SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3oa2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 3oa2 WBPB
(Pseudomonas
aeruginosa) 		5 / 12 ALA A   9
SER A  48
PHE A  50
GLY A  39
ILE A  40
 None
 0.89A 1kglA-3oa2A:
undetectable		 1kglA-3oa2A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3oa2 WBPB
(Pseudomonas
aeruginosa) 		4 / 5 ASP A  33
GLY A  39
PRO A  15
ALA A  14
 NAD  A 317 (-2.7A)
None
None
None
 0.95A 2aohA-3oa2A:
undetectable		 2aohA-3oa2A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 3oa2 WBPB
(Pseudomonas
aeruginosa) 		4 / 5 LEU A 193
LEU A 131
CYH A 287
THR A 290
 None
 1.37A 2oaxD-3oa2A:
undetectable		 2oaxD-3oa2A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3oa2 WBPB
(Pseudomonas
aeruginosa) 		5 / 12 THR A 208
VAL A 205
THR A 107
GLY A 180
ALA A 182
 None
 1.06A 2x2iC-3oa2A:
undetectable		 2x2iC-3oa2A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 3oa2 WBPB
(Pseudomonas
aeruginosa) 		3 / 3 SER A 178
GLU A 210
ASP A 174
 None
 0.80A 2zthA-3oa2A:
2.3		 2zthA-3oa2A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 3oa2 WBPB
(Pseudomonas
aeruginosa) 		5 / 11 VAL A  98
GLY A  91
THR A 121
ILE A 117
LEU A 114
 None
 1.39A 3bf1E-3oa2A:
undetectable
3bf1F-3oa2A:
undetectable		 3bf1E-3oa2A:
22.53
3bf1F-3oa2A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 3oa2 WBPB
(Pseudomonas
aeruginosa) 		3 / 3 SER A 178
GLU A 210
ASP A 174
 None
 0.83A 3bwmA-3oa2A:
5.0		 3bwmA-3oa2A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 3oa2 WBPB
(Pseudomonas
aeruginosa) 		3 / 3 SER A 178
GLU A 210
ASP A 174
 None
 0.84A 3bwyA-3oa2A:
4.7		 3bwyA-3oa2A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 3oa2 WBPB
(Pseudomonas
aeruginosa) 		4 / 6 SER A  79
ARG A  93
GLY A  91
GLU A 120
 None
 0.83A 3k9fA-3oa2A:
undetectable
3k9fB-3oa2A:
undetectable
3k9fD-3oa2A:
undetectable		 3k9fA-3oa2A:
21.46
3k9fB-3oa2A:
21.46
3k9fD-3oa2A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 3oa2 WBPB
(Pseudomonas
aeruginosa) 		4 / 8 ASP A 234
SER A 229
PHE A 207
SER A 209
 None
 0.94A 3m0wE-3oa2A:
undetectable
3m0wF-3oa2A:
undetectable
3m0wG-3oa2A:
undetectable
3m0wH-3oa2A:
undetectable		 3m0wE-3oa2A:
14.10
3m0wF-3oa2A:
14.10
3m0wG-3oa2A:
14.10
3m0wH-3oa2A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3oa2 WBPB
(Pseudomonas
aeruginosa) 		3 / 3 TYR A 126
GLY A 280
ASP A 283
 None
 0.72A 3ou6C-3oa2A:
3.6		 3ou6C-3oa2A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 3oa2 WBPB
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  21
TYR A 270
ALA A   5
LEU A  28
GLY A  91
 None
 1.05A 3ozwB-3oa2A:
4.0		 3ozwB-3oa2A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 3oa2 WBPB
(Pseudomonas
aeruginosa) 		4 / 8 HIS A 134
ILE A 137
ILE A 249
ARG A 247
 None
 1.10A 3sfeB-3oa2A:
undetectable
3sfeC-3oa2A:
undetectable		 3sfeB-3oa2A:
23.21
3sfeC-3oa2A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3oa2 WBPB
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  28
ILE A   7
ILE A  41
ILE A  40
ALA A  14
 None
 1.28A 3uj7A-3oa2A:
undetectable		 3uj7A-3oa2A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 3oa2 WBPB
(Pseudomonas
aeruginosa) 		5 / 11 HIS A  87
SER A  79
GLU A 101
LEU A 129
LEU A 125
 NAD  A 317 (-4.4A)
None
NAD  A 317 (-3.2A)
None
None
 1.32A 4foxC-3oa2A:
undetectable		 4foxC-3oa2A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3oa2 WBPB
(Pseudomonas
aeruginosa) 		4 / 8 ARG A 225
PRO A 236
SER A 238
VAL A 239
 None
 0.97A 4mk4A-3oa2A:
2.3		 4mk4A-3oa2A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3oa2 WBPB
(Pseudomonas
aeruginosa) 		3 / 3 SER A 178
GLU A 210
ASP A 174
 None
 0.86A 4xudA-3oa2A:
5.0		 4xudA-3oa2A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3oa2 WBPB
(Pseudomonas
aeruginosa) 		4 / 6 SER A  30
HIS A  60
LEU A  72
LEU A  94
 None
 1.33A 5dzke-3oa2A:
undetectable
5dzks-3oa2A:
undetectable		 5dzke-3oa2A:
22.26
5dzks-3oa2A:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 3oa2 WBPB
(Pseudomonas
aeruginosa) 		4 / 8 HIS A 308
GLY A 215
VAL A 311
ASP A 156
 None
 0.80A 5f8yA-3oa2A:
undetectable		 5f8yA-3oa2A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3oa2 WBPB
(Pseudomonas
aeruginosa) 		4 / 7 HIS A 133
HIS A 188
ILE A 128
TYR A 279
 None
 1.15A 5kkzC-3oa2A:
undetectable
5kkzE-3oa2A:
undetectable		 5kkzC-3oa2A:
20.65
5kkzE-3oa2A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3oa2 WBPB
(Pseudomonas
aeruginosa) 		4 / 7 HIS A 188
ILE A 128
TYR A 279
HIS A 133
 None
 1.15A 5kkzK-3oa2A:
undetectable
5kkzQ-3oa2A:
undetectable		 5kkzK-3oa2A:
21.35
5kkzQ-3oa2A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3oa2 WBPB
(Pseudomonas
aeruginosa) 		4 / 7 HIS A 133
HIS A 188
ILE A 128
TYR A 279
 None
 1.08A 5kkzM-3oa2A:
undetectable
5kkzO-3oa2A:
undetectable		 5kkzM-3oa2A:
20.65
5kkzO-3oa2A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 3oa2 WBPB
(Pseudomonas
aeruginosa) 		4 / 7 ARG A  16
ALA A  20
ILE A  13
ALA A  14
 None
None
NAD  A 317 (-3.8A)
None
 0.99A 6ma7A-3oa2A:
undetectable		 6ma7A-3oa2A:
14.14