SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o98'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E6W_C_ESTC302_1
(SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 4 ALA A  24
GLN A 148
TYR A  26
LEU A  69
 None
 1.30A 1e6wC-3o98A:
3.2		 1e6wC-3o98A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2R_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.20A 1k2rA-3o98A:
undetectable
1k2rB-3o98A:
undetectable		 1k2rA-3o98A:
21.04
1k2rB-3o98A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2S_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.20A 1k2sA-3o98A:
undetectable
1k2sB-3o98A:
undetectable		 1k2sA-3o98A:
21.04
1k2sB-3o98A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LZX_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.18A 1lzxA-3o98A:
undetectable
1lzxB-3o98A:
undetectable		 1lzxA-3o98A:
21.04
1lzxB-3o98A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LZZ_B_H4BB1760_1
(NITRIC-OXIDE
SYNTHASE)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.17A 1lzzA-3o98A:
undetectable
1lzzB-3o98A:
undetectable		 1lzzA-3o98A:
21.04
1lzzB-3o98A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M00_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.20A 1m00A-3o98A:
undetectable
1m00B-3o98A:
undetectable		 1m00A-3o98A:
21.04
1m00B-3o98A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMV_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.19A 1mmvA-3o98A:
undetectable
1mmvB-3o98A:
undetectable		 1mmvA-3o98A:
21.04
1mmvB-3o98A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMW_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.18A 1mmwA-3o98A:
undetectable
1mmwB-3o98A:
undetectable		 1mmwA-3o98A:
21.04
1mmwB-3o98A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMW_B_H4BB2760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.16A 1mmwA-3o98A:
undetectable
1mmwB-3o98A:
undetectable		 1mmwA-3o98A:
21.04
1mmwB-3o98A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OM4_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.18A 1om4A-3o98A:
undetectable
1om4B-3o98A:
undetectable		 1om4A-3o98A:
20.85
1om4B-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OM4_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.16A 1om4A-3o98A:
undetectable
1om4B-3o98A:
undetectable		 1om4A-3o98A:
20.85
1om4B-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6H_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 6 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.20A 1p6hA-3o98A:
undetectable
1p6hB-3o98A:
undetectable		 1p6hA-3o98A:
20.97
1p6hB-3o98A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6I_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.21A 1p6iA-3o98A:
undetectable
1p6iB-3o98A:
undetectable		 1p6iA-3o98A:
20.97
1p6iB-3o98A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.18A 1p6kA-3o98A:
undetectable
1p6kB-3o98A:
undetectable		 1p6kA-3o98A:
21.28
1p6kB-3o98A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.18A 1p6kA-3o98A:
undetectable
1p6kB-3o98A:
undetectable		 1p6kA-3o98A:
21.28
1p6kB-3o98A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		5 / 12 ALA A 336
LEU A 514
MET A 317
GLY A 315
LEU A 270
 None
 1.17A 1qabF-3o98A:
undetectable		 1qabF-3o98A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		3 / 3 GLU A  83
TRP A  82
LYS A 374
 None
 1.40A 1qu2A-3o98A:
undetectable		 1qu2A-3o98A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		3 / 3 ASP A 334
GLU A 392
ARG A 598
 None
 0.78A 1wopA-3o98A:
undetectable		 1wopA-3o98A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		3 / 3 PHE A 319
TYR A 274
TYR A 331
 None
 1.06A 1x70B-3o98A:
undetectable		 1x70B-3o98A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		3 / 3 LEU A  16
HIS A 152
LYS A  10
 None
 1.13A 1y7iA-3o98A:
undetectable		 1y7iA-3o98A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.19A 1zzqA-3o98A:
undetectable
1zzqB-3o98A:
undetectable		 1zzqA-3o98A:
21.23
1zzqB-3o98A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.16A 1zzqA-3o98A:
undetectable
1zzqB-3o98A:
undetectable		 1zzqA-3o98A:
21.23
1zzqB-3o98A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.17A 1zzrA-3o98A:
undetectable
1zzrB-3o98A:
undetectable		 1zzrA-3o98A:
21.23
1zzrB-3o98A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.18A 1zzuA-3o98A:
undetectable
1zzuB-3o98A:
undetectable		 1zzuA-3o98A:
21.23
1zzuB-3o98A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.15A 1zzuA-3o98A:
undetectable
1zzuB-3o98A:
undetectable		 1zzuA-3o98A:
21.23
1zzuB-3o98A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6H_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 8 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.18A 2g6hA-3o98A:
