SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o8j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3o8j 2-METHYLCITRATE
SYNTHASE
(Salmonella
enterica) 		4 / 5 SER A 185
THR A 183
GLU A 297
GLY A 298
 GOL  A 409 (-3.1A)
None
GOL  A 409 ( 4.4A)
None
 1.30A 1icrA-3o8jA:
undetectable
1icrB-3o8jA:
undetectable		 1icrA-3o8jA:
17.73
1icrB-3o8jA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3o8j 2-METHYLCITRATE
SYNTHASE
(Salmonella
enterica) 		4 / 5 GLU A 297
GLY A 298
SER A 185
THR A 183
 GOL  A 409 ( 4.4A)
None
GOL  A 409 (-3.1A)
None
 1.31A 1icrA-3o8jA:
undetectable
1icrB-3o8jA:
undetectable		 1icrA-3o8jA:
17.73
1icrB-3o8jA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3o8j 2-METHYLCITRATE
SYNTHASE
(Salmonella
enterica) 		4 / 5 SER A 185
THR A 183
GLU A 297
GLY A 298
 GOL  A 409 (-3.1A)
None
GOL  A 409 ( 4.4A)
None
 1.30A 1icvC-3o8jA:
undetectable
1icvD-3o8jA:
undetectable		 1icvC-3o8jA:
17.73
1icvD-3o8jA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3o8j 2-METHYLCITRATE
SYNTHASE
(Salmonella
enterica) 		4 / 5 GLU A 297
GLY A 298
SER A 185
THR A 183
 GOL  A 409 ( 4.4A)
None
GOL  A 409 (-3.1A)
None
 1.31A 1icvC-3o8jA:
undetectable
1icvD-3o8jA:
undetectable		 1icvC-3o8jA:
17.73
1icvD-3o8jA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 3o8j 2-METHYLCITRATE
SYNTHASE
(Salmonella
enterica) 		5 / 9 LEU A  42
HIS A  55
ALA A  53
GLU A  60
LEU A  70
 None
 1.12A 2azqA-3o8jA:
undetectable		 2azqA-3o8jA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 3o8j 2-METHYLCITRATE
SYNTHASE
(Salmonella
enterica) 		4 / 4 LEU A  76
THR A  72
ILE A  66
HIS A  67
 None
 1.33A 2jfaB-3o8jA:
undetectable		 2jfaB-3o8jA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 3o8j 2-METHYLCITRATE
SYNTHASE
(Salmonella
enterica) 		3 / 3 ARG A  94
GLN A 161
PRO A 162
 None
 0.93A 2qhfA-3o8jA:
undetectable		 2qhfA-3o8jA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 3o8j 2-METHYLCITRATE
SYNTHASE
(Salmonella
enterica) 		4 / 7 SER A 331
LEU A 194
ILE A 287
GLY A 170
 None
 0.69A 2v0mC-3o8jA:
undetectable		 2v0mC-3o8jA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 3o8j 2-METHYLCITRATE
SYNTHASE
(Salmonella
enterica) 		5 / 11 MET A 110
LEU A 345
LEU A 143
ILE A 348
THR A 352
 None
 1.31A 3a50B-3o8jA:
1.4		 3a50B-3o8jA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 3o8j 2-METHYLCITRATE
SYNTHASE
(Salmonella
enterica) 		5 / 12 PRO A 106
MET A 110
ILE A 227
LEU A 345
ILE A 348
 None
 1.22A 3a50E-3o8jA:
undetectable		 3a50E-3o8jA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 3o8j 2-METHYLCITRATE
SYNTHASE
(Salmonella
enterica) 		6 / 12 PRO A 106
MET A 110
LEU A 345
LEU A 143
ILE A 348
THR A 352
 None
 1.44A 3a50E-3o8jA:
undetectable		 3a50E-3o8jA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 3o8j 2-METHYLCITRATE
SYNTHASE
(Salmonella
enterica) 		4 / 6 LEU A  86
SER A 142
LEU A 143
LEU A  83
 None
 1.05A 3f33A-3o8jA:
undetectable		 3f33A-3o8jA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K17_B_OHBB701_0
(LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A)		 3o8j 2-METHYLCITRATE
SYNTHASE
