SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o7o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDT_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 3o7o ENDOGLUCANASE
(Thermotoga
maritima) 		5 / 11 SER A  92
VAL A 256
LEU A 254
TYR A  71
SER A  84
 None
 1.31A 1fdtA-3o7oA:
undetectable		 1fdtA-3o7oA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 3o7o ENDOGLUCANASE
(Thermotoga
maritima) 		4 / 7 GLY A 234
PHE A 243
ILE A  51
PHE A  47
 None
 0.99A 2qmzA-3o7oA:
undetectable
2qmzB-3o7oA:
undetectable		 2qmzA-3o7oA:
23.49
2qmzB-3o7oA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3o7o ENDOGLUCANASE
(Thermotoga
maritima) 		3 / 3 TYR A 181
GLU A 117
ASN A  25
 None
 0.91A 2y7hC-3o7oA:
undetectable		 2y7hC-3o7oA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_K_SAMK302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3o7o ENDOGLUCANASE
(Thermotoga
maritima) 		5 / 12 LEU A 210
LEU A 203
SER A 213
LEU A 182
LEU A 174
 None
 1.50A 3cjtK-3o7oA:
undetectable		 3cjtK-3o7oA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 3o7o ENDOGLUCANASE
(Thermotoga
maritima) 		5 / 12 THR A 225
PHE A  69
GLY A  72
ILE A  18
VAL A  98
 None
 1.14A 3fzgA-3o7oA:
undetectable		 3fzgA-3o7oA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 3o7o ENDOGLUCANASE
(Thermotoga
maritima) 		4 / 7 PHE A 224
GLY A  72
ILE A 252
LEU A 254
 None
 0.76A 4ejjD-3o7oA:
undetectable		 4ejjD-3o7oA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3o7o ENDOGLUCANASE
(Thermotoga
maritima) 		5 / 6 PHE A 197
ILE A 157
PRO A 158
PHE A 159
PHE A 140
 None
 1.47A 4fgkA-3o7oA:
undetectable		 4fgkA-3o7oA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_E_CAME502_0
(CAMPHOR
5-MONOOXYGENASE)		 3o7o ENDOGLUCANASE
(Thermotoga
maritima) 		4 / 5 PHE A 114
THR A  46
PHE A  69
ILE A 104
 None
 1.12A 4jx1E-3o7oA:
undetectable		 4jx1E-3o7oA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3o7o ENDOGLUCANASE
(Thermotoga
maritima) 		4 / 6 GLY A 234
PHE A 243
ILE A  51
PHE A  47
 None
 1.04A 4qogA-3o7oA:
undetectable
4qogB-3o7oA:
undetectable		 4qogA-3o7oA:
23.76
4qogB-3o7oA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_C_EF2C151_1
(CEREBLON ISOFORM 4)		 3o7o ENDOGLUCANASE
(Thermotoga
maritima) 		4 / 7 ASN A  25
PRO A  67
PHE A  47
PHE A  13
 None
 1.43A 4v32C-3o7oA:
undetectable		 4v32C-3o7oA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 3o7o ENDOGLUCANASE
(Thermotoga
maritima) 		3 / 3 VAL A 134
PHE A 224
ARG A 200
 None
 0.97A 4xr4B-3o7oA:
undetectable		 4xr4B-3o7oA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3o7o ENDOGLUCANASE
(Thermotoga
maritima) 		5 / 9 LEU A  20
ILE A 252
PHE A  13
VAL A   3
GLU A  68
 None
 1.50A 5igzA-3o7oA:
undetectable		 5igzA-3o7oA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3o7o ENDOGLUCANASE
(Thermotoga
maritima) 		4 / 5 TYR A  32
VAL A  36
ASP A  50
ALA A  49
 None
 1.06A 5otrA-3o7oA:
undetectable		 5otrA-3o7oA:
19.48