undetectable
2g6hB-3o98A:
undetectable		 2g6hA-3o98A:
20.91
2g6hB-3o98A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6H_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 6 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.16A 2g6hA-3o98A:
undetectable
2g6hB-3o98A:
undetectable		 2g6hA-3o98A:
20.91
2g6hB-3o98A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6K_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.18A 2g6kA-3o98A:
undetectable
2g6kB-3o98A:
undetectable		 2g6kA-3o98A:
20.91
2g6kB-3o98A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6M_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.18A 2g6mA-3o98A:
undetectable
2g6mB-3o98A:
undetectable		 2g6mA-3o98A:
20.91
2g6mB-3o98A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6M_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.16A 2g6mA-3o98A:
undetectable
2g6mB-3o98A:
undetectable		 2g6mA-3o98A:
20.91
2g6mB-3o98A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		3 / 3 LYS A 440
GLY A 496
PRO A 495
 None
 0.88A 2hreB-3o98A:
undetectable		 2hreB-3o98A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		5 / 12 THR A 446
ASP A 387
GLU A 392
LEU A 416
LEU A 475
 None
 1.35A 2zj0C-3o98A:
undetectable		 2zj0C-3o98A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 6 TRP A 298
ASN A 497
ALA A 499
ASP A 292
 None
 1.36A 3aruA-3o98A:
undetectable		 3aruA-3o98A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3M_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.18A 3b3mA-3o98A:
undetectable
3b3mB-3o98A:
undetectable		 3b3mA-3o98A:
20.85
3b3mB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3M_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.15A 3b3mA-3o98A:
undetectable
3b3mB-3o98A:
undetectable		 3b3mA-3o98A:
20.85
3b3mB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		5 / 12 THR A 446
ASP A 387
GLU A 392
LEU A 416
LEU A 475
 None
 1.38A 3ce6B-3o98A:
undetectable		 3ce6B-3o98A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 5 LEU A 501
GLN A 569
THR A 517
LEU A 270
 None
 1.17A 3ce6D-3o98A:
2.2		 3ce6D-3o98A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.16A 3fc5A-3o98A:
undetectable
3fc5B-3o98A:
undetectable		 3fc5A-3o98A:
21.06
3fc5B-3o98A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC5_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.16A 3fc5A-3o98A:
undetectable
3fc5B-3o98A:
undetectable		 3fc5A-3o98A:
21.06
3fc5B-3o98A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGI_A_BEZA284_0
(CATECHOL
1,2-DIOXYGENASE)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		5 / 12 LEU A 419
ASP A 477
VAL A 478
ILE A 464
ARG A 481
 None
 1.36A 3hgiA-3o98A:
undetectable		 3hgiA-3o98A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HSN_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.17A 3hsnA-3o98A:
undetectable
3hsnB-3o98A:
undetectable		 3hsnA-3o98A:
20.85
3hsnB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HSN_B_H4BB1760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.13A 3hsnA-3o98A:
undetectable
3hsnB-3o98A:
undetectable		 3hsnA-3o98A:
20.85
3hsnB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HSO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.16A 3hsoA-3o98A:
undetectable
3hsoB-3o98A:
undetectable		 3hsoA-3o98A:
20.85
3hsoB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HSP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.14A 3hspA-3o98A:
undetectable
3hspB-3o98A:
undetectable		 3hspA-3o98A:
20.85
3hspB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.18A 3jt4A-3o98A:
undetectable
3jt4B-3o98A:
undetectable		 3jt4A-3o98A:
20.85
3jt4B-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.18A 3jt4A-3o98A:
undetectable
3jt4B-3o98A:
undetectable		 3jt4A-3o98A:
20.85
3jt4B-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.18A 3jt5A-3o98A:
undetectable
3jt5B-3o98A:
undetectable		 3jt5A-3o98A:
20.85
3jt5B-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.16A 3jt5A-3o98A:
undetectable
3jt5B-3o98A:
undetectable		 3jt5A-3o98A:
20.85
3jt5B-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT6_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.18A 3jt6A-3o98A:
undetectable
3jt6B-3o98A:
undetectable		 3jt6A-3o98A:
20.85
3jt6B-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT7_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.16A 3jt7A-3o98A:
undetectable
3jt7B-3o98A:
undetectable		 3jt7A-3o98A:
20.85
3jt7B-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT7_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.18A 3jt7A-3o98A:
undetectable
3jt7B-3o98A:
undetectable		 3jt7A-3o98A:
20.85
3jt7B-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT8_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.19A 3jt8A-3o98A:
