SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o7w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Homo
sapiens) 		5 / 12 ALA A  33
GLY A  98
GLY A 100
CYH A 199
TYR A 203
 SAM  A 801 (-3.6A)
SAM  A 801 (-3.5A)
SAM  A 801 ( 3.7A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.6A)
 0.50A 1rjdA-3o7wA:
30.7		 1rjdA-3o7wA:
29.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Homo
sapiens) 		4 / 6 ARG A  73
ASP A 122
ASP A 171
GLU A 198
 SAM  A 801 (-3.8A)
SAM  A 801 (-2.7A)
SAM  A 801 (-3.8A)
SAM  A 801 (-3.1A)
 0.19A 1rjdA-3o7wA:
30.7		 1rjdA-3o7wA:
29.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Homo
sapiens) 		5 / 12 ALA A  33
GLY A  98
GLY A 100
CYH A 199
TYR A 203
 SAM  A 801 (-3.6A)
SAM  A 801 (-3.5A)
SAM  A 801 ( 3.7A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.6A)
 0.54A 1rjdB-3o7wA:
30.3		 1rjdB-3o7wA:
29.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Homo
sapiens) 		5 / 12 ALA A  33
GLY A  98
GLY A 100
LEU A 172
CYH A 199
 SAM  A 801 (-3.6A)
SAM  A 801 (-3.5A)
SAM  A 801 ( 3.7A)
SAM  A 801 (-3.7A)
SAM  A 801 (-4.9A)
 0.51A 1rjdB-3o7wA:
30.3		 1rjdB-3o7wA:
29.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Homo
sapiens) 		4 / 6 ARG A  73
ASP A 122
ASP A 171
GLU A 198
 SAM  A 801 (-3.8A)
SAM  A 801 (-2.7A)
SAM  A 801 (-3.8A)
SAM  A 801 (-3.1A)
 0.21A 1rjdB-3o7wA:
30.3		 1rjdB-3o7wA:
29.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Homo
sapiens) 		5 / 12 ALA A  33
GLY A  98
GLY A 100
CYH A 199
TYR A 203
 SAM  A 801 (-3.6A)
SAM  A 801 (-3.5A)
SAM  A 801 ( 3.7A)
SAM  A 801 (-4.9A)
SAM  A 801 (-4.6A)
 0.54A 1rjdC-3o7wA:
30.5		 1rjdC-3o7wA:
29.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Homo
sapiens) 		4 / 6 ARG A  73
ASP A 122
ASP A 171
GLU A 198
 SAM  A 801 (-3.8A)
SAM  A 801 (-2.7A)
SAM  A 801 (-3.8A)
SAM  A 801 (-3.1A)
 0.20A 1rjdC-3o7wA:
30.5		 1rjdC-3o7wA:
29.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC1383_1
(CES1 PROTEIN)		 3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Homo
sapiens) 		4 / 5 TRP A 319
LEU A 329
GLY A 328
LYS A  87
 None
 1.25A 1ya4C-3o7wA:
0.7		 1ya4C-3o7wA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Homo
sapiens) 		3 / 3 SER A 219
VAL A  95
LEU A 195
 None
 0.73A 1yajG-3o7wA:
undetectable		 1yajG-3o7wA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Homo
sapiens) 		3 / 3 TRP A 319
LEU A 329
LYS A  87
 None
 1.34A 1yajK-3o7wA:
2.5		 1yajK-3o7wA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Homo
sapiens) 		5 / 12 GLY A  98
GLY A 100
ASP A 171
ARG A 173
TYR A 203
 SAM  A 801 (-3.5A)
SAM  A 801 ( 3.7A)
SAM  A 801 (-3.8A)
None
SAM  A 801 (-4.6A)
 0.39A 2qe6A-3o7wA:
16.1		 2qe6A-3o7wA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Homo
sapiens) 		5 / 12 GLY A  98
GLY A 100
ASP A 171
ARG A 173
TYR A 203
 SAM  A 801 (-3.5A)
SAM  A 801 ( 3.7A)
SAM  A 801 (-3.8A)
None
SAM  A 801 (-4.6A)
 0.35A 2qe6B-3o7wA:
16.0		 2qe6B-3o7wA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Homo
sapiens) 		6 / 12 GLY A  98
GLY A 100
ASP A 102
LEU A 172
TYR A 203
MET A 204
 SAM  A 801 (-3.5A)
SAM  A 801 ( 3.7A)
None
SAM  A 801 (-3.7A)
SAM  A 801 (-4.6A)
None
 0.75A 2zw9A-3o7wA:
28.0		 2zw9A-3o7wA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Homo
sapiens) 		5 / 12 SER A  34
GLY A  98
GLY A 100
ASP A 102
LEU A 172
 None
SAM  A 801 (-3.5A)
SAM  A 801 ( 3.7A)
None
SAM  A 801 (-3.7A)
 1.16A 2zw9A-3o7wA:
28.0		 2zw9A-3o7wA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Homo
sapiens) 		5 / 8 LYS A  37
ARG A  73
ASP A 122
ASP A 171
GLU A 198
 SAM  A 801 (-2.6A)
SAM  A 801 (-3.8A)
SAM  A 801 (-2.7A)
SAM  A 801 (-3.8A)
SAM  A 801 (-3.1A)
 0.36A 2zw9A-3o7wA:
28.0		 2zw9A-3o7wA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Homo
sapiens) 		8 / 12 GLY A  98
GLY A 100
ASP A 102
ASP A 171
LEU A 172
GLU A 198
TYR A 203
MET A 204
 SAM  A 801 (-3.5A)
SAM  A 801 ( 3.7A)
None
SAM  A 801 (-3.8A)
SAM  A 801 (-3.7A)
SAM  A 801 (-3.1A)
SAM  A 801 (-4.6A)
None
 0.78A 2zw9B-3o7wA:
14.5		 2zw9B-3o7wA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Homo
