SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o75'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR
(Pseudomonas
putida) 		4 / 8 GLY A 186
GLY A 200
PHE A 201
SER A 167
 None
 0.68A 1d0vA-3o75A:
undetectable		 1d0vA-3o75A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR
(Pseudomonas
putida) 		4 / 8 GLY A 186
GLY A 200
PHE A 201
SER A 167
 None
 0.67A 1jhaA-3o75A:
undetectable		 1jhaA-3o75A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR
(Pseudomonas
putida) 		6 / 9 GLY A 225
LEU A 228
SER A 221
GLU A 218
ARG A 188
GLY A 186
 None
 1.43A 1jhoA-3o75A:
undetectable		 1jhoA-3o75A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR
(Pseudomonas
putida) 		6 / 9 GLY A 225
LEU A 228
SER A 221
GLU A 218
ARG A 188
GLY A 186
 None
 1.42A 1jhrA-3o75A:
undetectable		 1jhrA-3o75A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR
(Pseudomonas
putida) 		6 / 9 GLY A 225
LEU A 228
SER A 221
GLU A 218
ARG A 188
GLY A 186
 None
 1.45A 1l5kA-3o75A:
undetectable		 1l5kA-3o75A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR
(Pseudomonas
putida) 		6 / 9 GLY A 225
LEU A 228
SER A 221
GLU A 218
ARG A 188
GLY A 186
 None
 1.44A 1l5lA-3o75A:
undetectable		 1l5lA-3o75A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR
(Pseudomonas
putida) 		6 / 9 GLY A 225
LEU A 228
SER A 221
GLU A 218
ARG A 188
GLY A 186
 None
 1.43A 1l5mA-3o75A:
undetectable		 1l5mA-3o75A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR
(Pseudomonas
putida) 		5 / 12 ALA A 120
LEU A 142
TYR A 313
LEU A 151
ILE A 147
 None
 1.06A 1s9pA-3o75A:
undetectable		 1s9pA-3o75A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR
(Pseudomonas
putida) 		5 / 12 ALA A 120
LEU A 142
TYR A 313
LEU A 151
ILE A 147
 None
 1.11A 1s9pD-3o75A:
undetectable		 1s9pD-3o75A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR
(Pseudomonas
putida) 		4 / 4 LEU A 175
LEU A 170
SER A 167
LEU A 184
 None
 1.18A 1ya3A-3o75A:
undetectable		 1ya3A-3o75A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR
(Pseudomonas
putida) 		5 / 12 GLY A 217
LEU A 250
LEU A 228
LEU A 191
LEU A 184
 None
 1.30A 1ya4B-3o75A:
2.9		 1ya4B-3o75A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR
(Pseudomonas
putida) 		4 / 5 ASP A 119
GLY A  91
ALA A 304
ILE A 308
 None
 0.81A 2aofA-3o75A:
undetectable		 2aofA-3o75A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR
(Pseudomonas
putida) 		4 / 5 ASP A 119
GLY A  91
ALA A 304
ILE A 308
 None
 0.83A 2aohB-3o75A:
undetectable		 2aohB-3o75A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_C_NCAC1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR
(Pseudomonas
putida) 		4 / 6 ARG A 149
SER A 125
ARG A 188
GLU A 106
 F1X  A   1 (-3.5A)
None
None
None
 1.36A 2c8aC-3o75A:
undetectable		 2c8aC-3o75A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_C_NCAC1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR
(Pseudomonas
putida) 		4 / 6 SER A 125
SER A  99
ARG A 188
GLU A 106
 None
 1.31A 2c8aC-3o75A:
undetectable		 2c8aC-3o75A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR
(Pseudomonas
putida) 		5 / 9 LEU A  94
LEU A  83
ILE A  79
PHE A  66
ILE A  96
 None
 1.18A 2f78A-3o75A:
3.1		 2f78A-3o75A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR
(Pseudomonas
putida) 		5 / 9 LEU A  94
LEU A  83
ILE A  79
PHE A  66
ILE A  96
 None
 1.19A 2f78B-3o75A:
2.9		 2f78B-3o75A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR
(Pseudomonas
putida) 		5 / 9 LEU A  94
LEU A  83
ILE A  79
PHE A  66