undetectable
3jt8B-3o98A:
undetectable		 3jt8A-3o98A:
20.85
3jt8B-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT9_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.17A 3jt9A-3o98A:
undetectable
3jt9B-3o98A:
undetectable		 3jt9A-3o98A:
20.85
3jt9B-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT9_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.18A 3jt9A-3o98A:
undetectable
3jt9B-3o98A:
undetectable		 3jt9A-3o98A:
20.85
3jt9B-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JTA_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.18A 3jtaA-3o98A:
undetectable
3jtaB-3o98A:
undetectable		 3jtaA-3o98A:
20.85
3jtaB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX0_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.18A 3jx0A-3o98A:
undetectable
3jx0B-3o98A:
undetectable		 3jx0A-3o98A:
21.16
3jx0B-3o98A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.19A 3jx1A-3o98A:
undetectable
3jx1B-3o98A:
undetectable		 3jx1A-3o98A:
21.16
3jx1B-3o98A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 8 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.18A 3jx1A-3o98A:
undetectable
3jx1B-3o98A:
undetectable		 3jx1A-3o98A:
21.16
3jx1B-3o98A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.20A 3jx2A-3o98A:
undetectable
3jx2B-3o98A:
undetectable		 3jx2A-3o98A:
21.16
3jx2B-3o98A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.21A 3nlpA-3o98A:
undetectable
3nlpB-3o98A:
undetectable		 3nlpA-3o98A:
21.16
3nlpB-3o98A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLV_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.18A 3nlvA-3o98A:
undetectable
3nlvB-3o98A:
undetectable		 3nlvA-3o98A:
20.85
3nlvB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLX_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.18A 3nlxA-3o98A:
undetectable
3nlxB-3o98A:
undetectable		 3nlxA-3o98A:
20.85
3nlxB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLZ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.19A 3nlzA-3o98A:
undetectable
3nlzB-3o98A:
undetectable		 3nlzA-3o98A:
20.85
3nlzB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLZ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.19A 3nlzA-3o98A:
undetectable
3nlzB-3o98A:
undetectable		 3nlzA-3o98A:
20.85
3nlzB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NM0_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.19A 3nm0A-3o98A:
undetectable
3nm0B-3o98A:
undetectable		 3nm0A-3o98A:
20.85
3nm0B-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 6 ALA A 146
ILE A 145
VAL A 150
HIS A 131
 None
None
None
TS5  A 620 (-4.1A)
 1.05A 3nneG-3o98A:
undetectable		 3nneG-3o98A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNZ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.19A 3nnzA-3o98A:
undetectable
3nnzB-3o98A:
undetectable		 3nnzA-3o98A:
20.85
3nnzB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_2
(HIV-1 PROTEASE)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		5 / 10 LEU A 138
ALA A 116
GLY A 187
VAL A 143
ILE A 135
 None
 1.02A 3oxwD-3o98A:
undetectable		 3oxwD-3o98A:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_2
(HIV-1 PROTEASE)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		5 / 11 LEU A 138
ALA A 116
GLY A 187
VAL A 143
ILE A 135
 None
 1.01A 3oxxD-3o98A:
undetectable		 3oxxD-3o98A:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 8 ASP A 544
GLN A 568
PRO A 534
GLN A 563
 None
ADP  A3001 (-4.0A)
None
None
 1.10A 3oyaA-3o98A:
2.3		 3oyaA-3o98A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PNE_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.19A 3pneA-3o98A:
undetectable
3pneB-3o98A:
undetectable		 3pneA-3o98A:
20.85
3pneB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PNF_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.18A 3pnfA-3o98A:
undetectable
3pnfB-3o98A:
undetectable		 3pnfA-3o98A:
20.85
3pnfB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PNF_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.18A 3pnfA-3o98A:
undetectable
3pnfB-3o98A:
undetectable		 3pnfA-3o98A:
20.85
3pnfB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q99_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.18A 3q99A-3o98A:
undetectable
3q99B-3o98A:
undetectable		 3q99A-3o98A:
20.85
3q99B-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q9A_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.18A 3q9aA-3o98A:
undetectable
3q9aB-3o98A:
undetectable		 3q9aA-3o98A:
20.85
3q9aB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q9A_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.18A 3q9aA-3o98A:
undetectable
3q9aB-3o98A:
undetectable		 3q9aA-3o98A:
20.85
