SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o6n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 3o6n APL1
(Anopheles
gambiae) 		4 / 6 LEU A 321
ILE A 350
TYR A 380
VAL A 313
 None
 0.98A 1db1A-3o6nA:
undetectable		 1db1A-3o6nA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_2
(HMG-COA REDUCTASE)		 3o6n APL1
(Anopheles
gambiae) 		5 / 11 ARG A 354
ASN A 369
LEU A 334
ALA A 335
LEU A 315
 None
 1.38A 1hwkB-3o6nA:
undetectable		 1hwkB-3o6nA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_B_117B1_1
(HMG-COA REDUCTASE)		 3o6n APL1
(Anopheles
gambiae) 		5 / 11 ARG A 354
ASN A 369
LEU A 334
ALA A 335
LEU A 315
 None
 1.34A 1hwkA-3o6nA:
undetectable		 1hwkA-3o6nA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_2
(HMG-COA REDUCTASE)		 3o6n APL1
(Anopheles
gambiae) 		5 / 11 ARG A 354
ASN A 369
LEU A 334
ALA A 335
LEU A 315
 None
 1.37A 1hwkD-3o6nA:
undetectable		 1hwkD-3o6nA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_1
(HMG-COA REDUCTASE)		 3o6n APL1
(Anopheles
gambiae) 		5 / 11 ARG A 354
ASN A 369
LEU A 334
ALA A 335
LEU A 315
 None
 1.39A 1hwkC-3o6nA:
undetectable		 1hwkC-3o6nA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 3o6n APL1
(Anopheles
gambiae) 		4 / 6 LEU A 334
TRP A 376
ASN A 369
LEU A 371
 None
 1.41A 1ru9H-3o6nA:
undetectable
1ru9L-3o6nA:
undetectable		 1ru9H-3o6nA:
19.39
1ru9L-3o6nA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 3o6n APL1
(Anopheles
gambiae) 		4 / 5 LEU A 334
TRP A 376
ASN A 369
LEU A 371
 None
 1.49A 1ruaH-3o6nA:
0.0
1ruaL-3o6nA:
0.0		 1ruaH-3o6nA:
19.39
1ruaL-3o6nA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 3o6n APL1
(Anopheles
gambiae) 		4 / 6 LEU A 334
TRP A 376
ASN A 369
LEU A 371
 None
 1.42A 1rukH-3o6nA:
undetectable
1rukL-3o6nA:
undetectable		 1rukH-3o6nA:
19.39
1rukL-3o6nA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUL_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 3o6n APL1
(Anopheles
gambiae) 		4 / 5 LEU A 334
TRP A 376
ASN A 369
LEU A 371
 None
 1.46A 1rulH-3o6nA:
0.0
1rulL-3o6nA:
0.0		 1rulH-3o6nA:
19.39
1rulL-3o6nA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)		 3o6n APL1
(Anopheles
gambiae) 		4 / 7 ASP A 503
TYR A 457
ASP A 502
HIS A 481
 None
NAG  A1004 (-3.9A)
NAG  A1004 (-3.8A)
None
 1.46A 1t03A-3o6nA:
undetectable		 1t03A-3o6nA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 3o6n APL1
(Anopheles
gambiae) 		4 / 8 ILE A 412
SER A 389
ASP A 387
LEU A 410
 None
 1.01A 2cdqA-3o6nA:
undetectable		 2cdqA-3o6nA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 3o6n APL1
(Anopheles
gambiae) 		5 / 12 MET A 281
LEU A 265
LEU A 241
LEU A 252
VAL A 249
 None
 1.22A 2hrcB-3o6nA:
undetectable		 2hrcB-3o6nA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3o6n APL1
(Anopheles
gambiae) 		5 / 12 ALA A 345
LEU A 371
VAL A 353
LEU A 377
PRO A 400
 None
 1.19A 2qk8A-3o6nA:
undetectable		 2qk8A-3o6nA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3o6n APL1
