SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o6x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 3o6x GLUTAMINE SYNTHETASE
(Bacteroides
fragilis) 		4 / 8 ASN A 481
LEU A 183
ALA A 186
LEU A 187
 None
 0.97A 1hwiB-3o6xA:
2.4		 1hwiB-3o6xA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 3o6x GLUTAMINE SYNTHETASE
(Bacteroides
fragilis) 		4 / 8 ASN A 481
LEU A 183
ALA A 186
LEU A 187
 None
 0.97A 1hwiC-3o6xA:
undetectable		 1hwiC-3o6xA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 3o6x GLUTAMINE SYNTHETASE
(Bacteroides
fragilis) 		5 / 12 ILE A 705
ASP A 231
ILE A 615
ALA A 619
ARG A 702
 None
 1.25A 1kijB-3o6xA:
undetectable		 1kijB-3o6xA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 3o6x GLUTAMINE SYNTHETASE
(Bacteroides
fragilis) 		5 / 12 THR A  61
GLY A 152
ASP A 151
ILE A 168
ALA A 176
 None
 1.30A 1oltA-3o6xA:
undetectable		 1oltA-3o6xA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3o6x GLUTAMINE SYNTHETASE
(Bacteroides
fragilis) 		4 / 4 ALA A 319
VAL A 326
ALA A 325
HIS A 323
 None
 1.10A 1q23A-3o6xA:
undetectable		 1q23A-3o6xA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 3o6x GLUTAMINE SYNTHETASE
(Bacteroides
fragilis) 		4 / 6 ALA A 548
LEU A 552
ILE A 408
CYH A 556
 None
 0.99A 1sbrA-3o6xA:
2.9
1sbrB-3o6xA:
0.9		 1sbrA-3o6xA:
13.36
1sbrB-3o6xA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3o6x GLUTAMINE SYNTHETASE
(Bacteroides
fragilis) 		3 / 3 HIS A  89
ASP A 178
ASN A 481
 None
 0.87A 1wg8B-3o6xA:
undetectable		 1wg8B-3o6xA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_C_ADNC502_1
(HYPOTHETICAL PROTEIN
PH0463)		 3o6x GLUTAMINE SYNTHETASE
(Bacteroides
fragilis) 		4 / 7 PHE A 356
ASN A 354
ASN A 211
VAL A 208
 None
ADP  A4001 ( 4.4A)
None
None
 1.42A 1wu8A-3o6xA:
undetectable
1wu8C-3o6xA:
0.2		 1wu8A-3o6xA:
16.90
1wu8C-3o6xA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3o6x GLUTAMINE SYNTHETASE
(Bacteroides
fragilis) 		4 / 7 LEU A 355
PHE A 356
MET A 493
LEU A 497
 None
 1.08A 2eikA-3o6xA:
1.3
2eikJ-3o6xA:
undetectable		 2eikA-3o6xA:
21.45
2eikJ-3o6xA:
6.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3o6x GLUTAMINE SYNTHETASE
(Bacteroides
fragilis) 		4 / 6 PRO A 166
ILE A 168
ASN A 302
LEU A 184
 None
 1.00A 2wekB-3o6xA:
undetectable		 2wekB-3o6xA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 3o6x GLUTAMINE SYNTHETASE
(Bacteroides
fragilis) 		3 / 3 GLU A 330
GLY A 477
SER A 392
 None
 0.70A 4b53B-3o6xA:
undetectable		 4b53B-3o6xA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A206_1
(UNCHARACTERIZED
PROTEIN)		 3o6x GLUTAMINE SYNTHETASE
(Bacteroides
fragilis) 		5 / 10 PHE A 169
TYR A 179
PRO A  93
ASN A 481
PHE A  91
 None
 1.41A 4kouA-3o6xA:
undetectable		 4kouA-3o6xA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3o6x GLUTAMINE SYNTHETASE
(Bacteroides
fragilis) 		4 / 8 GLU A 175
ILE A 170
ASP A 178
ILE A 168
 None
 0.89A 4kttB-3o6xA:
undetectable		 4kttB-3o6xA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 3o6x GLUTAMINE SYNTHETASE
(Bacteroides
fragilis) 		5 / 11 ASP A 422
LEU A 413
LEU A 372
LEU A 369
ILE A 527
 None
 1.04A 4odrA-3o6xA:
undetectable
4odrB-3o6xA:
undetectable		 4odrA-3o6xA:
9.90
4odrB-3o6xA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 3o6x GLUTAMINE SYNTHETASE
(Bacteroides
fragilis) 		4 / 8 LEU A 303
ASN A 302
MET A  41
ILE A 168
 None
 0.92A 4ok1A-3o6xA:
undetectable		 4ok1A-3o6xA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_H_SPMH202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3o6x GLUTAMINE SYNTHETASE
(Bacteroides
fragilis) 		4 / 6 GLU A 215
TYR A 218
GLU A 217
GLU A 286
 ADP  A4001 (-2.4A)
None
P3S  A3001 ( 3.2A)
MG  A2001 ( 2.8A)
 1.33A 4r87H-3o6xA:
undetectable		 4r87H-3o6xA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 3o6x GLUTAMINE SYNTHETASE
(Bacteroides
fragilis) 		4 / 7 SER A 540
PHE A 534
GLU A 546
GLU A 542
 None
 1.44A 4xzkA-3o6xA:
undetectable		 4xzkA-3o6xA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 3o6x GLUTAMINE SYNTHETASE
(Bacteroides
fragilis) 		3 / 3 ASP A  37
GLU A 299
SER A  81
 None
 0.82A 5bw4B-3o6xA:
undetectable		 5bw4B-3o6xA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 3o6x GLUTAMINE SYNTHETASE
(Bacteroides
fragilis) 		4 / 6 LEU A 123
LEU A 122
PHE A 105
LEU A 163
 None
 1.00A 5gs4A-3o6xA:
undetectable		 5gs4A-3o6xA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_F_EVPF102_1
(DNA TOPOISOMERASE
2-ALPHA)		 3o6x GLUTAMINE SYNTHETASE
(Bacteroides
fragilis) 		4 / 5 GLY A 394
ARG A 398
MET A 312
MET A 315
 None
P3S  A3001 (-3.8A)
None
None
 1.18A 5gwkA-3o6xA:
undetectable		 5gwkA-3o6xA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 3o6x GLUTAMINE SYNTHETASE
(Bacteroides
fragilis) 		4 / 8 ASN A 308
PHE A 328
GLU A 330
THR A 282
 None
 1.35A 5hqaA-3o6xA:
undetectable		 5hqaA-3o6xA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 3o6x GLUTAMINE SYNTHETASE
(Bacteroides
fragilis) 		5 / 12 ASP A 231
ARG A 229
LEU A 725
SER A 339
GLY A 236
 None
 1.27A 5il1A-3o6xA:
undetectable		 5il1A-3o6xA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3o6x GLUTAMINE SYNTHETASE
(Bacteroides
fragilis) 		4 / 9 TYR A 697
ILE A 701
ILE A 705
LEU A 708
 None
 0.82A 5vkqB-3o6xA:
3.5
5vkqC-3o6xA:
3.5		 5vkqB-3o6xA:
18.43
5vkqC-3o6xA:
18.43