3q9aB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 8 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.18A 3rqlA-3o98A:
undetectable
3rqlB-3o98A:
undetectable		 3rqlA-3o98A:
20.85
3rqlB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQM_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.20A 3rqmA-3o98A:
undetectable
3rqmB-3o98A:
undetectable		 3rqmA-3o98A:
20.85
3rqmB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQN_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.20A 3rqnA-3o98A:
undetectable
3rqnB-3o98A:
undetectable		 3rqnA-3o98A:
20.85
3rqnB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUN_A_CCSA165_0
(LYSOZYME)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		3 / 3 ASN A 497
ALA A 536
LYS A 498
 None
None
ADP  A3001 (-2.9A)
 0.84A 3runA-3o98A:
undetectable		 3runA-3o98A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SVQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 6 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.22A 3svqA-3o98A:
undetectable
3svqB-3o98A:
undetectable		 3svqA-3o98A:
20.85
3svqB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SVQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 6 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.21A 3svqA-3o98A:
undetectable
3svqB-3o98A:
undetectable		 3svqA-3o98A:
20.85
3svqB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYM_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.17A 3tymA-3o98A:
undetectable
3tymB-3o98A:
undetectable		 3tymA-3o98A:
20.85
3tymB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA502_1
(CHITINASE)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 5 GLY A 371
TRP A 373
ALA A 406
PHE A 398
 None
 1.21A 3wqwA-3o98A:
undetectable		 3wqwA-3o98A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C39_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.19A 4c39A-3o98A:
undetectable
4c39B-3o98A:
undetectable		 4c39A-3o98A:
20.85
4c39B-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAN_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.18A 4canA-3o98A:
undetectable
4canB-3o98A:
undetectable		 4canA-3o98A:
20.85
4canB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTU_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.17A 4ctuA-3o98A:
undetectable
4ctuB-3o98A:
undetectable		 4ctuA-3o98A:
20.85
4ctuB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTV_A_H4BA1718_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.21A 4ctvA-3o98A:
undetectable
4ctvB-3o98A:
undetectable		 4ctvA-3o98A:
20.85
4ctvB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTV_B_H4BB1720_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.19A 4ctvA-3o98A:
undetectable
4ctvB-3o98A:
undetectable		 4ctvA-3o98A:
20.85
4ctvB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTW_B_H4BB1720_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.17A 4ctwA-3o98A:
undetectable
4ctwB-3o98A:
undetectable		 4ctwA-3o98A:
20.85
4ctwB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTX_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.18A 4ctxA-3o98A:
undetectable
4ctxB-3o98A:
undetectable		 4ctxA-3o98A:
20.85
4ctxB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTX_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.17A 4ctxA-3o98A:
undetectable
4ctxB-3o98A:
undetectable		 4ctxA-3o98A:
20.85
4ctxB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.17A 4cx3A-3o98A:
undetectable
4cx3B-3o98A:
undetectable		 4cx3A-3o98A:
21.16
4cx3B-3o98A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.18A 4cx3A-3o98A:
undetectable
4cx3B-3o98A:
undetectable		 4cx3A-3o98A:
21.16
4cx3B-3o98A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.18A 4cx4A-3o98A:
undetectable
4cx4B-3o98A:
undetectable		 4cx4A-3o98A:
21.16
4cx4B-3o98A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.19A 4cx4A-3o98A:
undetectable
4cx4B-3o98A:
undetectable		 4cx4A-3o98A:
21.16
4cx4B-3o98A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 6 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.20A 4cx6A-3o98A:
undetectable
4cx6B-3o98A:
undetectable		 4cx6A-3o98A:
20.85
4cx6B-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1N_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.17A 4d1nA-3o98A:
undetectable
4d1nB-3o98A:
undetectable		 4d1nA-3o98A:
19.78
4d1nB-3o98A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1N_D_H4BD760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 6 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.16A 4d1nC-3o98A:
undetectable
4d1nD-3o98A:
undetectable		 4d1nC-3o98A:
19.78
4d1nD-3o98A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D2Y_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.18A 4d2yA-3o98A:
