SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o8l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
4 / 8 LEU A 711
ILE A 425
VAL A 523
ILE A 525
None
0.71A 1d4yB-3o8lA:
undetectable
1d4yB-3o8lA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4003_1
(SERUM ALBUMIN)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
4 / 6 VAL A 159
GLY A 160
ALA A 320
LEU A 324
None
0.77A 1e7bB-3o8lA:
undetectable
1e7bB-3o8lA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 GLY A 468
LEU A 467
GLY A 442
TYR A 455
VAL A 423
None
1.17A 1fduC-3o8lA:
4.2
1fduC-3o8lA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_2
(PROTEASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
6 / 12 GLY A 224
ALA A 225
ASP A 226
ILE A 192
VAL A 207
ILE A 261
PO4  A 767 ( 4.6A)
None
None
None
None
None
1.08A 1muiB-3o8lA:
undetectable
1muiB-3o8lA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 PHE A 675
SER A 222
VAL A 218
ALA A 418
ALA A 417
None
1.08A 1nw5A-3o8lA:
undetectable
1nw5A-3o8lA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 THR A 669
PHE A 675
SER A 222
VAL A 218
ALA A 418
None
1.05A 1nw5A-3o8lA:
undetectable
1nw5A-3o8lA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_1
(ASPARTYLPROTEASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 11 GLY A 224
ALA A 225
ASP A 226
VAL A 207
ILE A 261
PO4  A 767 ( 4.6A)
None
None
None
None
0.86A 1ohrA-3o8lA:
undetectable
1ohrA-3o8lA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 TYR A  55
LEU A 348
VAL A 335
PHE A 169
VAL A 352
ATP  A 763 (-4.5A)
None
None
None
None
1.13A 1q23B-3o8lA:
undetectable
1q23B-3o8lA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 TYR A  55
LEU A 348
VAL A 335
PHE A 169
VAL A 352
ATP  A 763 (-4.5A)
None
None
None
None
1.15A 1q23C-3o8lA:
undetectable
1q23C-3o8lA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 10 TYR A  55
LEU A 348
VAL A 335
PHE A 169
VAL A 352
ATP  A 763 (-4.5A)
None
None
None
None
1.12A 1q23E-3o8lA:
undetectable
1q23E-3o8lA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 11 TYR A  55
LEU A 348
VAL A 335
PHE A 169
VAL A 352
ATP  A 763 (-4.5A)
None
None
None
None
1.12A 1q23F-3o8lA:
undetectable
1q23F-3o8lA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 TYR A  55
LEU A 348
VAL A 335
PHE A 169
VAL A 352
ATP  A 763 (-4.5A)
None
None
None
None
1.13A 1q23H-3o8lA:
undetectable
1q23I-3o8lA:
undetectable
1q23H-3o8lA:
15.81
1q23I-3o8lA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 11 TYR A  55
LEU A 348
VAL A 335
PHE A 169
VAL A 352
ATP  A 763 (-4.5A)
None
None
None
None
1.16A 1q23I-3o8lA:
undetectable
1q23I-3o8lA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 11 TYR A  55
LEU A 348
VAL A 335
PHE A 169
VAL A 352
ATP  A 763 (-4.5A)
None
None
None
None
1.11A 1q23J-3o8lA:
undetectable
1q23J-3o8lA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 10 TYR A  55
LEU A 348
VAL A 335
PHE A 169
VAL A 352
ATP  A 763 (-4.5A)
None
None
None
None
1.16A 1q23K-3o8lA:
undetectable
1q23K-3o8lA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 11 TYR A  55
LEU A 348
VAL A 335
PHE A 169
VAL A 352
ATP  A 763 (-4.5A)
None
None
None
None
1.13A 1q23L-3o8lA:
undetectable
1q23L-3o8lA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 ARG A 310
ASN A 547
LEU A 546
ASP A 554
LEU A 626
None
0.93A 1r9oA-3o8lA:
undetectable
1r9oA-3o8lA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
4 / 8 ALA A 125
LEU A 122
GLY A 120
GLY A  24
None
None
ATP  A 763 (-2.9A)
ATP  A 763 (-3.3A)
0.85A 1rukH-3o8lA:
undetectable
1rukL-3o8lA:
undetectable
