SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3oa0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_A_T44A428_1
(TRANSTHYRETIN
THR119MET VARIANT)		 3oa0 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WBPB
(Thermus
thermophilus) 		4 / 4 LYS A 150
LEU A 143
ALA A 219
LEU A 193
 None
 1.50A 1f86A-3oa0A:
undetectable		 1f86A-3oa0A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3oa0 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WBPB
(Thermus
thermophilus) 		4 / 7 VAL A 221
VAL A 288
LEU A 291
LEU A 216
 None
 0.88A 1pthA-3oa0A:
undetectable		 1pthA-3oa0A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3oa0 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WBPB
(Thermus
thermophilus) 		4 / 7 VAL A 221
VAL A 288
LEU A 291
LEU A 216
 None
 0.88A 1pthB-3oa0A:
undetectable		 1pthB-3oa0A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3oa0 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WBPB
(Thermus
thermophilus) 		5 / 10 LEU A  61
ALA A  90
ALA A  77
LEU A   9
PHE A  57
 None
None
NAD  A 311 (-4.5A)
None
None
 1.19A 1xp0A-3oa0A:
undetectable		 1xp0A-3oa0A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3oa0 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WBPB
(Thermus
thermophilus) 		4 / 6 PHE A 187
ILE A 184
GLY A 177
GLY A 176
 None
 0.82A 2qx6A-3oa0A:
4.0
2qx6B-3oa0A:
4.8		 2qx6A-3oa0A:
24.46
2qx6B-3oa0A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 3oa0 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WBPB
(Thermus
thermophilus) 		4 / 7 SER A 246
TYR A 244
THR A 155
VAL A 153
 None
 1.05A 2uz2A-3oa0A:
undetectable		 2uz2A-3oa0A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3oa0 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WBPB
(Thermus
thermophilus) 		4 / 8 ALA A  95
LEU A  74
ALA A   5
PHE A  57
 None
 0.83A 2vcvP-3oa0A:
undetectable		 2vcvP-3oa0A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 3oa0 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WBPB
(Thermus
thermophilus) 		3 / 3 ARG A 305
ARG A 222
PRO A 302
 None
 0.93A 2wljA-3oa0A:
undetectable		 2wljA-3oa0A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 3oa0 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WBPB
(Thermus
thermophilus) 		4 / 4 GLY A  39
VAL A  41
GLY A   8
THR A   7
 None
None
NAD  A 311 (-3.4A)
NAD  A 311 ( 4.3A)
 0.90A 3ib2A-3oa0A:
undetectable		 3ib2A-3oa0A:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 3oa0 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WBPB
(Thermus
thermophilus) 		5 / 12 GLY A   8
ASP A  33
PRO A  34
ALA A  35
ILE A  13
 NAD  A 311 (-3.4A)
NAD  A 311 (-2.7A)
NAD  A 311 (-4.2A)
NAD  A 311 (-3.6A)
NAD  A 311 (-4.0A)
 0.89A 3jb1A-3oa0A:
undetectable		 3jb1A-3oa0A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3oa0 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WBPB
(Thermus
thermophilus) 		5 / 12 HIS A 264
LEU A  18
TYR A 268
GLY A   8
SER A  31
 NAD  A 311 (-4.6A)
None
None
NAD  A 311 (-3.4A)
None
 1.25A 3n8xA-3oa0A:
0.1		 3n8xA-3oa0A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 3oa0 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WBPB
(Thermus
thermophilus) 		4 / 5 HIS A 203
GLY A 212
TYR A 213
GLU A 303
 None
 1.26A 4ae1B-3oa0A:
undetectable		 4ae1B-3oa0A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 3oa0 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WBPB
(Thermus
thermophilus) 		4 / 8 SER A 167
ILE A 182
LEU A 178
ILE A 227
 None
 0.86A 4dtaB-3oa0A:
undetectable		 4dtaB-3oa0A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 3oa0 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WBPB
(Thermus
thermophilus) 		5 / 12 LEU A 178
GLY A 183
LEU A 154
VAL A 157
HIS A 306
 None
 1.01A 4olmA-3oa0A:
undetectable		 4olmA-3oa0A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 3oa0 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WBPB
(Thermus
thermophilus) 		5 / 12 VAL A 221
ASP A 250
LEU A 143
PHE A 194
GLY A 218
 None
 1.18A 4pevC-3oa0A:
3.6		 4pevC-3oa0A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3oa0 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WBPB
(Thermus
thermophilus) 		4 / 4 GLU A 109
PRO A 107
ILE A 286
LEU A 105
 None
 1.19A 5m45A-3oa0A:
undetectable		 5m45A-3oa0A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3oa0 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WBPB
(Thermus
thermophilus) 		4 / 4 GLU A 109
PRO A 107
ILE A 286
LEU A 105
 None
 1.18A 5m45D-3oa0A:
undetectable		 5m45D-3oa0A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3oa0 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WBPB
(Thermus
thermophilus) 		4 / 4 GLU A 109
PRO A 107
ILE A 286
LEU A 105
 None
 1.18A 5m45G-3oa0A:
undetectable		 5m45G-3oa0A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3oa0 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WBPB
(Thermus
thermophilus) 		4 / 4 GLU A 109
PRO A 107
ILE A 286
LEU A 105
 None
 1.16A 5m45J-3oa0A:
undetectable		 5m45J-3oa0A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 3oa0 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WBPB
(Thermus
thermophilus) 		4 / 7 ARG A  16
ALA A  20
ILE A  13
ALA A  14
 HP7  A 312 ( 3.6A)
None
NAD  A 311 (-4.0A)
None
 0.99A 6ma7A-3oa0A:
undetectable		 6ma7A-3oa0A:
13.42