SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3oa3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3oa3 ALDOLASE
(Coccidioides
immitis) 		5 / 12 ILE A 169
GLY A 172
CYH A 173
SER A 177
LEU A 210
 None
 1.31A 1fm6X-3oa3A:
undetectable		 1fm6X-3oa3A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3oa3 ALDOLASE
(Coccidioides
immitis) 		5 / 10 ILE A  40
ALA A  68
ASP A  42
ILE A 247
ILE A  37
 ACT  A 268 ( 4.5A)
None
None
None
ACT  A 268 ( 4.9A)
 1.23A 1rb3A-3oa3A:
undetectable		 1rb3A-3oa3A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 3oa3 ALDOLASE
(Coccidioides
immitis) 		5 / 12 SER A 103
ARG A 147
VAL A 108
LEU A 122
ILE A  95
 None
 1.48A 2fj1A-3oa3A:
undetectable		 2fj1A-3oa3A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 3oa3 ALDOLASE
(Coccidioides
immitis) 		4 / 7 ILE A  41
ARG A 238
ASP A 123
GLU A 121
 None
 1.05A 2qebA-3oa3A:
undetectable		 2qebA-3oa3A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 3oa3 ALDOLASE
(Coccidioides
immitis) 		4 / 7 ILE A  41
ARG A 238
ASP A 123
GLU A 121
 None
 1.01A 2qebB-3oa3A:
undetectable		 2qebB-3oa3A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 3oa3 ALDOLASE
(Coccidioides
immitis) 		4 / 6 LEU A 210
SER A 212
THR A 214
VAL A 216
 None
 0.97A 3d2tB-3oa3A:
undetectable		 3d2tB-3oa3A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3oa3 ALDOLASE
(Coccidioides
immitis) 		3 / 3 VAL A 184
SER A 176
LEU A 159
 None
 0.65A 3n8xA-3oa3A:
undetectable		 3n8xA-3oa3A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WFA_B_EDTB802_0
(ALPHA-GLUCOSIDASE)		 3oa3 ALDOLASE
(Coccidioides
immitis) 		4 / 6 TYR A 102
ASP A 142
ASN A 127
TYR A 128
 None
 1.26A 3wfaA-3oa3A:
6.5
3wfaB-3oa3A:
5.3		 3wfaA-3oa3A:
17.37
3wfaB-3oa3A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 3oa3 ALDOLASE
(Coccidioides
immitis) 		4 / 5 SER A 201
VAL A 200
GLY A 235
ALA A 234
 None
 1.05A 5k50A-3oa3A:
undetectable		 5k50A-3oa3A:
20.41