1rukH-3o8lA:
16.22
1rukL-3o8lA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_2
(PROTEASE RETROPEPSIN)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 GLY A 224
ALA A 225
ASP A 226
ILE A 192
VAL A 207
PO4  A 767 ( 4.6A)
None
None
None
None
0.95A 1sdtB-3o8lA:
undetectable
1sdtB-3o8lA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_2
(PROTEASE RETROPEPSIN)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 GLY A 224
ALA A 225
ASP A 226
VAL A 207
ILE A 261
PO4  A 767 ( 4.6A)
None
None
None
None
0.76A 1sdtB-3o8lA:
undetectable
1sdtB-3o8lA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_2
(PROTEASE RETROPEPSIN)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 GLY A 224
ALA A 225
ASP A 226
ILE A 192
VAL A 207
PO4  A 767 ( 4.6A)
None
None
None
None
1.06A 1sduB-3o8lA:
undetectable
1sduB-3o8lA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 9 GLY A  54
SER A  23
LEU A  21
PHE A  92
LEU A 113
None
ATP  A 763 (-3.2A)
None
None
None
1.44A 1y7iA-3o8lA:
2.8
1y7iA-3o8lA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_1
(HIV-1 PROTEASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 10 GLY A 224
ALA A 225
ASP A 226
ILE A 192
VAL A 207
PO4  A 767 ( 4.6A)
None
None
None
None
0.99A 2aquA-3o8lA:
undetectable
2aquA-3o8lA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_1
(HIV-1 PROTEASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 10 GLY A 224
ALA A 225
ASP A 226
VAL A 207
ILE A 261
PO4  A 767 ( 4.6A)
None
None
None
None
0.81A 2aquA-3o8lA:
undetectable
2aquA-3o8lA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_2
(HIV-1 PROTEASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
6 / 11 GLY A 224
ALA A 225
ASP A 226
ILE A 192
VAL A 207
ILE A 261
PO4  A 767 ( 4.6A)
None
None
None
None
None
1.03A 2aquB-3o8lA:
undetectable
2aquB-3o8lA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_2
(POL POLYPROTEIN)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 GLY A 224
ALA A 225
ASP A 226
VAL A 207
ILE A 261
PO4  A 767 ( 4.6A)
None
None
None
None
0.82A 2avoB-3o8lA:
undetectable
2avoB-3o8lA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_3
(POL POLYPROTEIN)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
6 / 12 GLY A 224
ALA A 225
ASP A 226
ILE A 192
VAL A 207
ILE A 261
PO4  A 767 ( 4.6A)
None
None
None
None
None
1.03A 2avvB-3o8lA:
undetectable
2avvB-3o8lA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_2
(POL POLYPROTEIN)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 GLY A 224
ALA A 225
ILE A 192
VAL A 207
ILE A 261
PO4  A 767 ( 4.6A)
None
None
None
None
0.96A 2f81B-3o8lA:
undetectable
2f81B-3o8lA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_1
(POL PROTEIN)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
6 / 12 GLY A 224
ALA A 225
ASP A 226
ILE A 192
VAL A 207
ILE A 261
PO4  A 767 ( 4.6A)
None
None
None
None
None
1.05A 2fxeA-3o8lA:
undetectable
2fxeA-3o8lA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
6 / 12 GLY A 414
THR A 544
THR A 528
ALA A 527
ARG A 420
ALA A 676
None
None
PO4  A 768 (-4.5A)
None
PO4  A 767 (-4.4A)
None
1.31A 2gluB-3o8lA:
undetectable
2gluB-3o8lA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 ILE A 260
ILE A 259
ALA A 225
ALA A 216
LEU A 296
None
1.01A 2h79A-3o8lA:
undetectable
2h79A-3o8lA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_2
(PROTEASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 GLY A 224
ALA A 225
ILE A 192
VAL A 207
ILE A 261
PO4  A 767 ( 4.6A)
None
None
None
None
0.98A 2ienB-3o8lA:
undetectable
