SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o8o'

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1AGM_A_ACRA496_2 (GLUCOAMYLASE-471)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	4 / 5	SER A 390 TRP A 653 GLU A 651 LEU A 620	None	1.40A	1agmA-3o8oA: undetectable	1agmA-3o8oA: 21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1E7B_A_HLTA4002_1 (SERUM ALBUMIN)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	4 / 4	ARG B 946 ALA B 769 ALA B 823 GLU B 786	None	1.03A	1e7bA-3o8oB: undetectable	1e7bA-3o8oB: 22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1E7B_B_HLTB4002_1 (SERUM ALBUMIN)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	4 / 4	ARG B 946 ALA B 769 ALA B 823 GLU B 786	None	1.09A	1e7bB-3o8oB: undetectable	1e7bB-3o8oB: 22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1E7C_A_HLTA4002_1 (SERUM ALBUMIN)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	4 / 5	ARG B 946 ALA B 769 ALA B 823 GLU B 786	None	1.01A	1e7cA-3o8oB: undetectable	1e7cA-3o8oB: 22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FB7_A_ROCA100_1 (HIV-1 PROTEASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	5 / 12	GLY A 414 ALA A 415 ASP A 416 VAL A 397 ILE A 452	None	0.93A	1fb7A-3o8oA: undetectable	1fb7A-3o8oA: 8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FBM_B_RTLB951_2 (PROTEIN (CARTILAGE OLIGOMERIC MATRIX PROTEIN))	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	4 / 4	THR B 497 LEU B 501 VAL B 504 LEU B 508	None	0.71A	1fbmD-3o8oB: undetectable	1fbmD-3o8oB: 5.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FBM_B_RTLB951_3 (PROTEIN (CARTILAGE OLIGOMERIC MATRIX PROTEIN))	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	4 / 5	THR B 497 LEU B 501 VAL B 504 LEU B 508	None	0.87A	1fbmE-3o8oB: undetectable	1fbmE-3o8oB: 5.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HSG_B_MK1B902_2 (HIV-1 PROTEASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	5 / 12	GLY A 414 ALA A 415 ASP A 416 VAL A 397 ILE A 452	None	0.99A	1hsgB-3o8oA: undetectable	1hsgB-3o8oA: 8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HSH_A_MK1A401_1 (HIV-II PROTEASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	5 / 12	GLY A 414 ALA A 415 ASP A 416 ILE A 375 ILE A 452	None	0.85A	1hshA-3o8oA: undetectable	1hshA-3o8oA: 7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HSH_C_MK1C402_1 (HIV-II PROTEASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	5 / 12	GLY A 414 ALA A 415 ASP A 416 ILE A 375 ILE A 452	None	0.87A	1hshC-3o8oA: undetectable	1hshC-3o8oA: 7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JR1_B_MOAB1333_1 (INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE 2)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA 6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	4 / 8	ASP A 356 GLY A 492 THR B 377 GLY A 215	F6P  A 988 (-2.8A) None None F6P  A 988 ( 4.8A)	0.87A	1jr1B-3o8oA: undetectable	1jr1B-3o8oA: 21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MUI_B_AB1B100_2 (PROTEASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	6 / 12	GLY A 414 ALA A 415 ASP A 416 ILE A 382 VAL A 397 ILE A 452	None	1.23A	1muiB-3o8oA: undetectable	1muiB-3o8oA: 8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1N5X_A_TEIA3006_1 (XANTHINE DEHYDROGENASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	5 / 12	LEU B 681 LEU B 696 SER B 692 THR B 660 ALA B 664	None	1.17A	1n5xA-3o8oB: 0.2	1n5xA-3o8oB: 21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1N5X_B_TEIB4006_1 (XANTHINE DEHYDROGENASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	5 / 12	LEU B 681 LEU B 696 SER B 692 THR B 660 ALA B 664	None	1.17A	1n5xB-3o8oB: 1.0	1n5xB-3o8oB: 21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NBH_A_SAMA293_1 (GLYCINE N-METHYLTRANSFERASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	3 / 3	ARG B 867 ASP B 492 ASN B 214	None	0.93A	1nbhA-3o8oB: 2.9	1nbhA-3o8oB: 17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NBH_D_SAMD3293_1 (GLYCINE N-METHYLTRANSFERASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	3 / 3	ARG B 867 ASP B 492 ASN B 214	None	0.90A	1nbhD-3o8oB: undetectable	1nbhD-3o8oB: 17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1R9O_A_FLPA501_1 (CYTOCHROME P450 2C9)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	5 / 12	ARG B 493 ASN B 735 LEU B 734 ASP B 742 LEU B 818	None	1.01A	1r9oA-3o8oB: undetectable	1r9oA-3o8oB: 20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RJD_C_SAMC803_0 (CARBOXY METHYL TRANSFERASE FOR PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	5 / 12	ASP A 499 ALA A 495 GLY A 353 GLY A 367 SER A 364	None	1.08A	1rjdC-3o8oA: undetectable	1rjdC-3o8oA: 16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RUK_H_BEZH601_0 (IMMUNOGLOBULIN IGG2A, HEAVY CHAIN IMMUNOGLOBULIN IGG2A, LIGHT CHAIN)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	4 / 8	ALA A 315 LEU A 312 GLY A 310 GLY A 214	None	0.84A	1rukH-3o8oA: undetectable 1rukL-3o8oA: undetectable	1rukH-3o8oA: 13.98 1rukL-3o8oA: 15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1S1U_A_NVPA999_1 (REVERSE TRANSCRIPTASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	5 / 10	ILE B 412 VAL B 444 TYR B 409 GLY B 402 LEU B 565	None	1.13A	1s1uA-3o8oB: undetectable	1s1uA-3o8oB: 21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UWH_A_BAXA1723_2 (B-RAF