undetectable
4d2yB-3o98A:
undetectable		 4d2yA-3o98A:
20.85
4d2yB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D30_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.22A 4d30A-3o98A:
undetectable
4d30B-3o98A:
undetectable		 4d30A-3o98A:
20.85
4d30B-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D3B_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.17A 4d3bA-3o98A:
undetectable
4d3bB-3o98A:
undetectable		 4d3bA-3o98A:
20.85
4d3bB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D3B_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.16A 4d3bA-3o98A:
undetectable
4d3bB-3o98A:
undetectable		 4d3bA-3o98A:
20.85
4d3bB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_1
(ASPARTYL PROTEASE)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		5 / 11 LEU A 138
ALA A 116
GLY A 187
VAL A 143
ILE A 135
 None
 0.98A 4dqeA-3o98A:
undetectable		 4dqeA-3o98A:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 6 ALA A 443
GLY A 496
PRO A 495
VAL A 493
 None
 1.00A 4dubA-3o98A:
undetectable		 4dubA-3o98A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVW_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.19A 4fvwA-3o98A:
undetectable
4fvwB-3o98A:
undetectable		 4fvwA-3o98A:
20.85
4fvwB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVY_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.19A 4fvyA-3o98A:
undetectable
4fvyB-3o98A:
undetectable		 4fvyA-3o98A:
20.85
4fvyB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVY_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.20A 4fvyA-3o98A:
undetectable
4fvyB-3o98A:
undetectable		 4fvyA-3o98A:
20.85
4fvyB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVZ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.17A 4fvzA-3o98A:
undetectable
4fvzB-3o98A:
undetectable		 4fvzA-3o98A:
20.85
4fvzB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FW0_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.17A 4fw0A-3o98A:
undetectable
4fw0B-3o98A:
undetectable		 4fw0A-3o98A:
20.85
4fw0B-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GQE_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.19A 4gqeA-3o98A:
undetectable
4gqeB-3o98A:
undetectable		 4gqeA-3o98A:
20.85
4gqeB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSG_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.16A 4jsgA-3o98A:
undetectable
4jsgB-3o98A:
undetectable		 4jsgA-3o98A:
20.85
4jsgB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5D_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.18A 4k5dA-3o98A:
undetectable
4k5dB-3o98A:
undetectable		 4k5dA-3o98A:
20.85
4k5dB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5E_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.18A 4k5eA-3o98A:
undetectable
4k5eB-3o98A:
undetectable		 4k5eA-3o98A:
20.85
4k5eB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5E_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 6 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.19A 4k5eA-3o98A:
undetectable
4k5eB-3o98A:
undetectable		 4k5eA-3o98A:
20.85
4k5eB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 6 LEU A 614
ASN A 360
MET A 321
LEU A 263
 None
 1.18A 4okbA-3o98A:
undetectable		 4okbA-3o98A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 6 LEU A 614
ASN A 360
MET A 321
LEU A 263
 None
 1.15A 4okxA-3o98A:
undetectable		 4okxA-3o98A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCH_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.19A 4uchA-3o98A:
undetectable
4uchB-3o98A:
undetectable		 4uchA-3o98A:
19.94
4uchB-3o98A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH2_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 6 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.18A 4uh2A-3o98A:
undetectable
4uh2B-3o98A:
undetectable		 4uh2A-3o98A:
20.85
4uh2B-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH5_A_H4BA760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.14A 4uh5A-3o98A:
undetectable
4uh5B-3o98A:
undetectable		 4uh5A-3o98A:
20.06
4uh5B-3o98A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.18A 4uh6A-3o98A:
undetectable
4uh6B-3o98A:
undetectable		 4uh6A-3o98A:
20.06
4uh6B-3o98A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH6_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.20A 4uh6A-3o98A:
undetectable
4uh6B-3o98A:
undetectable		 4uh6A-3o98A:
20.06
4uh6B-3o98A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3U_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.16A 4v3uA-3o98A:
undetectable
4v3uB-3o98A:
undetectable		 4v3uA-3o98A:
19.78
4v3uB-3o98A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3W_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.18A 4v3wA-3o98A:
undetectable