2ienB-3o8lA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_1
(PROTEASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 LEU A  58
ALA A 125
GLY A 118
GLY A 117
ILE A 116
None
None
ATP  A 763 (-2.9A)
ATP  A 763 ( 4.5A)
None
0.96A 2o4kA-3o8lA:
undetectable
2o4kA-3o8lA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_2
(PROTEASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 GLY A 224
ALA A 225
ASP A 226
VAL A 207
ILE A 261
PO4  A 767 ( 4.6A)
None
None
None
None
0.87A 2o4lB-3o8lA:
undetectable
2o4lB-3o8lA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
4 / 4 SER A 164
GLY A 163
HIS A 183
ASP A 672
None
1.33A 2oxtC-3o8lA:
undetectable
2oxtC-3o8lA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
6 / 12 GLY A 163
ALA A 181
GLN A  28
GLN A 300
GLY A  29
ASP A 309
None
1.47A 2pkkA-3o8lA:
3.9
2pkkA-3o8lA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_1
(PROTEASE RETROPEPSIN)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 GLY A 224
ALA A 225
ASP A 226
VAL A 207
ILE A 261
PO4  A 767 ( 4.6A)
None
None
None
None
0.96A 2pymA-3o8lA:
undetectable
2pymA-3o8lA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_1
(PROTEASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 9 ALA A 225
ASP A 226
ILE A 192
VAL A 207
ILE A 261
None
0.99A 2q5kA-3o8lA:
undetectable
2q5kA-3o8lA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_2
(PROTEASE RETROPEPSIN)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 GLY A 224
ALA A 225
ASP A 226
ILE A 192
VAL A 207
PO4  A 767 ( 4.6A)
None
None
None
None
0.99A 2qhcB-3o8lA:
undetectable
2qhcB-3o8lA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_2
(PROTEASE RETROPEPSIN)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 GLY A 224
ALA A 225
ASP A 226
VAL A 207
ILE A 261
PO4  A 767 ( 4.6A)
None
None
None
None
0.94A 2qhcB-3o8lA:
undetectable
2qhcB-3o8lA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
3 / 3 LEU A 434
ASN A 489
ARG A 432
None
0.95A 2qhfA-3o8lA:
undetectable
2qhfA-3o8lA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
3 / 3 LYS A 466
ARG A 420
VAL A 419
None
PO4  A 767 (-4.4A)
None
0.67A 2r2vC-3o8lA:
undetectable
2r2vD-3o8lA:
undetectable
2r2vC-3o8lA:
3.78
2r2vD-3o8lA:
3.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_2
(PROTEASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 GLY A 224
ALA A 225
ASP A 226
VAL A 207
ILE A 261
PO4  A 767 ( 4.6A)
None
None
None
None
0.87A 2r5pB-3o8lA:
undetectable
2r5pB-3o8lA:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_2
(PROTEASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 GLY A 224
ALA A 225
ASP A 226
VAL A 207
ILE A 261
PO4  A 767 ( 4.6A)
None
None
None
None
0.87A 2r5pD-3o8lA:
undetectable
2r5pD-3o8lA:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_2
(PROTEASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
6 / 11 GLY A 224
ALA A 225
ASP A 226
ILE A 260
ILE A 192
VAL A 207
PO4  A 767 ( 4.6A)
None
None
None
None
None
1.38A 2r5qB-3o8lA:
undetectable
2r5qB-3o8lA:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 9 LEU A 136
LEU A 156
LEU A 105
ALA A 101
PHE A 128
None
1.24A 2vcvD-3o8lA:
undetectable
2vcvD-3o8lA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 9 LEU A 136
LEU A 156
LEU A 105
ALA A 101
PHE A 128
None
1.22A 2vcvE-3o8lA:
undetectable
2vcvE-3o8lA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 9 LEU A 136
LEU A 156
LEU A 105
ALA A 101
PHE A 128
None
1.21A 2vcvH-3o8lA:
undetectable
2vcvH-3o8lA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_0
(NON-STRUCTURAL