PROTO-ONCOGENE SERINE/THREONINE-PRO TEIN KINASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	4 / 6	VAL A 548 VAL A 397 ILE A 355 ILE A 375	None None F6P  A 988 (-4.9A) None	0.80A	1uwhA-3o8oA: undetectable	1uwhA-3o8oA: 16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UWH_A_BAXA1723_2 (B-RAF PROTO-ONCOGENE SERINE/THREONINE-PRO TEIN KINASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	4 / 6	VAL B 541 VAL B 389 ILE B 347 ILE B 367	None	0.83A	1uwhA-3o8oB: undetectable	1uwhA-3o8oB: 17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1VIF_A_FOLA1_0 (DIHYDROFOLATE REDUCTASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	3 / 3	GLN B 425 ILE B 429 TYR B 409	None	0.60A	1vifA-3o8oB: undetectable	1vifA-3o8oB: 6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1VQ1_B_SAMB301_0 (N5-GLUTAMINE METHYLTRANSFERASE, HEMK)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	5 / 12	THR B 268 ILE B 358 GLY B 345 GLY B 300 SER B 303	None	0.98A	1vq1B-3o8oB: undetectable	1vq1B-3o8oB: 17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOQ_A_ROFA502_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA 6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	3 / 3	ASN A 609 TRP A 653 GLN B 746	None	1.31A	1xoqA-3o8oA: undetectable	1xoqA-3o8oA: 18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Z9H_A_IMNA379_1 (MEMBRANE-ASSOCIATED PROSTAGLANDIN E SYNTHASE-2)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	5 / 12	VAL A 470 TYR A 417 ILE A 418 VAL A 425 LEU A 434	None	1.44A	1z9hA-3o8oA: undetectable	1z9hA-3o8oA: 16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Z9H_C_IMNC379_1 (MEMBRANE-ASSOCIATED PROSTAGLANDIN E SYNTHASE-2)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	5 / 12	VAL A 470 TYR A 417 ILE A 418 VAL A 425 LEU A 434	None	1.44A	1z9hC-3o8oA: undetectable	1z9hC-3o8oA: 16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ZQ9_A_SAMA4000_1 (PROBABLE DIMETHYLADENOSINE TRANSFERASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	3 / 3	GLY A 768 GLU A 827 ASN A 726	FDP  A   1 (-3.7A) FDP  A   1 (-2.8A) FDP  A   1 (-3.7A)	0.61A	1zq9A-3o8oA: undetectable	1zq9A-3o8oA: 16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AQU_B_DR7B300_1 (HIV-1 PROTEASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	5 / 10	GLY A 414 ALA A 415 ASP A 416 VAL A 397 ILE A 452	None	0.88A	2aquA-3o8oA: undetectable	2aquA-3o8oA: 8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AQU_B_DR7B300_2 (HIV-1 PROTEASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	6 / 11	GLY A 414 ALA A 415 ASP A 416 ILE A 382 VAL A 397 ILE A 452	None	1.19A	2aquB-3o8oA: undetectable	2aquB-3o8oA: 8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AVV_A_MK1A901_3 (POL POLYPROTEIN)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	6 / 12	GLY A 414 ALA A 415 ASP A 416 ILE A 382 VAL A 397 ILE A 452	None	1.15A	2avvB-3o8oA: undetectable	2avvB-3o8oA: 8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2B25_B_SAMB602_0 (HYPOTHETICAL PROTEIN)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	5 / 12	GLY B 345 SER B 346 GLY B 359 VAL B 297 ILE B 218	None F6P  B 980 ( 4.4A) None None None	1.12A	2b25B-3o8oB: undetectable	2b25B-3o8oB: 18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BXP_A_P1ZA3001_1 (SERUM ALBUMIN)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	5 / 12	LEU A 571 LEU A 407 ALA A 406 ILE A 418 ALA A 412	None	1.11A	2bxpA-3o8oA: undetectable	2bxpA-3o8oA: 22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2FXE_A_DR7A102_1 (POL PROTEIN)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	6 / 12	GLY A 414 ALA A 415 ASP A 416 ILE A 382 VAL A 397 ILE A 452	None	1.17A	2fxeA-3o8oA: undetectable	2fxeA-3o8oA: 7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HYY_B_STIB600_2 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	4 / 6	LEU B 587 VAL B 594 VAL B 711 ILE B 591	None	1.11A	2hyyB-3o8oB: undetectable	2hyyB-3o8oB: 17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OXT_C_SAMC300_1 (NUCLEOSIDE-2'-O-METH YLTRANSFERASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA 6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	4 / 4	SER A 370 GLY A 367 HIS A 488 ASP B 473	None None F6P  A 988 (-4.2A) None	1.26A	2oxtC-3o8oA: undetectable	2oxtC-3o8oA: 15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PO5_B_CHDB502_0 (FERROCHELATASE, MITOCHONDRIAL)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	4 / 8	LEU B 397 ARG B 392 VAL B 344 GLY B 345	None F6P  B 980 (-3.8A) None None	0.97A	2po5B-3o8oB: 4.9	2po5B-3o8oB: 18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QHF_A_ACTA502_0 (CHORISMATE SYNTHASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	3 / 3	GLY B 599 ASP B 864 SER B 603	None	0.65A	2qhfA-3o8oB: undetectable	2qhfA-3o8oB: 22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2R5P_D_MK1D902_2 (PROTEASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	6 / 12	GLY A 414 ALA A 415 ASP A 416 ILE A 382 VAL A 397 ILE A 452	None	1.21A	2r5pD-3o8oA: undetectable	2r5pD-3o8oA: 8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2RLF_A_RIMA199_1 (MATRIX PROTEIN 2)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	4 / 6	LEU B 734 LEU B 737 ILE B 494 ARG B 493	None	0.78A	2rlfA-3o8oB: undetectable 2rlfB-3o8oB: undetectable	2rlfA-3o8oB: 5.11 2rlfB-3o8oB: 5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2RLF_B_RIMB299_1 (MATRIX PROTEIN 2)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	4 / 6	LEU B 734 LEU B 737 ILE B 494 ARG B 493	None	0.70A	2rlfB-3o8oB: undetectable 2rlfC-3o8oB: undetectable	2rlfB-3o8oB: 5.11 2rlfC-3o8oB: 5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2RLF_C_RIMC399_1 (MATRIX PROTEIN 2)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	4 / 6	LEU B 734 LEU B 737 ILE B 494 ARG B 493	None	0.92A	2rlfC-3o8oB: undetectable 2rlfD-3o8oB: undetectable	2rlfC-3o8oB: 5.11 2rlfD-3o8oB: 5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ROX_B_T44B128_1 (TRANSTHYRETIN)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	4 / 6	LEU A 837 GLU A 844 ALA A 839 THR A 854	None	1.11A	2roxB-3o8oA: undetectable	2roxB-3o8oA: 11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2TSR_A_D16A309_1 (THYMIDYLATE SYNTHASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA 6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	4 / 7	ARG B 383 ILE A 355 ASP A 309 GLY A 308	F6P  A 988 (-2.3A) F6P  A 988 (-4.9A) None None	0.77A	2tsrA-3o8oB: undetectable	2tsrA-3o8oB: 18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V3K_A_SAMA1254_0 (ESSENTIAL FOR MITOTIC GROWTH 1)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	5 / 10	LEU B 287 VAL B 292 GLY B 291 GLY B 283 LEU B 239	None	0.84A	2v3kA-3o8oB: undetectable	2v3kA-3o8oB: 15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VAV_F_CSCF1383_2 (ACETYL-COA--DEACETYL CEPHALOSPORIN C ACETYLTRANSFERASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	3 / 3	LEU B 565 MET B 569 MET B 871	None	0.96A	2vavF-3o8oB: 2.4	2vavF-3o8oB: 20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VCT_C_ASDC1223_1 (GLUTATHIONE S-TRANSFERASE A2)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	4 / 8	GLY A 729 LEU A 718 PHE A 696 PHE A 693	None	0.89A	2vctC-3o8oA: undetectable	2vctC-3o8oA: 15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XCT_H_CPFH1020_1 (DNA GYRASE SUBUNIT B, DNA GYRASE SUBUNIT A)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	3 / 3	ARG A 564 GLU A 422 SER A 868	None	0.91A	2xctD-3o8oA: undetectable	2xctD-3o8oA: 22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YOE_C_FL7C1318_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	4 / 8	GLY A 265 ILE A 366 VAL A 508 SER A 268	None	0.92A	2yoeB-3o8oA: undetectable 2yoeC-3o8oA: undetectable	2yoeB-3o8oA: 15.91 2yoeC-3o8oA: 15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Z54_A_AB1A200_1 (HIV-1 PROTEASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	5 / 12	GLY A 414 ALA A 415 ASP A 416 VAL A 397 ILE A 452	None	0.93A	2z54A-3o8oA: undetectable	2z54A-3o8oA: 8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Z54_A_AB1A200_2 (HIV-1 PROTEASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	6 / 12	GLY A 414 ALA A 415 ASP A 416 ILE A 382 VAL A 397 ILE A 452	None	1.18A	2z54B-3o8oA: undetectable	2z54B-3o8oA: 8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AQI_B_CHDB4_0 (FERROCHELATASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	4 / 6	ARG B 636 PRO B 661 GLY B 625 TRP B 626	None	1.49A	3aqiB-3o8oB: 3.0	3aqiB-3o8oB: 19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BJW_B_SVRB501_2 (PHOSPHOLIPASE A2)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	5 / 11	VAL A 352 LEU A 351 GLY A 350 ILE A 348 SER A 523	None	1.14A	3bjwB-3o8oA: undetectable	3bjwB-3o8oA: 9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BJW_E_SVRE503_1 (PHOSPHOLIPASE A2)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	5 / 11	VAL A 352 LEU A 351 GLY A 350 ILE A 348 SER A 523	None	1.23A	3bjwE-3o8oA: undetectable	3bjwE-3o8oA: 9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BJW_F_SVRF502_3 (PHOSPHOLIPASE A2)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	5 / 12	VAL A 352 LEU A 351 GLY A 350 ILE A 348 PRO A 537	None	1.16A	3bjwF-3o8oA: undetectable	3bjwF-3o8oA: 9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BJW_H_SVRH504_3 (PHOSPHOLIPASE A2)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	5 / 11	VAL A 352 LEU A 351 GLY A 350 ILE A 348 SER A 523	None	1.13A	3bjwH-3o8oA: 0.0	3bjwH-3o8oA: 9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D1Z_B_017B201_2 (HIV-1 PROTEASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	5 / 12	GLY A 414 ALA A 415 ASP A 416 ILE A 382 ILE A 452	None	1.07A	3d1zB-3o8oA: undetectable	3d1zB-3o8oA: 8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EKY_A_DR7A100_1 (PROTEASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	5 / 10	GLY A 414 ALA A 415 ASP A 416 VAL A 397 ILE A 452	None	0.92A	3ekyA-3o8oA: undetectable	3ekyA-3o8oA: 9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EL1_A_DR7A100_1 (PROTEASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	5 / 11	GLY A 414 ALA A 415 ASP A 416 VAL A 397 ILE A 452	None	0.89A	3el1A-3o8oA: undetectable	3el1A-3o8oA: 8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ELZ_B_CHDB200_0 (ILEAL BILE ACID-BINDING PROTEIN)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	4 / 5	PRO B 459 VAL B 462 THR B 405 GLY B 402	None	1.06A	3elzB-3o8oB: undetectable	3elzB-3o8oB: 10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EM0_B_CHDB151_0 (ILEAL BILE ACID-BINDING PROTEIN)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	5 / 12	CYH B 341 ILE B 340 VAL B 504 GLY B 500 LEU B 304	None	1.08A	3em0B-3o8oB: undetectable	3em0B-3o8oB: 10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EM4_A_DR7A100_1 (PROTEASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	5 / 11	GLY A 414 ALA A 415 ASP A 416 VAL A 397 ILE A 452	None	0.84A	3em4A-3o8oA: undetectable	3em4A-3o8oA: 9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EM4_V_DR7V100_1 (PROTEASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	5 / 11	GLY A 414 ALA A 415 ASP A 416 VAL A 397 ILE A 452	None	0.87A	3em4U-3o8oA: undetectable	3em4U-3o8oA: 9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3F8W_B_ADNB301_1 (PURINE-NUCLEOSIDE PHOSPHORYLASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	5 / 12	SER A 733 GLY A 695 VAL A 601 GLY A 602 VAL A 727	None	1.40A	3f8wB-3o8oA: undetectable	3f8wB-3o8oA: 16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FHX_B_PXLB313_1 (PYRIDOXAL KINASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	4 / 8	VAL A 453 VAL A 425 TYR A 417 VAL A 394	None	0.90A	3fhxB-3o8oA: undetectable	3fhxB-3o8oA: 17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3G88_A_SAMA303_0 (RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE G)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	5 / 11	GLY B 205 GLY B 300 ALA B 269 GLU B 234 ALA B 208	None	1.10A	3g88A-3o8oB: undetectable	3g88A-3o8oB: 16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3G88_B_SAMB303_0 (RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE G)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	5 / 11	GLY B 205 GLY B 300 ALA B 269 GLU B 234 ALA B 208	None	1.11A	3g88B-3o8oB: 2.1	3g88B-3o8oB: 16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3G89_B_SAMB303_0 (RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE G)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	5 / 11	GLY B 205 GLY B 300 ALA B 269 GLU B 234 ALA B 208	None	1.10A	3g89B-3o8oB: undetectable	3g89B-3o8oB: 16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3G8B_B_SAMB303_0 (RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE G)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	5 / 12	GLY B 205 GLY B 300 ALA B 269 GLU B 234 ALA B 208	None	1.07A	3g8bB-3o8oB: undetectable	3g8bB-3o8oB: 16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3H52_A_486A3_1 (GLUCOCORTICOID RECEPTOR)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	5 / 12	MET A 536 LEU A 525 GLY A 350 VAL A 304 LEU A 502	None	1.36A	3h52A-3o8oA: undetectable	3h52A-3o8oA: 14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HEG_A_BAXA1_2 (MITOGEN-ACTIVATED PROTEIN KINASE 14)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	4 / 6	VAL B 757 ILE B 788 ILE B 817 LEU B 818	None	0.80A	3hegA-3o8oB: undetectable	3hegA-3o8oB: 18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K2H_B_LYAB514_2 (DIHYDROFOLATE REDUCTASE/THYMIDYLAT E SYNTHASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	3 / 3	ARG A 613 THR A 663 THR A 738	None	0.69A	3k2hB-3o8oA: undetectable	3k2hB-3o8oA: 21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K5V_B_STIB2_2 (TYROSINE-PROTEIN KINASE ABL1)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	4 / 6	LEU B 587 VAL B 594 VAL B 711 ILE B 591	None	1.08A	3k5vB-3o8oB: undetectable	3k5vB-3o8oB: 18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LZU_A_017A200_2 (HIV-1 PROTEASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	6 / 12	GLY A 414 ALA A 415 ASP A 416 ILE A 382 VAL A 397 ILE A 452	None	1.29A	3lzuB-3o8oA: undetectable	3lzuB-3o8oA: 8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3M6W_A_SAMA465_0 (RRNA METHYLASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA 6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 12	GLY B 729 VAL B 854 ASP A 749 PRO B 851 VAL B 743	None	0.91A	3m6wA-3o8oB: undetectable	3m6wA-3o8oB: 19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MDT_B_VORB506_1 (CHOLESTEROL 24-HYDROXYLASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	5 / 11	TYR B 767 LEU B 768 SER B 718 ALA B 598 ALA B 736	None None FDP  B   2 (-2.5A) None None	1.10A	3mdtB-3o8oB: undetectable	3mdtB-3o8oB: 20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NDW_A_RITA100_1 (PROTEASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	5 / 12	GLY A 414 ALA A 415 ASP A 416 VAL A 397 ILE A 452	None	0.91A	3ndwA-3o8oA: undetectable	3ndwA-3o8oA: 8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NDX_A_RITA100_1 (PROTEASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	5 / 12	GLY A 414 ALA A 415 ASP A 416 VAL A 397 ILE A 452	None	0.89A	3ndxA-3o8oA: undetectable	3ndxA-3o8oA: 8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q5S_A_ACHA1289_0 (MULTIDRUG-EFFLUX TRANSPORTER 1 REGULATOR)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA 6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	4 / 6	VAL A 860 TYR A 746 TYR B 740 ILE A 856	None	1.02A	3q5sA-3o8oA: undetectable	3q5sA-3o8oA: 16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ROD_A_NCAA302_0 (NICOTINAMIDE N-METHYLTRANSFERASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	4 / 8	ASP B 950 ALA B 949 SER B 773 SER B 781	None	0.95A	3rodA-3o8oB: undetectable	3rodA-3o8oB: 17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3S79_A_ASDA601_1 (CYTOCHROME P450 19A1)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	5 / 12	ILE A 452 ILE A 420 ALA A 454 VAL A 470 LEU A 474	None	1.21A	3s79A-3o8oA: undetectable	3s79A-3o8oA: 20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SOA_A_DB8A445_1 (CALCIUM/CALMODULIN-D EPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA WITH A BETA 7 LINKER)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	4 / 6	LEU A 255 VAL A 241 MET A 211 PHE A 282	None	1.06A	3soaA-3o8oA: undetectable	3soaA-3o8oA: 20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SOA_A_DB8A445_1 (CALCIUM/CALMODULIN-D EPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA WITH A BETA 7 LINKER)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	4 / 6	LEU A 255 VAL A 241 MET A 211 PHE A 318	None	1.08A	3soaA-3o8oA: undetectable	3soaA-3o8oA: 20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UQB_A_FK5A114_1 (UBIQUITIN-LIKE PROTEIN SMT3, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	4 / 8	PHE A 679 VAL A 599 ILE A 598 ILE A 882	None	0.85A	3uqbA-3o8oA: undetectable	3uqbA-3o8oA: 13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V3O_B_T1CB405_1 (TETX2 PROTEIN)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	5 / 12	ARG B 366 GLY B 480 ALA B 360 GLY B 359 ASN B 349	None	1.24A	3v3oB-3o8oB: 2.5	3v3oB-3o8oB: 18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WIP_G_ACTG305_0 (ACETYLCHOLINE-BINDIN G PROTEIN)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	3 / 3	ASP B 679 ARG B 618 LYS B 588	None	1.11A	3wipG-3o8oB: undetectable	3wipG-3o8oB: 14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A6E_A_SAMA1349_1 (HYDROXYINDOLE O-METHYLTRANSFERASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA 6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	3 / 3	TYR A 381 ASP B 365 ASP B 372	None	0.88A	4a6eA-3o8oA: undetectable	4a6eA-3o8oA: 18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BUP_B_SAMB500_1 (HISTONE-LYSINE N-METHYLTRANSFERASE SUV420H1)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	3 / 3	HIS A 654 GLU A 651 ASN A 448	None	0.99A	4bupB-3o8oA: undetectable	4bupB-3o8oA: 16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4C9K_B_CAMB424_0 (CYTOCHROME P450)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	5 / 9	LEU A 740 LEU A 743 THR A 782 VAL A 787 VAL A 824	None	1.19A	4c9kB-3o8oA: undetectable	4c9kB-3o8oA: 20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4CTK_C_SAMC1263_0 (POLYPROTEIN)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	5 / 12	SER B 213 GLY B 486 GLY B 262 GLY B 210 GLU B 261	None	0.81A	4ctkC-3o8oB: undetectable	4ctkC-3o8oB: 15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DJF_B_C2FB300_0 (5-METHYLTETRAHYDROFO LATE CORRINOID/IRON SULFUR PROTEIN METHYLTRANSFERASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	5 / 12	GLU B 414 PHE B 561 ASP B 350 ASP B 348 GLY B 448	None None None F6P  B 980 (-3.0A) None	1.41A	4djfB-3o8oB: undetectable	4djfB-3o8oB: 16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DX7_B_DM2B1104_1 (ACRIFLAVINE RESISTANCE PROTEIN B)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	4 / 8	SER B 614 GLN B 615 ILE B 682 VAL B 711	None	0.99A	4dx7B-3o8oB: undetectable	4dx7B-3o8oB: 21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EM2_A_SALA503_1 (UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	4 / 6	LYS A 700 ILE A 939 VAL A 926 LEU A 718	None	1.10A	4em2A-3o8oA: undetectable	4em2A-3o8oA: 10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FEU_B_KANB301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	4 / 7	ASN B 524 GLU B 725 ASP B 355 GLU B 560	None	1.17A	4feuB-3o8oB: undetectable	4feuB-3o8oB: 17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FEU_F_KANF301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	4 / 8	ASN B 524 GLU B 725 ASP B 355 GLU B 560	None	1.15A	4feuF-3o8oB: undetectable	4feuF-3o8oB: 17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FEV_D_KAND301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	4 / 7	ASN B 524 GLU B 725 ASP B 355 GLU B 560	None	1.15A	4fevD-3o8oB: undetectable	4fevD-3o8oB: 17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FEV_F_KANF301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	4 / 7	ASN B 524 GLU B 725 ASP B 355 GLU B 560	None	1.14A	4fevF-3o8oB: undetectable	4fevF-3o8oB: 17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FEW_B_KANB301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	4 / 7	ASN B 524 GLU B 725 ASP B 355 GLU B 560	None	1.17A	4fewB-3o8oB: undetectable	4fewB-3o8oB: 17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FEW_D_KAND301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	4 / 8	ASN B 524 GLU B 725 ASP B 355 GLU B 560	None	1.17A	4fewD-3o8oB: undetectable	4fewD-3o8oB: 17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FEW_F_KANF301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	4 / 8	ASN B 524 GLU B 725 ASP B 355 GLU B 560	None	1.17A	4fewF-3o8oB: undetectable	4fewF-3o8oB: 17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FO4_A_MOAA502_1 (INOSINE 5'-MONOPHOSPHATE DEHYDROGENASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	5 / 8	SER B 259 SER B 213 ASN B 212 CYH B 298 GLY B 500	None	1.35A	4fo4A-3o8oB: undetectable	4fo4A-3o8oB: 21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FOR_A_FLPA711_1 (LACTOTRANSFERRIN)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	4 / 7	GLY A 632 VAL A 599 ASN A 664 GLY A 692	None	0.87A	4forA-3o8oA: undetectable	4forA-3o8oA: 