4v3wB-3o98A:
undetectable		 4v3wA-3o98A:
20.85
4v3wB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.18A 4v3yA-3o98A:
undetectable
4v3yB-3o98A:
undetectable		 4v3yA-3o98A:
20.85
4v3yB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		5 / 12 LEU A 233
GLY A 364
LEU A 365
VAL A 588
THR A 314
 None
 1.18A 4wnwA-3o98A:
undetectable		 4wnwA-3o98A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 6 ALA A 531
LYS A 533
GLN A 568
LEU A 570
 ADP  A3001 (-3.6A)
ADP  A3001 (-2.8A)
ADP  A3001 (-4.0A)
ADP  A3001 (-4.3A)
 1.02A 4xoyA-3o98A:
undetectable		 4xoyA-3o98A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 6 ALA A 531
LYS A 533
GLN A 568
LEU A 570
 ADP  A3001 (-3.6A)
ADP  A3001 (-2.8A)
ADP  A3001 (-4.0A)
ADP  A3001 (-4.3A)
 1.02A 4xp3A-3o98A:
undetectable		 4xp3A-3o98A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 5 LYS A 579
LEU A 597
GLU A 612
TYR A 253
 None
 1.48A 4z4hA-3o98A:
2.5		 4z4hA-3o98A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGL_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.19A 5aglA-3o98A:
undetectable
5aglB-3o98A:
undetectable		 5aglA-3o98A:
20.85
5aglB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGM_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.18A 5agmA-3o98A:
undetectable
5agmB-3o98A:
undetectable		 5agmA-3o98A:
20.85
5agmB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGM_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.19A 5agmA-3o98A:
undetectable
5agmB-3o98A:
undetectable		 5agmA-3o98A:
20.85
5agmB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGN_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 6 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.19A 5agnA-3o98A:
undetectable
5agnB-3o98A:
undetectable		 5agnA-3o98A:
20.85
5agnB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGN_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.18A 5agnA-3o98A:
undetectable
5agnB-3o98A:
undetectable		 5agnA-3o98A:
20.85
5agnB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 6 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.17A 5fvqA-3o98A:
undetectable
5fvqB-3o98A:
undetectable		 5fvqA-3o98A:
20.85
5fvqB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.15A 5fvqA-3o98A:
undetectable
5fvqB-3o98A:
undetectable		 5fvqA-3o98A:
20.85
5fvqB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 6 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.15A 5fvrA-3o98A:
undetectable
5fvrB-3o98A:
undetectable		 5fvrA-3o98A:
20.85
5fvrB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 6 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.15A 5fvrA-3o98A:
undetectable
5fvrB-3o98A:
undetectable		 5fvrA-3o98A:
20.85
5fvrB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVS_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.17A 5fvsA-3o98A:
undetectable
5fvsB-3o98A:
undetectable		 5fvsA-3o98A:
20.85
5fvsB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVS_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.17A 5fvsA-3o98A:
undetectable
5fvsB-3o98A:
undetectable		 5fvsA-3o98A:
20.85
5fvsB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.16A 5fvtA-3o98A:
undetectable
5fvtB-3o98A:
undetectable		 5fvtA-3o98A:
20.85
5fvtB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.17A 5fvtA-3o98A:
undetectable
5fvtB-3o98A:
undetectable		 5fvtA-3o98A:
20.85
5fvtB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVU_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 6 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.18A 5fvuA-3o98A:
undetectable
5fvuB-3o98A:
undetectable		 5fvuA-3o98A:
20.06
5fvuB-3o98A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVW_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.15A 5fvwA-3o98A:
undetectable
5fvwB-3o98A:
undetectable		 5fvwA-3o98A:
20.06
5fvwB-3o98A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVX_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.17A 5fvxA-3o98A:
undetectable
5fvxB-3o98A:
undetectable		 5fvxA-3o98A:
20.06
5fvxB-3o98A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0N_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.19A 5g0nA-3o98A:
undetectable
5g0nB-3o98A:
undetectable		 5g0nA-3o98A:
21.16
5g0nB-3o98A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.20A 5g0pA-3o98A:
undetectable
5g0pB-3o98A:
undetectable		 5g0pA-3o98A:
21.16
5g0pB-3o98A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		3 / 3 HIS A  55
LYS A  56
PHE A  44
 None
 1.43A 5klaA-3o98A:
undetectable		 5klaA-3o98A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_1
(MINERALOCORTICOID
RECEPTOR)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 6 GLN A 201
PHE A  89
THR A 585
PHE A 319
 None
