococcus
aureus) 		5 / 9 TYR A  94
THR A  97
ASN A 138
TYR A 220
TYR A 244
 PGE  A 321 (-3.8A)
PGE  A 321 ( 4.9A)
ACT  A 323 ( 2.9A)
PGE  A 321 ( 3.4A)
PGE  A 321 (-3.8A)
 0.72A 3ppoA-3o66A:
36.5		 3ppoA-3o66A:
57.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PPO_B_DCKB401_0
(GLYCINE
BETAINE/CARNITINE/CH
OLINE-BINDING
PROTEIN)		 3o66 GLYCINE
BETAINE/CARNITINE/CH
OLINE ABC
TRANSPORTER
(Staphylococcus
aureus) 		5 / 9 SER A  74
TYR A  94
THR A  97
ASN A 138
TYR A 244
 None
PGE  A 321 (-3.8A)
PGE  A 321 ( 4.9A)
ACT  A 323 ( 2.9A)
PGE  A 321 (-3.8A)
 0.27A 3ppoB-3o66A:
36.7		 3ppoB-3o66A:
57.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PPO_B_DCKB401_0
(GLYCINE
BETAINE/CARNITINE/CH
OLINE-BINDING
PROTEIN)		 3o66 GLYCINE
BETAINE/CARNITINE/CH
OLINE ABC
TRANSPORTER
(Staphylococcus
aureus) 		5 / 9 TYR A  94
THR A  97
ASN A 138
TYR A 220
TYR A 244
 PGE  A 321 (-3.8A)
PGE  A 321 ( 4.9A)
ACT  A 323 ( 2.9A)
PGE  A 321 ( 3.4A)
PGE  A 321 (-3.8A)
 0.67A 3ppoB-3o66A:
36.7		 3ppoB-3o66A:
57.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RZE_A_D7VA1201_1
(HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA)		 3o66 GLYCINE
BETAINE/CARNITINE/CH
OLINE ABC
TRANSPORTER
(Staphylococcus
aureus) 		5 / 12 ASP A  98
SER A  75
THR A  76
ILE A  77
ASN A  80
 None
 1.12A 3rzeA-3o66A:
undetectable		 3rzeA-3o66A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 3o66 GLYCINE
BETAINE/CARNITINE/CH
OLINE ABC
TRANSPORTER
(Staphylococcus
aureus) 		4 / 8 ARG A  53
GLU A  57
GLU A 296
LYS A 300
 None
 1.06A 4bqfB-3o66A:
undetectable		 4bqfB-3o66A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 3o66 GLYCINE
BETAINE/CARNITINE/CH
OLINE ABC
TRANSPORTER
(Staphylococcus
aureus) 		4 / 8 ASP A 237
ASP A 236
PHE A 192
LEU A 160
 None
 1.11A 4f8hB-3o66A:
undetectable
4f8hC-3o66A:
undetectable		 4f8hB-3o66A:
20.67
4f8hC-3o66A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 3o66 GLYCINE
BETAINE/CARNITINE/CH
OLINE ABC
TRANSPORTER
(Staphylococcus
aureus) 		5 / 12 TYR A 183
VAL A 216
ALA A 217
PHE A 192
PHE A 194
 None
 1.08A 4mm6A-3o66A:
undetectable		 4mm6A-3o66A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 3o66 GLYCINE
BETAINE/CARNITINE/CH
OLINE ABC
TRANSPORTER
(Staphylococcus
aureus) 		5 / 12 TYR A 183
VAL A 216
PHE A 192
PHE A 194
VAL A 197
 None
 1.28A 4mm6A-3o66A:
undetectable		 4mm6A-3o66A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 3o66 GLYCINE
BETAINE/CARNITINE/CH
OLINE ABC
TRANSPORTER
(Staphylococcus
aureus) 		5 / 12 VAL A  69
LEU A  40
SER A  45
LEU A 254
ILE A 265
 None
 1.17A 5hv1A-3o66A:
undetectable		 5hv1A-3o66A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3o66 GLYCINE
BETAINE/CARNITINE/CH
OLINE ABC
TRANSPORTER
(Staphylococcus
aureus) 		4 / 8 LEU A 167
PHE A 194
THR A 156
LEU A 154
 None
 0.83A 5zcoA-3o66A:
undetectable
5zcoJ-3o66A:
undetectable		 5zcoA-3o66A:
19.92
5zcoJ-3o66A:
11.55