SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o6b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3o6b DEFECTIVE IN CULLIN
NEDDYLATION PROTEIN
1
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 116
GLN A 137
THR A 133
THR A 109
 None
 1.26A 2zj0B-3o6bA:
undetectable		 2zj0B-3o6bA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3o6b DEFECTIVE IN CULLIN
NEDDYLATION PROTEIN
1
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 116
GLN A 137
THR A 133
THR A 109
 None
 1.32A 2zj0C-3o6bA:
undetectable		 2zj0C-3o6bA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3o6b DEFECTIVE IN CULLIN
NEDDYLATION PROTEIN
1
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 116
GLN A 137
THR A 133
THR A 109
 None
 1.25A 2zj0D-3o6bA:
undetectable		 2zj0D-3o6bA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3o6b DEFECTIVE IN CULLIN
NEDDYLATION PROTEIN
1
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 116
GLN A 137
THR A 133
THR A 109
 None
 1.30A 3ce6B-3o6bA:
undetectable		 3ce6B-3o6bA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 3o6b DEFECTIVE IN CULLIN
NEDDYLATION PROTEIN
1
CELL DIVISION
CONTROL PROTEIN 53
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 ASP B 794
TRP A 211
SER A 224
 None
 1.06A 4lrhF-3o6bB:
undetectable		 4lrhF-3o6bB:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 3o6b CELL DIVISION
CONTROL PROTEIN 53
(Saccharomyces
cerevisiae) 		4 / 6 CYH B 774
CYH B 754
LEU B 751
HIS B 779
 None
 1.19A 5hpuC-3o6bB:
undetectable
5hpuD-3o6bB:
undetectable		 5hpuC-3o6bB:
16.22
5hpuD-3o6bB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3o6b CELL DIVISION
CONTROL PROTEIN 53
DEFECTIVE IN CULLIN
NEDDYLATION PROTEIN
1
(Saccharomyces
cerevisiae) 		5 / 12 ILE B 793
TYR B 811
HIS B 767
GLU A 250
ILE A 257
 None
 1.06A 5igvA-3o6bB:
undetectable		 5igvA-3o6bB:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3o6b DEFECTIVE IN CULLIN
NEDDYLATION PROTEIN
1
CELL DIVISION
CONTROL PROTEIN 53
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 ILE B 793
TYR B 811
HIS B 767
GLU A 250
ILE A 257
 None
 0.98A 5iwuA-3o6bB:
undetectable		 5iwuA-3o6bB:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 3o6b CELL DIVISION
CONTROL PROTEIN 53
DEFECTIVE IN CULLIN
NEDDYLATION PROTEIN
1
(Saccharomyces
cerevisiae) 		5 / 12 MET B 759
ILE B 755
ALA A 253
VAL B 771
ILE B 793
 None
 1.28A 5mlmA-3o6bB:
undetectable		 5mlmA-3o6bB:
11.66