 1.42A 5mwyA-3o98A:
undetectable		 5mwyA-3o98A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNS_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 6 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.17A 5unsA-3o98A:
undetectable
5unsB-3o98A:
undetectable		 5unsA-3o98A:
20.85
5unsB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO2_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.21A 5uo2A-3o98A:
undetectable
5uo2B-3o98A:
undetectable		 5uo2A-3o98A:
20.06
5uo2B-3o98A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUL_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.18A 5vulA-3o98A:
undetectable
5vulB-3o98A:
undetectable		 5vulA-3o98A:
20.85
5vulB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.19A 5vunA-3o98A:
undetectable
5vunB-3o98A:
undetectable		 5vunA-3o98A:
20.85
5vunB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.20A 5vuoA-3o98A:
undetectable
5vuoB-3o98A:
undetectable		 5vuoA-3o98A:
20.85
5vuoB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUP_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.18A 5vupA-3o98A:
undetectable
5vupB-3o98A:
undetectable		 5vupA-3o98A:
20.85
5vupB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUQ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.18A 5vuqA-3o98A:
undetectable
5vuqB-3o98A:
undetectable		 5vuqA-3o98A:
20.85
5vuqB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUT_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.19A 5vutA-3o98A:
undetectable
5vutB-3o98A:
undetectable		 5vutA-3o98A:
20.85
5vutB-3o98A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUW_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.14A 5vuwA-3o98A:
undetectable
5vuwB-3o98A:
undetectable		 5vuwA-3o98A:
20.06
5vuwB-3o98A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUZ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.21A 5vuzA-3o98A:
undetectable
5vuzB-3o98A:
undetectable		 5vuzA-3o98A:
20.06
5vuzB-3o98A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUR_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.18A 6aurA-3o98A:
undetectable
6aurB-3o98A:
undetectable		 6aurA-3o98A:
7.11
6aurB-3o98A:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUS_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.18A 6ausA-3o98A:
undetectable
6ausB-3o98A:
undetectable		 6ausA-3o98A:
7.11
6ausB-3o98A:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUS_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.19A 6ausA-3o98A:
undetectable
6ausB-3o98A:
undetectable		 6ausA-3o98A:
7.11
6ausB-3o98A:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUT_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.18A 6autA-3o98A:
undetectable
6autB-3o98A:
undetectable		 6autA-3o98A:
7.11
6autB-3o98A:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.18A 6auuA-3o98A:
undetectable
6auuB-3o98A:
undetectable		 6auuA-3o98A:
7.11
6auuB-3o98A:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUV_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.17A 6auvA-3o98A:
undetectable
6auvB-3o98A:
undetectable		 6auvA-3o98A:
7.11
6auvB-3o98A:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUY_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.17A 6auyA-3o98A:
undetectable
6auyB-3o98A:
undetectable		 6auyA-3o98A:
8.24
6auyB-3o98A:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUZ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.17A 6auzA-3o98A:
undetectable
6auzB-3o98A:
undetectable		 6auzA-3o98A:
8.24
6auzB-3o98A:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUZ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.19A 6auzA-3o98A:
undetectable
6auzB-3o98A:
undetectable		 6auzA-3o98A:
8.24
6auzB-3o98A:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV3_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 ARG A  64
VAL A 132
PHE A  75
GLU A  83
 TS5  A 620 (-2.3A)
None
None
None
 1.17A 6av3A-3o98A:
undetectable
6av3B-3o98A:
undetectable		 6av3A-3o98A:
8.24
6av3B-3o98A:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV3_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.21A 6av3A-3o98A:
undetectable
6av3B-3o98A:
undetectable		 6av3A-3o98A:
8.24
6av3B-3o98A:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CID_B_H4BB803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 7 PHE A  75
GLU A  83
ARG A  64
VAL A 132
 None
None
TS5  A 620 (-2.3A)
None
 1.20A 6cidA-3o98A:
undetectable
6cidB-3o98A:
undetectable		 6cidA-3o98A:
8.24
6cidB-3o98A:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_1
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE
(Escherichia
coli) 		4 / 5 GLN A 239
GLU A 229
ASP A 231
ASN A 241
 None
 1.39A 6iftA-3o98A:
undetectable		 6iftA-3o98A:
19.30