18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4GKH_F_KANF301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	4 / 8	ASN B 524 GLU B 725 ASP B 355 GLU B 560	None	1.15A	4gkhF-3o8oB: undetectable	4gkhF-3o8oB: 17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4GKH_G_KANG301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	4 / 7	ASN B 524 GLU B 725 ASP B 355 GLU B 560	None	1.17A	4gkhG-3o8oB: undetectable	4gkhG-3o8oB: 17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4GKI_A_KANA301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	4 / 8	ASN B 524 GLU B 725 ASP B 355 GLU B 560	None	1.17A	4gkiA-3o8oB: undetectable	4gkiA-3o8oB: 17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4GKI_G_KANG301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	4 / 8	ASN B 524 GLU B 725 ASP B 355 GLU B 560	None	1.14A	4gkiE-3o8oB: undetectable 4gkiG-3o8oB: undetectable	4gkiE-3o8oB: 17.86 4gkiG-3o8oB: 17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KMU_C_RFPC1401_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	5 / 12	HIS B 481 ARG B 484 LEU B 397 PRO B 209 ILE B 347	F6P  B 980 (-4.1A) F6P  B 980 (-3.4A) None None None	1.33A	4kmuC-3o8oB: undetectable	4kmuC-3o8oB: 21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KTT_A_SAMA405_1 (S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	4 / 8	ASP A 840 ILE A 842 ASP A 802 ILE A 799	None	0.91A	4kttB-3o8oA: undetectable	4kttB-3o8oA: 21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L1W_A_STRA402_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	4 / 7	VAL B 215 ILE B 218 LEU B 287 LEU B 295	None	1.04A	4l1wA-3o8oB: undetectable	4l1wA-3o8oB: 18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LXZ_A_SHHA407_1 (HISTONE DEACETYLASE 2)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	5 / 12	PRO B 709 ASP B 679 HIS B 617 ASP B 881 GLY B 877	None	1.13A	4lxzA-3o8oB: undetectable	4lxzA-3o8oB: 17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LXZ_B_SHHB408_1 (HISTONE DEACETYLASE 2)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	5 / 11	PRO B 709 ASP B 679 HIS B 617 ASP B 881 GLY B 877	None	1.12A	4lxzB-3o8oB: undetectable	4lxzB-3o8oB: 17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LXZ_C_SHHC406_1 (HISTONE DEACETYLASE 2)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	5 / 12	PRO B 709 ASP B 679 HIS B 617 ASP B 881 GLY B 877	None	1.09A	4lxzC-3o8oB: undetectable	4lxzC-3o8oB: 17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4M83_B_ERYB501_0 (OLEANDOMYCIN GLYCOSYLTRANSFERASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	5 / 11	TRP B 626 ASN B 593 VAL B 684 ILE B 589 ALA B 875	None	1.48A	4m83B-3o8oB: undetectable	4m83B-3o8oB: 20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NNR_A_FK5A201_1 (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP2)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	5 / 12	PHE A 679 VAL A 599 ILE A 598 ILE A 882 PRO A 720	None	1.26A	4nnrA-3o8oA: undetectable 4nnrB-3o8oA: undetectable	4nnrA-3o8oA: 11.92 4nnrB-3o8oA: 11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OBW_C_SAMC601_0 (2-METHOXY-6-POLYPREN YL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA 6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 12	GLY A 864 ASP B 742 ASN A 655 GLY A 735 ASN A 609	None	1.24A	4obwC-3o8oA: undetectable	4obwC-3o8oA: 14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVY_B_BO2B201_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-1)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	5 / 11	HIS A 498 THR A 504 SER A 268 ALA A 495 THR A 494	None	1.36A	4qvyV-3o8oA: undetectable 4qvyb-3o8oA: undetectable	4qvyV-3o8oA: 16.13 4qvyb-3o8oA: 13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVY_N_BO2N201_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-1)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	5 / 11	HIS A 498 THR A 504 SER A 268 ALA A 495 THR A 494	None	1.36A	4qvyH-3o8oA: undetectable 4qvyN-3o8oA: 0.0	4qvyH-3o8oA: 16.13 4qvyN-3o8oA: 13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QWU_K_BO2K301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	5 / 9	ALA A 223 ALA A 222 GLY A 307 GLY A 353 ASP A 499	None	1.11A	4qwuK-3o8oA: undetectable 4qwuL-3o8oA: undetectable	4qwuK-3o8oA: 14.58 4qwuL-3o8oA: 16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QWU_Y_BO2Y301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	5 / 9	ALA A 223 ALA A 222 GLY A 307 GLY A 353 ASP A 499	None	1.15A	4qwuY-3o8oA: undetectable 4qwuZ-3o8oA: undetectable	4qwuY-3o8oA: 14.58 4qwuZ-3o8oA: 16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4U15_B_0HKB1201_1 (MUSCARINIC ACETYLCHOLINE RECEPTOR M3,LYSOZYME,MUSCARIN IC ACETYLCHOLINE RECEPTOR M3)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	5 / 12	ASP A 737 SER A 867 ALA A 611 ALA A 610 TYR A 732	None	1.41A	4u15B-3o8oA: undetectable	4u15B-3o8oA: 20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XP1_A_LDPA708_1 (DOPAMINE TRANSPORTER, ISOFORM B)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	5 / 10	ASP A 870 VAL A 929 TYR A 732 PHE A 877 SER A 733	None	1.29A	4xp1A-3o8oA: undetectable	4xp1A-3o8oA: 21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YJI_A_TYLA502_1 (ARYL ACYLAMIDASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	4 / 7	SER B 727 GLY B 686 GLY B 685 ILE B 601	None	0.61A	4yjiA-3o8oB: undetectable	4yjiA-3o8oB: 