SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o6o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 3o6o HEAT SHOCK PROTEIN
83
(Trypanosoma
brucei) 		5 / 12 ASN A  36
SER A  37
ASP A  39
ASP A  78
THR A 169
 94M  A 214 (-4.1A)
94M  A 214 (-3.6A)
None
94M  A 214 (-3.4A)
94M  A 214 (-3.8A)
 0.31A 1s14A-3o6oA:
10.0		 1s14A-3o6oA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 3o6o HEAT SHOCK PROTEIN
83
(Trypanosoma
brucei) 		5 / 12 SER A  37
ASP A  39
ASP A  78
MET A  83
THR A 169
 94M  A 214 (-3.6A)
None
94M  A 214 (-3.4A)
94M  A 214 (-3.4A)
94M  A 214 (-3.8A)
 0.68A 1s14A-3o6oA:
10.0		 1s14A-3o6oA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 3o6o HEAT SHOCK PROTEIN
83
(Trypanosoma
brucei) 		4 / 7 LEU A 173
ILE A 171
ASN A  36
PHE A 123
 None
None
94M  A 214 (-4.1A)
94M  A 214 (-3.7A)
 0.87A 2opxA-3o6oA:
undetectable		 2opxA-3o6oA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 3o6o HEAT SHOCK PROTEIN
83
(Trypanosoma
brucei) 		5 / 12 LEU A  33
LEU A  88
ILE A 171
PHE A 123
PHE A   7
 None
94M  A 214 (-4.5A)
None
94M  A 214 (-3.7A)
None
 0.79A 2ygqA-3o6oA:
undetectable		 2ygqA-3o6oA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 3o6o HEAT SHOCK PROTEIN
83
(Trypanosoma
brucei) 		5 / 12 ASN A  36
SER A  37
ASP A  39
ASP A  78
THR A 169
 94M  A 214 (-4.1A)
94M  A 214 (-3.6A)
None
94M  A 214 (-3.4A)
94M  A 214 (-3.8A)
 0.29A 3lpsA-3o6oA:
11.4		 3lpsA-3o6oA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 3o6o HEAT SHOCK PROTEIN
83
(Trypanosoma
brucei) 		5 / 12 SER A  37
ASP A  39
ASP A  78
MET A  83
THR A 169
 94M  A 214 (-3.6A)
None
94M  A 214 (-3.4A)
94M  A 214 (-3.4A)
94M  A 214 (-3.8A)
 0.61A 3lpsA-3o6oA:
11.4		 3lpsA-3o6oA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3o6o HEAT SHOCK PROTEIN
83
(Trypanosoma
brucei) 		5 / 11 ASN A  36
SER A  37
ASP A  39
ASP A  78
THR A 169
 94M  A 214 (-4.1A)
94M  A 214 (-3.6A)
None
94M  A 214 (-3.4A)
94M  A 214 (-3.8A)
 0.37A 4urnA-3o6oA:
11.4		 4urnA-3o6oA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3o6o HEAT SHOCK PROTEIN
83
(Trypanosoma
brucei) 		5 / 11 SER A  37
ASP A  39
ASP A  78
MET A  83
THR A 169
 94M  A 214 (-3.6A)
None
94M  A 214 (-3.4A)
94M  A 214 (-3.4A)
94M  A 214 (-3.8A)
 0.67A 4urnA-3o6oA:
11.4		 4urnA-3o6oA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3o6o HEAT SHOCK PROTEIN
83
(Trypanosoma
brucei) 		5 / 11 ASN A  36
SER A  37
ASP A  39
ASP A  78
THR A 169
 94M  A 214 (-4.1A)
94M  A 214 (-3.6A)
None
94M  A 214 (-3.4A)
94M  A 214 (-3.8A)
 0.38A 4urnB-3o6oA:
11.0		 4urnB-3o6oA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3o6o HEAT SHOCK PROTEIN
83
(Trypanosoma
brucei) 		5 / 11 SER A  37
ASP A  39
ASP A  78
MET A  83
THR A 169
 94M  A 214 (-3.6A)
None
94M  A 214 (-3.4A)
94M  A 214 (-3.4A)
94M  A 214 (-3.8A)
 0.67A 4urnB-3o6oA:
11.0		 4urnB-3o6oA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3o6o HEAT SHOCK PROTEIN
83
(Trypanosoma
brucei) 		5 / 11 ASN A  36
SER A  37
ASP A  39
ASP A  78
THR A 169
 94M  A 214 (-4.1A)
94M  A 214 (-3.6A)
None
94M  A 214 (-3.4A)
94M  A 214 (-3.8A)
 0.34A 4urnC-3o6oA:
11.2		 4urnC-3o6oA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3o6o HEAT SHOCK PROTEIN
83
(Trypanosoma
brucei) 		5 / 11 SER A  37
ASP A  39
ASP A  78
MET A  83
THR A 169
 94M  A 214 (-3.6A)
None
94M  A 214 (-3.4A)
94M  A 214 (-3.4A)
94M  A 214 (-3.8A)
 0.62A 4urnC-3o6oA:
11.2		 4urnC-3o6oA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3o6o HEAT SHOCK PROTEIN
83
(Trypanosoma
brucei) 		4 / 7 ILE A 192
ARG A  64
THR A  75
LEU A  74
 None
 0.96A 5b1aA-3o6oA:
undetectable
5b1aJ-3o6oA:
undetectable		 5b1aA-3o6oA:
17.96
5b1aJ-3o6oA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3o6o HEAT SHOCK PROTEIN
83
(Trypanosoma
brucei) 		4 / 7 ILE A 192
ARG A  64
THR A  75
LEU A  74
 None
 0.93A 5b3sA-3o6oA:
undetectable
5b3sJ-3o6oA:
undetectable		 5b3sA-3o6oA:
17.96
5b3sJ-3o6oA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 3o6o HEAT SHOCK PROTEIN
83
(Trypanosoma
brucei) 		5 / 10 MET A  15
ILE A  11
PHE A   7
SER A 149
GLU A 148
 None
 1.34A 5tixB-3o6oA:
undetectable		 5tixB-3o6oA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3o6o HEAT SHOCK PROTEIN
83
(Trypanosoma
brucei) 		4 / 8 ILE A 192
ARG A  64
THR A  75
LEU A  74
 None
 0.93A 5zcoA-3o6oA:
undetectable
5zcoJ-3o6oA:
undetectable		 5zcoA-3o6oA:
17.96
5zcoJ-3o6oA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3o6o HEAT SHOCK PROTEIN
83
(Trypanosoma
brucei) 		4 / 7 ILE A 192
ARG A  64
THR A  75
LEU A  74
 None
 0.92A 5zcpA-3o6oA:
undetectable
5zcpJ-3o6oA:
undetectable		 5zcpA-3o6oA:
17.96
5zcpJ-3o6oA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3o6o HEAT SHOCK PROTEIN
83
(Trypanosoma
brucei) 		4 / 7 ILE A 192
ARG A  64
THR A  75
LEU A  74
 None
 0.98A 5zcqA-3o6oA:
undetectable
5zcqJ-3o6oA:
undetectable		 5zcqA-3o6oA:
17.96
5zcqJ-3o6oA:
13.08