(Salmonella
enterica) 		4 / 5 GLU A 163
SER A 142
PRO A 162
SER A 145
 None
 1.21A 4k17B-3o8jA:
undetectable		 4k17B-3o8jA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_A_198A601_1
(SERUM ALBUMIN)		 3o8j 2-METHYLCITRATE
SYNTHASE
(Salmonella
enterica) 		5 / 10 LEU A  76
ALA A 198
PHE A  58
GLU A  60
LEU A  83
 None
 1.46A 4la0A-3o8jA:
undetectable		 4la0A-3o8jA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_B_198B601_1
(SERUM ALBUMIN)		 3o8j 2-METHYLCITRATE
SYNTHASE
(Salmonella
enterica) 		5 / 9 LEU A  76
ALA A 198
PHE A  58
GLU A  60
LEU A  83
 None
 1.43A 4la0B-3o8jA:
undetectable		 4la0B-3o8jA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 3o8j 2-METHYLCITRATE
SYNTHASE
(Salmonella
enterica) 		4 / 5 LEU A 139
VAL A  93
VAL A 109
TYR A 220
 None
 0.93A 4r7iA-3o8jA:
undetectable		 4r7iA-3o8jA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3o8j 2-METHYLCITRATE
SYNTHASE
(Salmonella
enterica) 		4 / 5 GLN A 285
PRO A 282
ILE A  49
ASP A  48
 None
 1.44A 4z4hA-3o8jA:
2.3		 4z4hA-3o8jA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3o8j 2-METHYLCITRATE
SYNTHASE
(Salmonella
enterica) 		5 / 10 ILE A 223
ILE A 227
LEU A 230
HIS A  67
ILE A  66
 None
 1.18A 5vkqA-3o8jA:
undetectable
5vkqD-3o8jA:
undetectable		 5vkqA-3o8jA:
12.90
5vkqD-3o8jA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3o8j 2-METHYLCITRATE
SYNTHASE
(Salmonella
enterica) 		5 / 10 HIS A  67
ILE A  66
ILE A 223
ILE A 227
LEU A 230
 None
 1.19A 5vkqA-3o8jA:
undetectable
5vkqB-3o8jA:
undetectable		 5vkqA-3o8jA:
12.90
5vkqB-3o8jA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3o8j 2-METHYLCITRATE
SYNTHASE
(Salmonella
enterica) 		5 / 9 HIS A  67
ILE A  66
ILE A 223
ILE A 227
LEU A 230
 None
 1.17A 5vkqB-3o8jA:
1.9
5vkqC-3o8jA:
1.9		 5vkqB-3o8jA:
12.90
5vkqC-3o8jA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3o8j 2-METHYLCITRATE
SYNTHASE
(Salmonella
enterica) 		5 / 10 HIS A  67
ILE A  66
ILE A 223
ILE A 227
LEU A 230
 None
 1.19A 5vkqC-3o8jA:
undetectable
5vkqD-3o8jA:
undetectable		 5vkqC-3o8jA:
12.90
5vkqD-3o8jA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 3o8j 2-METHYLCITRATE
SYNTHASE
(Salmonella
enterica) 		4 / 6 GLN A 246
MET A 335
VAL A 330
LEU A 294
 None
 1.20A 5xdhA-3o8jA:
0.0
5xdhC-3o8jA:
0.1		 5xdhA-3o8jA:
10.61
5xdhC-3o8jA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA606_0
(ALPHA-AMYLASE)		 3o8j 2-METHYLCITRATE
SYNTHASE
(Salmonella
enterica) 		5 / 7 GLY A 228
GLY A 232
PRO A 233
GLY A 237
GLY A 236
 None
 0.84A 6ag0A-3o8jA:
undetectable		 6ag0A-3o8jA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HXI_B_ACTB706_0
(SUCCINYL-COA LIGASE
(ADP-FORMING)
SUBUNIT ALPHA)		 3o8j 2-METHYLCITRATE
SYNTHASE
(Salmonella
enterica) 		4 / 5 HIS A 200
ARG A 283
PHE A 346
ARG A 350
 None
 0.42A 6hxiB-3o8jA:
15.0		 6hxiB-3o8jA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HXI_D_ACTD703_0
(SUCCINYL-COA LIGASE
(ADP-FORMING)
SUBUNIT ALPHA)		 3o8j 2-METHYLCITRATE
SYNTHASE
(Salmonella
enterica) 		5 / 5 HIS A 200
ARG A 283
ASP A 325
PHE A 346
ARG A 350
 None
 0.52A 6hxiD-3o8jA:
16.5		 6hxiD-3o8jA:
22.87