ILE A  96
 None
 1.22A 2f7aA-3o75A:
3.2		 2f7aA-3o75A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR
(Pseudomonas
putida) 		5 / 9 LEU A  94
LEU A  83
ILE A  79
PHE A  66
ILE A  96
 None
 1.26A 2f7aB-3o75A:
3.0		 2f7aB-3o75A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR
(Pseudomonas
putida) 		5 / 12 LEU A 258
SER A 265
GLN A 267
LEU A 270
LEU A 239
 None
 1.40A 3fsuA-3o75A:
undetectable		 3fsuA-3o75A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR
(Pseudomonas
putida) 		4 / 5 ILE A 185
THR A 245
THR A 246
SER A 247
 None
None
None
F1X  A   1 (-3.3A)
 0.95A 3snfA-3o75A:
undetectable		 3snfA-3o75A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR
(Pseudomonas
putida) 		3 / 3 TYR A 248
LEU A  83
LYS A  81
 None
 0.71A 3sueD-3o75A:
undetectable		 3sueD-3o75A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR
(Pseudomonas
putida) 		4 / 4 ASP A 235
ASP A 234
GLY A 238
THR A 257
 None
 1.08A 3tl9B-3o75A:
undetectable		 3tl9B-3o75A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR
(Pseudomonas
putida) 		5 / 12 LEU A 268
LEU A 232
PHE A 255
LEU A 251
ALA A 187
 None
 1.10A 3vw7A-3o75A:
undetectable		 3vw7A-3o75A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR
(Pseudomonas
putida) 		5 / 12 LEU A 239
LEU A 268
ILE A 233
GLN A 230
THR A 272
 None
 1.12A 4f4dA-3o75A:
4.3		 4f4dA-3o75A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR
(Pseudomonas
putida) 		6 / 9 GLY A 225
LEU A 228
SER A 221
GLU A 218
ARG A 188
GLY A 186
 None
 1.43A 4kqiA-3o75A:
undetectable		 4kqiA-3o75A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR
(Pseudomonas
putida) 		4 / 7 HIS A 293
ILE A 147
ILE A 296
ALA A 297
 None
 0.92A 4lv9B-3o75A:
undetectable		 4lv9B-3o75A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR
(Pseudomonas
putida) 		5 / 12 ALA A  87
LEU A  83
ILE A 145
ALA A 120
ILE A 147
 None
 0.89A 4o2bD-3o75A:
2.5		 4o2bD-3o75A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR
(Pseudomonas
putida) 		5 / 12 ALA A 187
THR A 257
GLY A 253
SER A 221
GLU A 223
 None
 1.39A 5hfjG-3o75A:
undetectable		 5hfjG-3o75A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR
(Pseudomonas
putida) 		4 / 5 GLY A 210
THR A 209
GLY A 274
LEU A 184
 None
None
F1X  A   1 (-3.1A)
None
 0.84A 5jlcA-3o75A:
1.1		 5jlcA-3o75A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR
(Pseudomonas
putida) 		5 / 12 ALA A  87
LEU A  83
ILE A 145
ALA A 120
ILE A 147
 None
 0.98A 5xiwB-3o75A:
undetectable		 5xiwB-3o75A:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR
(Pseudomonas
putida) 		4 / 8 LEU A 137
VAL A 123
LEU A 121
ILE A  67
 None
 0.85A 6cb4A-3o75A:
undetectable		 6cb4A-3o75A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR
(Pseudomonas
putida) 		6 / 12 LEU A 250
GLY A 186
PHE A 273
VAL A 244
LEU A 243
ILE A 182
 None
 1.10A 6ectA-3o75A:
3.2		 6ectA-3o75A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR
(Pseudomonas
putida) 		6 / 12 LEU A 250
GLY A 186
PHE A 273
VAL A 244
LEU A 243
ILE A 182
 None
 1.08A 6ecxA-3o75A:
undetectable		 6ecxA-3o75A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR
(Pseudomonas
putida) 		5 / 10 PHE A 220
ASN A 276
LEU A 278
ASP A 256
GLY A 253
 F1X  A   1 (-3.2A)
None
None
None
None
 1.36A 6r2eB-3o75A:
undetectable		 6r2eB-3o75A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR
(Pseudomonas
putida) 		5 / 10 PHE A 220
ASN A 276
LEU A 278
ASP A 256
GLY A 253
 F1X  A   1 (-3.2A)
None
None
None
None
 1.39A 6r2eD-3o75A:
undetectable		 6r2eD-3o75A:
21.70