SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o6p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_C_ADNC502_1
(HYPOTHETICAL PROTEIN
PH0463)		 3o6p PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN
(Enterococcus
faecalis) 		4 / 7 PHE A 468
ASN A 475
ASN A 481
VAL A 488
 None
 1.32A 1wu8A-3o6pA:
undetectable
1wu8C-3o6pA:
undetectable		 1wu8A-3o6pA:
24.16
1wu8C-3o6pA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 3o6p PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN
(Enterococcus
faecalis) 		3 / 3 SER A 492
ASP A 466
ASN A 472
 None
 0.83A 3lsfB-3o6pA:
undetectable
3lsfE-3o6pA:
1.4		 3lsfB-3o6pA:
21.37
3lsfE-3o6pA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		 3o6p PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN
(Enterococcus
faecalis) 		3 / 3 ASP A 466
ASN A 472
SER A 492
 None
 0.84A 3lsfB-3o6pA:
undetectable
3lsfE-3o6pA:
1.4		 3lsfB-3o6pA:
21.37
3lsfE-3o6pA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3o6p PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN
(Enterococcus
faecalis) 		4 / 7 VAL A 412
VAL A 520
ILE A 419
ARG A 441
 None
 1.06A 3mssB-3o6pA:
undetectable		 3mssB-3o6pA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3o6p PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN
(Enterococcus
faecalis) 		4 / 6 VAL A 426
LEU A 423
LEU A 322
PHE A 447
 NA  A 601 (-4.6A)
None
None
None
 1.13A 4o1zA-3o6pA:
undetectable		 4o1zA-3o6pA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 3o6p PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN
(Enterococcus
faecalis) 		3 / 4 ARG A 476
GLY A 477
GLU A 307
 None
 0.47A 4z2dB-3o6pA:
undetectable
4z2dC-3o6pA:
undetectable		 4z2dB-3o6pA:
19.11
4z2dC-3o6pA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 3o6p PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN
(Enterococcus
faecalis) 		5 / 10 LEU A 308
ALA A 449
GLU A 374
SER A 329
VAL A 428
 None
 1.27A 6b89A-3o6pA:
undetectable		 6b89A-3o6pA:
18.98