PROTEIN 5)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 GLY A  61
LEU A  58
GLU A  53
ASP A  63
ILE A  65
None
0.94A 2wa2B-3o8lA:
undetectable
2wa2B-3o8lA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_1
(HIV-1 PROTEASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 GLY A 224
ALA A 225
ASP A 226
ILE A 192
VAL A 207
PO4  A 767 ( 4.6A)
None
None
None
None
1.04A 2z54A-3o8lA:
undetectable
2z54A-3o8lA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_2
(HIV-1 PROTEASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
6 / 12 GLY A 224
ALA A 225
ASP A 226
ILE A 192
VAL A 207
ILE A 261
PO4  A 767 ( 4.6A)
None
None
None
None
None
1.09A 2z54B-3o8lA:
undetectable
2z54B-3o8lA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
4 / 4 LEU A 546
ARG A 746
LEU A 586
ALA A 581
None
1.15A 3b9mA-3o8lA:
undetectable
3b9mA-3o8lA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_2
(PROTEASE
(RETROPEPSIN))
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
6 / 12 GLY A 224
ALA A 225
ASP A 226
ILE A 192
VAL A 207
ILE A 261
PO4  A 767 ( 4.6A)
None
None
None
None
None
1.11A 3bvbB-3o8lA:
undetectable
3bvbB-3o8lA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
4 / 4 VAL A  48
ARG A  35
ILE A 116
THR A  44
None
PO4  A 766 (-4.4A)
None
None
1.22A 3cl9A-3o8lA:
undetectable
3cl9A-3o8lA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_1
(HIV-1 PROTEASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 GLY A 224
ALA A 225
ASP A 226
VAL A 207
ILE A 261
PO4  A 767 ( 4.6A)
None
None
None
None
0.98A 3cyxA-3o8lA:
undetectable
3cyxA-3o8lA:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_2
(HIV-1 PROTEASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 GLY A 224
ALA A 225
ILE A 192
VAL A 207
ILE A 261
PO4  A 767 ( 4.6A)
None
None
None
None
0.95A 3d20B-3o8lA:
undetectable
3d20B-3o8lA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 11 LEU A 324
ALA A 320
ALA A  46
VAL A  48
LYS A  16
None
1.31A 3e22B-3o8lA:
undetectable
3e22B-3o8lA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_1
(PROTEASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 10 GLY A 224
ALA A 225
ASP A 226
VAL A 207
ILE A 261
PO4  A 767 ( 4.6A)
None
None
None
None
0.81A 3ekyA-3o8lA:
undetectable
3ekyA-3o8lA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_2
(PROTEASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 GLY A 224
ALA A 225
ASP A 226
VAL A 207
ILE A 261
PO4  A 767 ( 4.6A)
None
None
None
None
0.81A 3el1B-3o8lA:
undetectable
3el1B-3o8lA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_1
(PROTEASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 11 GLY A 224
ALA A 225
ASP A 226
VAL A 207
ILE A 261
PO4  A 767 ( 4.6A)
None
None
None
None
0.80A 3em4A-3o8lA:
undetectable
3em4A-3o8lA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_1
(PROTEASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 11 GLY A 224
ALA A 225
ASP A 226
VAL A 207
ILE A 261
PO4  A 767 ( 4.6A)
None
None
None
None
0.78A 3em4U-3o8lA:
undetectable
3em4U-3o8lA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
4 / 7 GLY A 163
GLY A 118
THR A  22
ALA A  27
None
ATP  A 763 (-2.9A)
None
None
0.78A 3fpjB-3o8lA:
2.0
3fpjB-3o8lA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 SER A 121
GLY A 117
GLY A  85
GLY A  54
GLY A  24
ATP  A 763 (-2.4A)
ATP  A 763 ( 4.5A)
None
None
ATP  A 763 (-3.3A)
0.89A 3gczA-3o8lA:
undetectable
3gczA-3o8lA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 ILE A 260
ILE A 259
ALA A 225
ALA A 216
LEU A 296
None
0.98A 3gwsX-3o8lA:
undetectable