22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5B2Q_A_ACTA1728_0 (CRISPR-ASSOCIATED ENDONUCLEASE CAS9)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	3 / 3	ASN A 574 SER A 875 ARG A 613	None	0.94A	5b2qA-3o8oA: undetectable	5b2qA-3o8oA: 18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CXV_A_0HKA501_1 (MUSCARINIC ACETYLCHOLINE RECEPTOR M1,ENDOLYSIN,MUSCARI NIC ACETYLCHOLINE RECEPTOR M1)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	5 / 12	ASP A 737 SER A 867 ALA A 611 ALA A 610 TYR A 732	None	1.38A	5cxvA-3o8oA: undetectable	5cxvA-3o8oA: 20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ESJ_A_TPFA602_1 (LANOSTEROL 14-ALPHA DEMETHYLASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	4 / 8	ILE B 410 PHE B 561 GLY B 395 MET B 554	None	0.91A	5esjA-3o8oB: undetectable	5esjA-3o8oB: 21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ESK_A_1YNA701_1 (LANOSTEROL 14-ALPHA DEMETHYLASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	5 / 12	GLY A 493 LEU A 405 ILE A 420 GLY A 410 THR A 413	None	1.17A	5eskA-3o8oA: undetectable	5eskA-3o8oA: 22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5F9Z_A_HFGA702_0 (AMINOACYL-TRNA SYNTHETASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	5 / 12	LEU A 743 GLY A 858 GLU A 827 VAL A 766 GLY A 602	None None FDP  A   1 (-2.8A) None None	1.31A	5f9zA-3o8oA: 2.4	5f9zA-3o8oA: 20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HFJ_F_SAMF301_0 (ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA))	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	5 / 12	ALA B 446 THR B 866 GLN B 647 GLY B 402 SER B 406	None	1.25A	5hfjF-3o8oB: undetectable	5hfjF-3o8oB: 13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5I1O_H_DVAH9_0 (D-VILLIN HEADPIECE SUBDOMAIN VILLIN-1)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	3 / 3	ALA A 291 ASN A 294 LEU A 295	None	0.46A	5i1oA-3o8oA: undetectable	5i1oA-3o8oA: 4.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5J4N_A_AG2A501_1 (ARGININE/AGMATINE ANTIPORTER)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	4 / 6	SER A 659 GLY A 632 ASN A 631 ILE A 598	None	0.96A	5j4nA-3o8oA: undetectable	5j4nA-3o8oA: 21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JKV_A_ASDA602_1 (AROMATASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	5 / 12	ILE A 452 ILE A 420 ALA A 454 VAL A 470 LEU A 474	None	1.21A	5jkvA-3o8oA: undetectable	5jkvA-3o8oA: 20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JSD_B_1GNB603_1 (PHIAB6 TAILSPIKE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	3 / 3	VAL B 910 GLU B 560 GLU B 563	None	0.90A	5jsdB-3o8oB: undetectable 5jsdC-3o8oB: undetectable	5jsdB-3o8oB: 22.34 5jsdC-3o8oB: 22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L5F_B_BO2B201_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-1)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	5 / 11	HIS A 498 THR A 504 SER A 268 ALA A 495 THR A 494	None	1.34A	5l5fV-3o8oA: undetectable 5l5fb-3o8oA: undetectable	5l5fV-3o8oA: 16.13 5l5fb-3o8oA: 13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L5F_N_BO2N201_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-1)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	5 / 11	HIS A 498 THR A 504 SER A 268 ALA A 495 THR A 494	None	1.35A	5l5fH-3o8oA: undetectable 5l5fN-3o8oA: 0.0	5l5fH-3o8oA: 16.13 5l5fN-3o8oA: 13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L5Z_B_BO2B201_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-1)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA 6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	5 / 12	HIS A 389 SER A 388 THR B 203 SER B 213 GLY B 210	None	1.33A	5l5zV-3o8oA: undetectable 5l5zb-3o8oA: undetectable	5l5zV-3o8oA: 16.13 5l5zb-3o8oA: 13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L5Z_N_BO2N201_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-1)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA 6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	5 / 12	HIS A 389 SER A 388 THR B 203 SER B 213 GLY B 210	None	1.33A	5l5zH-3o8oA: undetectable 5l5zN-3o8oA: undetectable	5l5zH-3o8oA: 16.13 5l5zN-3o8oA: 13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LF7_H_6V8H305_0 (PROTEASOME SUBUNIT BETA TYPE-3 PROTEASOME SUBUNIT BETA TYPE-7)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	5 / 11	ALA A 721 ALA A 603 GLY A 602 THR A 663 LEU A 687	None FDP  A   1 ( 3.8A) None None None	0.88A	5lf7H-3o8oA: undetectable 5lf7I-3o8oA: undetectable	5lf7H-3o8oA: 17.33 5lf7I-3o8oA: 13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LF7_H_6V8H305_0 (PROTEASOME SUBUNIT BETA TYPE-3 PROTEASOME SUBUNIT BETA TYPE-7)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	5 / 11	ALA B 715 ALA B 596 GLY B 595 THR B 656 LEU B 681	None FDP  B   2 (-3.5A) None None None	0.98A	5lf7H-3o8oB: undetectable 5lf7I-3o8oB: undetectable	5lf7H-3o8oB: 16.60 5lf7I-3o8oB: 15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LF7_V_6V8V303_0 (PROTEASOME SUBUNIT BETA TYPE-3 PROTEASOME SUBUNIT BETA TYPE-7)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	5 / 11	ALA A 721 ALA A 603 GLY A 602 THR A 663 LEU A 687	None FDP  A   1 ( 3.8A) None None None	0.89A	5lf7V-3o8oA: undetectable 5lf7W-3o8oA: undetectable	5lf7V-3o8oA: 17.33 5lf7W-3o8oA: 13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LF7_V_6V8V303_0 (PROTEASOME SUBUNIT BETA