(Anopheles
gambiae) 		4 / 8 THR A 478
ASP A 459
SER A 436
TYR A 411
 NAG  A1004 ( 4.5A)
None
None
None
 1.23A 2xz5A-3o6nA:
undetectable
2xz5C-3o6nA:
undetectable		 2xz5A-3o6nA:
21.19
2xz5C-3o6nA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3o6n APL1
(Anopheles
gambiae) 		4 / 8 THR A 478
ASP A 459
SER A 436
TYR A 411
 NAG  A1004 ( 4.5A)
None
None
None
 1.21A 2xz5C-3o6nA:
undetectable
2xz5D-3o6nA:
undetectable		 2xz5C-3o6nA:
21.19
2xz5D-3o6nA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3o6n APL1
(Anopheles
gambiae) 		4 / 8 ASN A 391
ASN A 369
ILE A 336
VAL A 386
 None
 0.90A 2yoeB-3o6nA:
undetectable
2yoeC-3o6nA:
undetectable		 2yoeB-3o6nA:
22.63
2yoeC-3o6nA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 3o6n APL1
(Anopheles
gambiae) 		5 / 12 MET A 190
ILE A 214
LEU A 212
ALA A 221
LEU A 231
 None
 0.93A 3a50D-3o6nA:
undetectable		 3a50D-3o6nA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3o6n APL1
(Anopheles
gambiae) 		4 / 7 ARG A 498
SER A 480
LEU A 468
ILE A 463
 None
 0.82A 3ln1C-3o6nA:
undetectable		 3ln1C-3o6nA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3o6n APL1
(Anopheles
gambiae) 		3 / 3 TYR A 220
ASP A 199
ASP A 167
 None
 0.80A 3ou7B-3o6nA:
undetectable		 3ou7B-3o6nA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_D_T44D328_1
(5-HYDROXYISOURATE
HYDROLASE)		 3o6n APL1
(Anopheles
gambiae) 		5 / 9 LEU A 422
PRO A 400
THR A 374
LEU A 388
LEU A 393
 None
 1.35A 3q1eB-3o6nA:
undetectable
3q1eD-3o6nA:
undetectable		 3q1eB-3o6nA:
14.07
3q1eD-3o6nA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 3o6n APL1
(Anopheles
gambiae) 		5 / 12 PHE A 450
ILE A 463
LEU A 440
LEU A 410
LEU A 433
 None
 1.39A 4qynB-3o6nA:
undetectable		 4qynB-3o6nA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 3o6n APL1
(Anopheles
gambiae) 		5 / 9 VAL A 168
LEU A 209
SER A 188
THR A 189
LEU A 212
 None
 1.30A 4ubsA-3o6nA:
undetectable		 4ubsA-3o6nA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 3o6n APL1
(Anopheles
gambiae) 		4 / 7 LEU A 315
ALA A 345
ASN A 348
ILE A 350
 None
 0.84A 4y03A-3o6nA:
undetectable		 4y03A-3o6nA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 3o6n APL1
(Anopheles
gambiae) 		5 / 10 SER A 389
GLN A 449
LEU A 422
SER A 413
LEU A 453
 None
 1.10A 4yiaA-3o6nA:
undetectable		 4yiaA-3o6nA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N1T_W_CUW201_0
(COPC)		 3o6n APL1
(Anopheles
gambiae) 		3 / 3 HIS A 437
ASP A 459
HIS A 460
 None
 0.94A 5n1tW-3o6nA:
undetectable		 5n1tW-3o6nA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SVL_A_ACTA411_0
(P2X PURINOCEPTOR 3)		 3o6n APL1
(Anopheles
gambiae) 		4 / 5 GLN A 367
VAL A 326
ASP A 344
ASN A 348
 None
None
NAG  A1001 (-3.6A)
None
 1.45A 5svlA-3o6nA:
0.0		 5svlA-3o6nA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 3o6n APL1
(Anopheles
gambiae) 		5 / 12 ILE A 217
LEU A 197
LEU A 241
PHE A 222
LEU A 262
 None
 1.23A 6b54A-3o6nA:
undetectable		 6b54A-3o6nA:
20.05