sapiens) 		3 / 3 VAL A 127
LYS A 130
HIS A 148
 None
 0.87A 3elzA-3o7wA:
undetectable		 3elzA-3o7wA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGI_A_BEZA284_0
(CATECHOL
1,2-DIOXYGENASE)		 3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Homo
sapiens) 		5 / 12 LEU A  97
ASP A 122
VAL A 121
GLY A 100
TYR A 118
 None
SAM  A 801 (-2.7A)
None
SAM  A 801 ( 3.7A)
None
 1.37A 3hgiA-3o7wA:
undetectable		 3hgiA-3o7wA:
21.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Homo
sapiens) 		12 / 12 ALA A  33
GLY A  98
GLY A 100
PHE A 123
ILE A 126
ASP A 171
LEU A 172
ARG A 173
GLU A 198
CYH A 199
VAL A 200
TYR A 203
 SAM  A 801 (-3.6A)
SAM  A 801 (-3.5A)
SAM  A 801 ( 3.7A)
SAM  A 801 (-3.7A)
SAM  A 801 (-4.3A)
SAM  A 801 (-3.8A)
SAM  A 801 (-3.7A)
None
SAM  A 801 (-3.1A)
SAM  A 801 (-4.9A)
SAM  A 801 ( 3.9A)
SAM  A 801 (-4.6A)
 0.02A 3o7wA-3o7wA:
51.6		 3o7wA-3o7wA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Homo
sapiens) 		3 / 3 LYS A  37
ARG A  73
ASP A 122
 SAM  A 801 (-2.6A)
SAM  A 801 (-3.8A)
SAM  A 801 (-2.7A)
 0.01A 3o7wA-3o7wA:
51.6		 3o7wA-3o7wA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Homo
sapiens) 		3 / 3 GLY A 100
ASP A 122
ASP A 171
 SAM  A 801 ( 3.7A)
SAM  A 801 (-2.7A)
SAM  A 801 (-3.8A)
 0.37A 3ou7C-3o7wA:
9.9		 3ou7C-3o7wA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Homo
sapiens) 		5 / 12 LEU A 172
TYR A 203
GLY A 100
LEU A  97
ASP A 122
 SAM  A 801 (-3.7A)
SAM  A 801 (-4.6A)
SAM  A 801 ( 3.7A)
None
SAM  A 801 (-2.7A)
 1.08A 4blvA-3o7wA:
9.8		 4blvA-3o7wA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_2
(PROTEASE)		 3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Homo
sapiens) 		5 / 10 LEU A 329
ALA A  83
ILE A  94
THR A 321
ILE A 332
 None
 1.07A 4njuB-3o7wA:
undetectable		 4njuB-3o7wA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_2
(PROTEASE)		 3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Homo
sapiens) 		5 / 10 LEU A 329
ALA A  83
ILE A  94
THR A 321
ILE A 332
 None
 1.07A 4njuD-3o7wA:
undetectable		 4njuD-3o7wA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Homo
sapiens) 		4 / 6 TYR A 203
LEU A 212
GLU A 229
ALA A 320
 SAM  A 801 (-4.6A)
None
None
None
 0.91A 4nkvC-3o7wA:
undetectable		 4nkvC-3o7wA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Homo
sapiens) 		4 / 5 PHE A 220
PRO A 192
ALA A 223
PHE A  84
 None
 1.02A 4w5oA-3o7wA:
2.2		 4w5oA-3o7wA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Homo
sapiens) 		4 / 5 PHE A 220
PRO A 192
ALA A 223
PHE A  84
 None
 1.02A 4z4cA-3o7wA:
undetectable		 4z4cA-3o7wA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Homo
sapiens) 		4 / 5 PHE A 220
PRO A 192
ALA A 223
PHE A  84
 None
 1.03A 4z4dA-3o7wA:
2.3		 4z4dA-3o7wA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Homo
sapiens) 		4 / 5 PHE A 220
PRO A 192
ALA A 223
PHE A  84
 None
 1.02A 4z4eA-3o7wA:
2.1		 4z4eA-3o7wA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Homo
sapiens) 		5 / 12 GLY A  98
TYR A 203
ASP A 122
ALA A  99
ASP A 102
 SAM  A 801 (-3.5A)
SAM  A 801 (-4.6A)
SAM  A 801 (-2.7A)
None
None
 1.19A 5kvaA-3o7wA:
9.3		 5kvaA-3o7wA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Homo
sapiens) 		5 / 12 GLY A  98
TYR A 203
ASP A 122
ALA A  99
ASP A 102
 SAM  A 801 (-3.5A)
SAM  A 801 (-4.6A)
SAM  A 801 (-2.7A)
None
None
 1.21A 5kvaB-3o7wA:
9.5		 5kvaB-3o7wA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Homo
sapiens) 		5 / 12 LEU A 201
LEU A 213
ALA A 216
SER A 219
ARG A 173
 None
 1.19A 5nd7B-3o7wA:
undetectable		 5nd7B-3o7wA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Homo
sapiens) 		3 / 3 HIS A  75
SER A  78
LYS A  82
 None
 1.49A 5os7A-3o7wA:
undetectable		 5os7A-3o7wA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Homo
sapiens) 		4 / 6 PHE A 220
PRO A 192
ALA A 223
PHE A  84
 None
 1.02A 5t7bA-3o7wA:
2.2		 5t7bA-3o7wA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1
(Homo
sapiens) 		3 / 3 HIS A  75
SER A  78
LYS A  82
 None
 1.49A 6gmdB-3o7wA:
undetectable		 6gmdB-3o7wA:
22.31