TYPE-3 PROTEASOME SUBUNIT BETA TYPE-7)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	5 / 11	ALA B 715 ALA B 596 GLY B 595 THR B 656 LEU B 681	None FDP  B   2 (-3.5A) None None None	0.96A	5lf7V-3o8oB: undetectable 5lf7W-3o8oB: undetectable	5lf7V-3o8oB: 16.60 5lf7W-3o8oB: 15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M50_E_TA1E502_1 (TUBULIN BETA-2B CHAIN)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	5 / 12	ASP A 363 GLU A 567 LEU A 740 HIS A 498 GLY A 931	None	1.33A	5m50E-3o8oA: 3.4	5m50E-3o8oA: 20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VC0_A_RITA602_1 (CYTOCHROME P450 3A4)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	5 / 12	ARG B 586 ILE B 682 ALA B 872 ILE B 571 ALA B 574	None	1.09A	5vc0A-3o8oB: undetectable	5vc0A-3o8oB: 20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VKQ_B_PCFB1806_0 (NO MECHANORECEPTOR POTENTIAL C ISOFORM L)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	4 / 6	ILE A 366 ILE A 348 LEU A 538 PHE A 318	None	0.96A	5vkqB-3o8oA: undetectable 5vkqC-3o8oA: undetectable	5vkqB-3o8oA: 19.52 5vkqC-3o8oA: 19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VKQ_B_PCFB1806_0 (NO MECHANORECEPTOR POTENTIAL C ISOFORM L)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	4 / 6	ILE B 358 ILE B 340 LEU B 531 PHE B 310	None	0.95A	5vkqB-3o8oB: undetectable 5vkqC-3o8oB: undetectable	5vkqB-3o8oB: 19.21 5vkqC-3o8oB: 19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VKQ_C_PCFC1807_0 (NO MECHANORECEPTOR POTENTIAL C ISOFORM L)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	4 / 6	ILE B 358 ILE B 340 LEU B 531 PHE B 310	None	0.99A	5vkqC-3o8oB: undetectable 5vkqD-3o8oB: undetectable	5vkqC-3o8oB: 19.21 5vkqD-3o8oB: 19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5W7B_B_PA1B204_1 (ACYLOXYACYL HYDROLASE SMALL SUBUNIT ACYLOXYACYL HYDROLASE LARGE SUBUNIT)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA 6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	3 / 3	GLY A 658 ASN A 609 ARG B 812	None	0.68A	5w7bD-3o8oA: undetectable	5w7bD-3o8oA: 7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIW_B_LOCB504_2 (TUBULIN BETA CHAIN)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	5 / 12	LEU B 818 LEU B 734 ALA B 775 ALA B 778 ILE B 494	None	1.01A	5xiwB-3o8oB: undetectable	5xiwB-3o8oB: 7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZV2_A_LEVA801_2 (FIBROBLAST GROWTH FACTOR RECEPTOR 1)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	3 / 3	LYS A 792 LEU A 838 ASP A 802	None	0.94A	5zv2A-3o8oA: undetectable	5zv2A-3o8oA: 7.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CJK_C_ACTC301_0 (IMMUNOGLOBULIN FAB LIGHT CHAIN)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	4 / 4	VAL A 352 GLY A 308 ASP A 309 ASP A 356	None None None F6P  A 988 (-2.8A)	1.16A	6cjkC-3o8oA: undetectable	6cjkC-3o8oA: 14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CNJ_D_NCTD402_1 (NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4 NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	4 / 8	TYR A 369 THR A 873 TRP A 404 LEU A 571	None	1.30A	6cnjD-3o8oA: undetectable 6cnjE-3o8oA: undetectable	6cnjD-3o8oA: 7.26 6cnjE-3o8oA: 10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJ1_B_AB1B201_1 (HIV-1 PROTEASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	6 / 12	GLY A 414 ALA A 415 ASP A 416 ILE A 451 ILE A 382 VAL A 397	None	1.30A	6dj1B-3o8oA: undetectable	6dj1B-3o8oA: 8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJ2_B_AB1B201_1 (HIV-1 PROTEASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	6 / 12	GLY A 414 ALA A 415 ASP A 416 ILE A 451 ILE A 382 VAL A 397	None	1.29A	6dj2B-3o8oA: undetectable	6dj2B-3o8oA: 8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6E5Z_A_CCSA106_0 (PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	5 / 10	GLY B 599 GLY B 600 ASN B 602 PRO B 597 GLY B 858	None	1.07A	6e5zA-3o8oB: 4.2	6e5zA-3o8oB: 14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FGD_A_ACTA821_0 (GEPHYRIN)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	3 / 3	ARG B 752 PHE B 813 GLY B 809	None	0.81A	6fgdA-3o8oB: 2.6	6fgdA-3o8oB: 21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GNF_A_QPSA602_1 (-)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA 6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	5 / 12	PHE A 762 ASN B 602 GLN B 856 PRO B 597 GLY B 599	None None FDP  B   2 (-3.6A) None None	1.22A	6gnfA-3o8oA: undetectable	6gnfA-3o8oA: 21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MKE_A_FK5A201_0 (PEPTIDYLPROLYL ISOMERASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	5 / 12	PHE A 679 VAL A 599 ILE A 598 ILE A 882 ILE A 939	None	1.15A	6mkeA-3o8oA: undetectable 6mkeD-3o8oA: undetectable	6mkeA-3o8oA: 7.46 6mkeD-3o8oA: 7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MKE_B_FK5B201_0 (PEPTIDYLPROLYL ISOMERASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	5 / 12	PHE A 679 VAL A 599 ILE A 598 ILE A 882 ILE A 939	None	1.25A	6mkeB-3o8oA: undetectable 6mkeC-3o8oA: undetectable	6mkeB-3o8oA: 7.46 6mkeC-3o8oA: 7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6NCS_A_ACTA303_0 (N-ACETYLNEURAMINIC ACID (SIALIC ACID) SYNTHETASE)	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT BETA (Saccharomyces cerevisiae)	3 / 3	ILE B 476 THR B 477 PRO B 459	None	0.33A	6ncsA-3o8oB: undetectable	6ncsA-3o8oB: 16.23