3gwsX-3o8lA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 GLY A 117
GLY A  29
LEU A 312
SER A 306
ALA A  27
ATP  A 763 ( 4.5A)
None
None
None
None
1.03A 3kkzB-3o8lA:
undetectable
3kkzB-3o8lA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
4 / 6 TYR A 635
ASN A 608
LEU A 605
ASP A 604
None
1.49A 3lslG-3o8lA:
undetectable
3lslG-3o8lA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_1
(HIV-1 PROTEASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 GLY A 224
ALA A 225
ASP A 226
VAL A 207
ILE A 261
PO4  A 767 ( 4.6A)
None
None
None
None
0.95A 3lzsA-3o8lA:
undetectable
3lzsA-3o8lA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_2
(HIV-1 PROTEASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
6 / 12 GLY A 224
ALA A 225
ASP A 226
ILE A 192
VAL A 207
ILE A 261
PO4  A 767 ( 4.6A)
None
None
None
None
None
1.19A 3lzuB-3o8lA:
undetectable
3lzuB-3o8lA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_2
(PROTEASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 11 GLY A 224
ALA A 225
ASP A 226
VAL A 207
ILE A 261
PO4  A 767 ( 4.6A)
None
None
None
None
0.82A 3ndxB-3o8lA:
undetectable
3ndxB-3o8lA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_2
(PROTEASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 10 GLY A 224
ALA A 225
ILE A 192
VAL A 207
ILE A 261
PO4  A 767 ( 4.6A)
None
None
None
None
0.90A 3nu6B-3o8lA:
undetectable
3nu6B-3o8lA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_2
(PROTEASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 GLY A 224
ALA A 225
ILE A 192
VAL A 207
ILE A 261
PO4  A 767 ( 4.6A)
None
None
None
None
0.90A 3pwmB-3o8lA:
undetectable
3pwmB-3o8lA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_1
(PROTEASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 GLY A 224
ALA A 225
ASP A 226
ILE A 192
VAL A 207
PO4  A 767 ( 4.6A)
None
None
None
None
0.98A 3tkgA-3o8lA:
undetectable
3tkgA-3o8lA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_1
(PROTEASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 GLY A 224
ALA A 225
ASP A 226
ILE A 192
VAL A 207
PO4  A 767 ( 4.6A)
None
None
None
None
0.93A 3tkgC-3o8lA:
undetectable
3tkgC-3o8lA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 TYR A  55
LEU A 348
VAL A 335
PHE A 169
VAL A 352
ATP  A 763 (-4.5A)
None
None
None
None
1.12A 3u9fB-3o8lA:
undetectable
3u9fC-3o8lA:
undetectable
3u9fB-3o8lA:
15.81
3u9fC-3o8lA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 10 TYR A  55
LEU A 348
VAL A 335
PHE A 169
VAL A 352
ATP  A 763 (-4.5A)
None
None
None
None
1.05A 3u9fE-3o8lA:
undetectable
3u9fE-3o8lA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 10 TYR A  55
LEU A 348
VAL A 335
PHE A 169
VAL A 352
ATP  A 763 (-4.5A)
None
None
None
None
1.04A 3u9fI-3o8lA:
undetectable
3u9fI-3o8lA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 TYR A  55
LEU A 348
VAL A 335
PHE A 169
VAL A 352
ATP  A 763 (-4.5A)
None
None
None
None
1.15A 3u9fJ-3o8lA:
undetectable
3u9fK-3o8lA:
undetectable
3u9fJ-3o8lA:
15.81
3u9fK-3o8lA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 11 TYR A  55
LEU A 348
VAL A 335
PHE A 169
VAL A 352
ATP  A 763 (-4.5A)
None
None
None
None
1.02A 3u9fN-3o8lA:
undetectable
3u9fO-3o8lA:
undetectable
3u9fN-3o8lA:
15.81
3u9fO-3o8lA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_P_CLMP221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 9 TYR A  55
LEU A 348
VAL A 335
PHE A 169
VAL A 352
ATP  A 763 (-4.5A)
None
None
None
None
1.04A 3u9fP-3o8lA:
undetectable
3u9fP-3o8lA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 10 TYR A  55
