SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o80'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 3o80 HEXOKINASE
(Kluyveromyces
lactis) 		5 / 10 GLY A 228
ASN A 236
LEU A 219
VAL A 216
ASP A 222
 None
 1.27A 1fpqA-3o80A:
undetectable		 1fpqA-3o80A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3o80 HEXOKINASE
(Kluyveromyces
lactis) 		4 / 6 ASN A 266
ALA A 238
GLY A 237
TYR A 239
 None
 1.12A 1l5qA-3o80A:
undetectable		 1l5qA-3o80A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3o80 HEXOKINASE
(Kluyveromyces
lactis) 		4 / 6 ASN A 266
ALA A 238
GLY A 237
TYR A 239
 None
 1.14A 1l5qB-3o80A:
2.7		 1l5qB-3o80A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3o80 HEXOKINASE
(Kluyveromyces
lactis) 		4 / 6 ASN A 266
ALA A 238
GLY A 237
TYR A 239
 None
 1.14A 1l7xA-3o80A:
undetectable		 1l7xA-3o80A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3o80 HEXOKINASE
(Kluyveromyces
lactis) 		4 / 6 ASN A 266
ALA A 238
GLY A 237
TYR A 239
 None
 1.12A 1l7xB-3o80A:
undetectable		 1l7xB-3o80A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 3o80 HEXOKINASE
(Kluyveromyces
lactis) 		5 / 9 TYR A 269
GLY A 237
TYR A 239
ILE A 402
ALA A 401
 None
 1.26A 1mrgA-3o80A:
undetectable		 1mrgA-3o80A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 3o80 HEXOKINASE
(Kluyveromyces
lactis) 		3 / 3 THR A  35
GLU A 385
ASP A 352
 ANP  A 487 (-4.2A)
None
None
 0.83A 1nt2A-3o80A:
undetectable		 1nt2A-3o80A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 3o80 HEXOKINASE
(Kluyveromyces
lactis) 		4 / 6 MET A 313
VAL A 316
LEU A 317
PHE A 327
 None
 1.14A 1x8vA-3o80A:
1.1		 1x8vA-3o80A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 3o80 HEXOKINASE
(Kluyveromyces
lactis) 		5 / 12 ILE A 349
MET A 313
ARG A 390
LEU A 379
PHE A 364
 None
 1.41A 1y0xX-3o80A:
undetectable		 1y0xX-3o80A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3o80 HEXOKINASE
(Kluyveromyces
lactis) 		4 / 7 TYR A 269
VAL A 396
CYH A 403
ILE A 413
 None
 1.33A 2xz5B-3o80A:
undetectable
2xz5E-3o80A:
undetectable		 2xz5B-3o80A:
18.52
2xz5E-3o80A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3o80 HEXOKINASE
(Kluyveromyces
lactis) 		4 / 8 ILE A 413
TYR A 269
VAL A 396
CYH A 403
 None
 1.26A 2xz5A-3o80A:
undetectable
2xz5C-3o80A:
undetectable		 2xz5A-3o80A:
18.52
2xz5C-3o80A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3o80 HEXOKINASE
(Kluyveromyces
lactis) 		4 / 8 ILE A 413
TYR A 269
VAL A 396
CYH A 403
 None
 1.25A 2xz5C-3o80A:
undetectable
2xz5D-3o80A:
undetectable		 2xz5C-3o80A:
18.52
2xz5D-3o80A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3o80 HEXOKINASE
(Kluyveromyces
lactis) 		4 / 7 ILE A 413
TYR A 269
VAL A 396
CYH A 403
 None
 1.26A 2xz5D-3o80A:
undetectable
2xz5E-3o80A:
undetectable		 2xz5D-3o80A:
18.52
2xz5E-3o80A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		 3o80 HEXOKINASE
(Kluyveromyces
lactis) 		4 / 5 ASN A 266
ALA A 238
GLY A 237
TYR A 239
 None
 1.13A 3bcrA-3o80A:
undetectable		 3bcrA-3o80A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)		 3o80 HEXOKINASE
(Kluyveromyces
lactis) 		4 / 5 VAL A  70
VAL A  71
THR A 470
ARG A 473
 None
 1.13A 3bjwA-3o80A:
undetectable		 3bjwA-3o80A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_1
(PHOSPHOLIPASE A2)		 3o80 HEXOKINASE
(Kluyveromyces
lactis) 		4 / 5 VAL A  70
VAL A  71
THR A 470
ARG A 473
 None
 1.20A 3bjwC-3o80A:
undetectable		 3bjwC-3o80A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3o80 HEXOKINASE
(Kluyveromyces
lactis) 		4 / 4 SER A 418
