SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o7b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQU_A_EQIA329_0
(PROTEIN (ESTRADIOL
17
BETA-DEHYDROGENASE
1))		 3o7b RIBOSOME BIOGENESIS
NEP1 RNA
METHYLTRANSFERASE
(Archaeoglobus
fulgidus) 		5 / 10 SER A   3
VAL A 164
LEU A 145
TYR A 210
GLY A 162
 None
 1.48A 1equA-3o7bA:
undetectable		 1equA-3o7bA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 3o7b RIBOSOME BIOGENESIS
NEP1 RNA
METHYLTRANSFERASE
(Archaeoglobus
fulgidus) 		5 / 12 VAL A  94
LEU A  73
SER A  75
LEU A 207
TYR A 210
 None
 1.36A 1mmkA-3o7bA:
undetectable		 1mmkA-3o7bA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 3o7b RIBOSOME BIOGENESIS
NEP1 RNA
METHYLTRANSFERASE
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 138
LEU A 146
VAL A 144
GLU A 183
LEU A 184
 None
 1.14A 2bxfA-3o7bA:
undetectable		 2bxfA-3o7bA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 3o7b RIBOSOME BIOGENESIS
NEP1 RNA
METHYLTRANSFERASE
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 127
ILE A 128
ASN A  95
VAL A  82
LEU A  73
 None
 1.26A 2bxfB-3o7bA:
undetectable		 2bxfB-3o7bA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 3o7b RIBOSOME BIOGENESIS
NEP1 RNA
METHYLTRANSFERASE
(Archaeoglobus
fulgidus) 		3 / 3 ARG A  59
GLN A  17
PRO A  16
 None
 0.81A 2qhfA-3o7bA:
undetectable		 2qhfA-3o7bA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 3o7b RIBOSOME BIOGENESIS
NEP1 RNA
METHYLTRANSFERASE
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 120
ASP A  74
ARG A 102
LEU A  69
ILE A 128
 None
 1.00A 4m2xA-3o7bA:
undetectable		 4m2xA-3o7bA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 3o7b RIBOSOME BIOGENESIS
NEP1 RNA
METHYLTRANSFERASE
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 120
ASP A  74
ARG A 102
LEU A  69
ILE A 128
 None
 1.00A 4m2xE-3o7bA:
undetectable		 4m2xE-3o7bA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 3o7b RIBOSOME BIOGENESIS
NEP1 RNA
METHYLTRANSFERASE
(Archaeoglobus
fulgidus) 		3 / 3 GLU A   9
ALA A  10
PHE A 171
 None
None
SAH  A 301 (-4.3A)
 0.66A 4v1fA-3o7bA:
undetectable		 4v1fA-3o7bA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 3o7b RIBOSOME BIOGENESIS
NEP1 RNA
METHYLTRANSFERASE
(Archaeoglobus
fulgidus) 		3 / 3 GLU A   9
ALA A  10
PHE A 171
 None
None
SAH  A 301 (-4.3A)
 0.65A 4v1fC-3o7bA:
undetectable		 4v1fC-3o7bA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3o7b RIBOSOME BIOGENESIS
NEP1 RNA
METHYLTRANSFERASE
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 168
GLY A 169
SER A 191
LEU A 192
VAL A 202
 SAH  A 301 (-4.6A)
SAH  A 301 (-3.3A)
TYR  A 220 ( 3.5A)
SAH  A 301 ( 4.1A)
SAH  A 301 (-4.7A)
 0.38A 5twjA-3o7bA:
7.4		 5twjA-3o7bA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3o7b RIBOSOME BIOGENESIS
NEP1 RNA
METHYLTRANSFERASE
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 168
GLY A 169
SER A 191
LEU A 192
VAL A 202
 SAH  A 301 (-4.6A)
SAH  A 301 (-3.3A)
TYR  A 220 ( 3.5A)
SAH  A 301 ( 4.1A)
SAH  A 301 (-4.7A)
 0.38A 5twjC-3o7bA:
7.3		 5twjC-3o7bA:
23.79