LEU A 348
VAL A 335
PHE A 169
VAL A 352
ATP  A 763 (-4.5A)
None
None
None
None
1.06A 3u9fR-3o8lA:
undetectable
3u9fR-3o8lA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 TYR A  55
LEU A 348
VAL A 335
PHE A 169
VAL A 352
ATP  A 763 (-4.5A)
None
None
None
None
1.10A 3u9fP-3o8lA:
undetectable
3u9fS-3o8lA:
undetectable
3u9fP-3o8lA:
15.81
3u9fS-3o8lA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
4 / 7 ILE A 259
GLU A 206
THR A 294
VAL A 279
None
0.81A 3ua5B-3o8lA:
undetectable
3ua5B-3o8lA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_C_SVRC516_1
(RNA-DEPENDENT RNA
POLYMERASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 9 PRO A 526
GLY A 497
ALA A 527
ALA A 413
ASP A 672
None
1.46A 3ur0C-3o8lA:
undetectable
3ur0C-3o8lA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_2
(ASPARTYL PROTEASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
6 / 10 GLY A 224
ALA A 225
ASP A 226
ILE A 192
VAL A 207
ILE A 261
PO4  A 767 ( 4.6A)
None
None
None
None
None
1.04A 4dqfB-3o8lA:
undetectable
4dqfB-3o8lA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
4 / 5 SER A 276
GLY A 278
VAL A 283
ASP A 281
None
1.04A 4eohA-3o8lA:
3.3
4eohA-3o8lA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_1
(PROTEASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 GLY A 224
ALA A 225
ASP A 226
VAL A 207
ILE A 261
PO4  A 767 ( 4.6A)
None
None
None
None
0.95A 4hlaA-3o8lA:
undetectable
4hlaA-3o8lA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_2
(PROTEASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 11 GLY A 224
ALA A 225
ASP A 226
VAL A 207
ILE A 261
PO4  A 767 ( 4.6A)
None
None
None
None
0.95A 4hlaB-3o8lA:
undetectable
4hlaB-3o8lA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 VAL A  34
GLY A 163
SER A 314
GLY A 317
THR A  22
None
1.09A 4mm8A-3o8lA:
undetectable
4mm8A-3o8lA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
4 / 5 ASN A  31
GLY A  80
ASP A 168
ASP A  26
None
None
ATP  A 763 ( 4.7A)
None
1.15A 4n48B-3o8lA:
undetectable
4n48B-3o8lA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
4 / 4 ASN A  31
GLY A  80
ASP A 168
ASP A  26
None
None
ATP  A 763 ( 4.7A)
None
1.18A 4n49A-3o8lA:
undetectable
4n49A-3o8lA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_2
(ASPARTYL PROTEASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 LEU A 711
ILE A 496
ILE A 425
VAL A 523
ILE A 525
None
0.80A 4q1xB-3o8lA:
undetectable
4q1xB-3o8lA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 9 ALA A 542
ILE A 496
ASP A 672
GLY A 414
ALA A 413
None
1.25A 4r1zA-3o8lA:
undetectable
4r1zA-3o8lA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 9 ALA A 542
ILE A 525
ASP A 672
GLY A 414
ALA A 413
None
1.22A 4r1zA-3o8lA:
undetectable
4r1zA-3o8lA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 5 ILE A 116
VAL A  20
ILE A  84
VAL A  34
THR A  82
None
1.48A 4xdtA-3o8lA:
undetectable
4xdtA-3o8lA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 10 LEU A 586
LEU A 749
GLY A 585
ALA A  36
ILE A 748
None
1.12A 4xj7C-3o8lA:
4.9
4xj7D-3o8lA:
5.6
4xj7C-3o8lA:
17.52
4xj7D-3o8lA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
4 / 7 SER A 276
ASP A 290
ARG A 201
THR A 195
None
0.91A 5btaA-3o8lA:
undetectable
5btaC-3o8lA:
undetectable
5btaD-3o8lA:
2.3
5btaA-3o8lA:
23.09
5btaC-3o8lA:
23.09
5btaD-3o8lA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
4 / 7 SER A 276
ASP A 290
ARG A 201
THR A 195
None
0.83A 5btfA-3o8lA:
undetectable
5btfB-3o8lA:
3.2
5btfC-3o8lA:
undetectable
5btfA-3o8lA:
23.09
5btfB-3o8lA:
16.08