GLY A 417
GLY A 306
GLY A 234
 None
 0.89A 3bogB-3o80A:
undetectable
3bogD-3o80A:
undetectable		 3bogB-3o80A:
undetectable
3bogD-3o80A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3o80 HEXOKINASE
(Kluyveromyces
lactis) 		4 / 6 ASN A 266
ALA A 238
GLY A 237
TYR A 239
 None
 1.11A 3dd1A-3o80A:
undetectable		 3dd1A-3o80A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_A_CFFA904_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3o80 HEXOKINASE
(Kluyveromyces
lactis) 		4 / 6 ASN A 266
ALA A 238
GLY A 237
TYR A 239
 None
 1.13A 3ddsA-3o80A:
undetectable		 3ddsA-3o80A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3o80 HEXOKINASE
(Kluyveromyces
lactis) 		4 / 6 ASN A 266
ALA A 238
GLY A 237
TYR A 239
 None
 1.15A 3ddsB-3o80A:
undetectable		 3ddsB-3o80A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3o80 HEXOKINASE
(Kluyveromyces
lactis) 		4 / 6 ASN A 266
ALA A 238
GLY A 237
TYR A 239
 None
 1.14A 3ddwA-3o80A:
undetectable		 3ddwA-3o80A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3o80 HEXOKINASE
(Kluyveromyces
lactis) 		3 / 3 ALA A  84
ARG A  93
LYS A 111
 None
 1.08A 3kp5B-3o80A:
undetectable		 3kp5B-3o80A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3o80 HEXOKINASE
(Kluyveromyces
lactis) 		5 / 12 ILE A 402
VAL A  36
ILE A  63
VAL A 278
LEU A 279
 None
ANP  A 487 (-4.4A)
None
None
None
 1.19A 3w68C-3o80A:
undetectable		 3w68C-3o80A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 3o80 HEXOKINASE
(Kluyveromyces
lactis) 		4 / 8 VAL A 396
CYH A 403
ILE A 437
ILE A 450
 None
 1.02A 4afgD-3o80A:
undetectable
4afgE-3o80A:
undetectable		 4afgD-3o80A:
19.10
4afgE-3o80A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3o80 HEXOKINASE
(Kluyveromyces
lactis) 		4 / 8 TYR A 269
VAL A 396
CYH A 403
ILE A 413
 None
 1.20A 4bqtC-3o80A:
undetectable
4bqtD-3o80A:
undetectable		 4bqtC-3o80A:
18.52
4bqtD-3o80A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 3o80 HEXOKINASE
(Kluyveromyces
lactis) 		4 / 8 TYR A 284
LEU A  33
LEU A  30
GLY A  29
 None
 0.73A 4c9nA-3o80A:
2.3		 4c9nA-3o80A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3o80 HEXOKINASE
(Kluyveromyces
lactis) 		5 / 9 THR A 155
THR A 212
ALA A 238
GLY A 460
GLY A 462
 None
 1.19A 4qwuK-3o80A:
undetectable
4qwuL-3o80A:
undetectable		 4qwuK-3o80A:
20.41
4qwuL-3o80A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3o80 HEXOKINASE
(Kluyveromyces
lactis) 		4 / 8 ILE A 165
LEU A 249
LEU A 252
MET A 263
 None
 0.96A 4xtaB-3o80A:
undetectable		 4xtaB-3o80A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 3o80 HEXOKINASE
(Kluyveromyces
lactis) 		4 / 7 ILE A 202
LEU A  85
ALA A 131
ILE A 200
 None
 0.85A 4y03A-3o80A:
undetectable		 4y03A-3o80A:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3o80 HEXOKINASE
(Kluyveromyces
lactis) 		5 / 12 LEU A 170
ILE A 130
GLU A 180
LEU A 152
PHE A 154
 None
 1.12A 4y0qA-3o80A:
undetectable		 4y0qA-3o80A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3o80 HEXOKINASE
(Kluyveromyces
lactis) 		5 / 9 TYR A 284
ILE A 288
GLY A 310
LEU A 383
LEU A  30
 None
 1.37A 4ze0A-3o80A:
undetectable		 4ze0A-3o80A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3o80 HEXOKINASE
(Kluyveromyces
lactis) 		4 / 7 TYR A 284
ILE A 288
GLY A 310
LEU A 383
 None
 0.95A 5esmA-3o80A:
undetectable		 5esmA-3o80A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3o80 HEXOKINASE
(Kluyveromyces
lactis) 		5 / 11 ILE A 130
GLN A 125
PHE A 129
LEU A 126
VAL A  94
 None
 1.18A 5ji0A-3o80A:
undetectable		 5ji0A-3o80A:
19.13