5btfC-3o8lA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_A_SAMA301_0
(NS5
METHYLTRANSFERASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 SER A 121
GLY A 117
GLY A  85
GLY A  54
GLY A  24
ATP  A 763 (-2.4A)
ATP  A 763 ( 4.5A)
None
None
ATP  A 763 (-3.3A)
0.92A 5ekxA-3o8lA:
undetectable
5ekxA-3o8lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 ALA A 683
THR A 704
PHE A 720
GLY A 708
THR A 724
None
1.38A 5hfjG-3o8lA:
undetectable
5hfjG-3o8lA:
15.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 ALA A 683
THR A 704
PHE A 720
GLY A 708
THR A 724
None
1.36A 5hfjH-3o8lA:
2.2
5hfjH-3o8lA:
15.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
3 / 3 ALA A 101
ASN A 104
LEU A 105
None
0.48A 5i1oA-3o8lA:
undetectable
5i1oA-3o8lA:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 GLY A 660
VAL A 529
THR A 528
ALA A 581
LEU A 580
None
None
PO4  A 768 (-4.5A)
None
None
1.06A 5kocA-3o8lA:
undetectable
5kocA-3o8lA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_1
(PROTEASE E35D-SQV)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 GLY A 224
ALA A 225
ASP A 226
VAL A 207
ILE A 261
PO4  A 767 ( 4.6A)
None
None
None
None
0.88A 5kqxA-3o8lA:
undetectable
5kqxA-3o8lA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 10 LEU A 711
ALA A 676
ILE A 425
VAL A 523
ILE A 525
None
0.82A 5kr1A-3o8lA:
undetectable
5kr1A-3o8lA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 ILE A  18
VAL A 159
ILE A  42
ALA A  46
VAL A  38
None
1.13A 5n0sB-3o8lA:
4.2
5n0sB-3o8lA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 VAL A 159
VAL A 115
ILE A  42
ALA A  46
VAL A  38
None
1.17A 5n0sB-3o8lA:
4.2
5n0sB-3o8lA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 ILE A 496
PHE A 671
GLY A 680
LEU A 718
PHE A 538
None
ADP  A 764 (-3.8A)
None
None
ADP  A 764 (-4.0A)
1.35A 5v5zA-3o8lA:
undetectable
5v5zA-3o8lA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
4 / 5 VAL A 204
LEU A 247
CYH A 244
ASP A 281
None
1.23A 5vcvA-3o8lA:
undetectable
5vcvA-3o8lA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
3 / 3 HIS A 734
GLU A 597
ASN A 628
None
1.00A 5wbvA-3o8lA:
undetectable
5wbvA-3o8lA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
3 / 3 HIS A 734
GLU A 597
ASN A 628
None
0.99A 5wbvB-3o8lA:
undetectable
5wbvB-3o8lA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 10 VAL A 115
GLY A 160
ALA A 125
LEU A 113
ASN A 157
None
1.17A 5x6yB-3o8lA:
undetectable
5x6yB-3o8lA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
3 / 3 ARG A 424
ARG A 246
ARG A 253
PO4  A 767 (-2.9A)
ATP  A 765 (-3.6A)
None
0.81A 6bplA-3o8lA:
undetectable
6bplB-3o8lA:
undetectable
6bplA-3o8lA:
7.16
6bplB-3o8lA:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_1
(HIV-1 PROTEASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
6 / 12 GLY A 224
ALA A 225
ASP A 226
ILE A 260
ILE A 192
VAL A 207
PO4  A 767 ( 4.6A)
None
None
None
None
None
1.22A 6dj1B-3o8lA:
undetectable
6dj1B-3o8lA:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_1
(HIV-1 PROTEASE)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
6 / 12 GLY A 224
ALA A 225
ASP A 226
ILE A 260
ILE A 192
VAL A 207
PO4  A 767 ( 4.6A)
None
None
None
None
None
1.21A 6dj2B-3o8lA:
undetectable
6dj2B-3o8lA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
4 / 5 LEU A 711
ILE A 485
MET A 684
GLY A 680
None
0.89A 6hd6A-3o8lA:
undetectable
6hd6A-3o8lA:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus)
5 / 12 THR A 582
ILE A 595
TYR A 594
ALA A 607
LEU A 749
None
1.28A 6ie8A-3o8lA:
undetectable
6ie8A-3o8lA:
12.40