SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3oai'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0
(Escherichia
coli;
Homo
sapiens) 		4 / 6 VAL A   8
VAL A  50
ILE A  60
ASN A 267
 None
 0.96A 1e06A-3oaiA:
undetectable		 1e06A-3oaiA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_2
(HIV-II PROTEASE)		 3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0
(Escherichia
coli;
Homo
sapiens) 		6 / 9 ALA A 276
ILE A   9
VAL A  35
ILE A   2
ILE A  60
ILE A  59
 None
 1.48A 1hshB-3oaiA:
undetectable		 1hshB-3oaiA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0
(Escherichia
coli;
Homo
sapiens) 		5 / 10 LEU A 192
LEU A 195
ILE A 161
GLU A 153
LEU A 151
 None
None
None
MAL  A1122 (-3.6A)
None
 1.17A 1wopA-3oaiA:
undetectable		 1wopA-3oaiA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0
(Escherichia
coli;
Homo
sapiens) 		5 / 12 LEU A 262
ILE A 108
VAL A  97
LEU A  76
ILE A  79
 None
 1.07A 2h42C-3oaiA:
undetectable		 2h42C-3oaiA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0
(Escherichia
coli;
Homo
sapiens) 		5 / 10 PHE A1066
TYR A1039
ASP A1092
ILE A1085
VAL A1017
 None
 1.45A 2qboA-3oaiA:
undetectable		 2qboA-3oaiA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0
(Escherichia
coli;
Homo
sapiens) 		5 / 12 ALA A 264
LEU A 280
PHE A 279
VAL A 293
GLY A  16
 None
 1.11A 2ve3A-3oaiA:
undetectable		 2ve3A-3oaiA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0
(Escherichia
coli;
Homo
sapiens) 		4 / 8 THR A  93
LEU A 285
ASP A 287
GLU A 111
 None
None
None
MAL  A1122 (-2.9A)
 1.04A 2zw9A-3oaiA:
undetectable		 2zw9A-3oaiA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0
(Escherichia
coli;
Homo
sapiens) 		5 / 12 LEU A 192
THR A 193
ALA A 346
THR A 345
ILE A 348
 None
 1.22A 3a35A-3oaiA:
undetectable		 3a35A-3oaiA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0
(Escherichia
coli;
Homo
sapiens) 		4 / 6 PHE A 258
ALA A 162
LEU A 247
PRO A 159
 None
 0.95A 3bgdA-3oaiA:
undetectable		 3bgdA-3oaiA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)		 3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0
(Escherichia
coli;
Homo
sapiens) 		4 / 7 VAL A 110
GLY A 300
PRO A 229
LYS A 305
 None
 0.68A 3bjwC-3oaiA:
undetectable		 3bjwC-3oaiA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0
(Escherichia
coli;
Homo
sapiens) 		4 / 6 PRO A 126
LEU A 147
ALA A 223
PRO A 125
 None
 1.32A 3gv1A-3oaiA:
undetectable
3gv1C-3oaiA:
undetectable		 3gv1A-3oaiA:
14.00
3gv1C-3oaiA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0
(Escherichia
coli;
Homo
sapiens) 		4 / 6 LEU A 147
ALA A 223
PRO A 125
PRO A 126
 None
 1.30A 3gv1A-3oaiA:
undetectable
3gv1B-3oaiA:
undetectable		 3gv1A-3oaiA:
14.00
3gv1B-3oaiA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0
(Escherichia
coli;
Homo
sapiens) 		5 / 12 VAL A 343
GLY A 187
ALA A 188
LEU A 192
LEU A 160
 None
 1.04A 3hs6A-3oaiA:
undetectable		 3hs6A-3oaiA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0
(Escherichia
coli;
Homo
sapiens) 		3 / 3 SER A1049
ASP A1061
ASP A1099
 None
 0.87A 3iv6A-3oaiA:
undetectable		 3iv6A-3oaiA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0
(Escherichia
coli;
Homo
sapiens) 		3 / 3 SER A1049
ASP A1061
ASP A1099
 None
 0.87A 3iv6C-3oaiA:
undetectable		 3iv6C-3oaiA:
18.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0
(Escherichia
coli;
Homo
sapiens) 		9 / 12 ASP A  14
LYS A  15
GLU A  44
GLU A  45
ALA A  63
ASP A  65
ARG A  66
GLU A 111
TRP A 230
 MAL  A1122 (-3.3A)
MAL  A1122 (-2.7A)
MAL  A1122 ( 4.8A)
None
MAL  A1122 (-3.3A)
MAL  A1122 (-2.9A)
MAL  A1122 (-3.8A)
MAL  A1122 (-2.9A)
MAL  A1122 ( 4.7A)
 0.86A 3jyrA-3oaiA:
62.1		 3jyrA-3oaiA:
69.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0
(Escherichia
coli;
Homo
sapiens) 		9 / 12 ASP A  14
LYS A  15
GLU A  44
GLU A  45
ALA A  63
ASP A  65
GLU A 111
PRO A 154
TRP A 230
 MAL  A1122 (-3.3A)
MAL  A1122 (-2.7A)
MAL  A1122 ( 4.8A)
None
MAL  A1122 (-3.3A)
MAL  A1122 (-2.9A)
MAL  A1122 (-2.9A)
MAL  A1122 (-3.5A)
MAL  A1122 ( 4.7A)
 0.66A 3jyrA-3oaiA:
62.1		 3jyrA-3oaiA:
69.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0
(Escherichia
coli;
Homo
sapiens) 		7 / 7 ASN A  12
TRP A  62
GLU A 153
TYR A 155
MET A 330
TRP A 340
ARG A 344
 MAL  A1122 ( 4.2A)
MAL  A1122 (-4.4A)
MAL  A1122 (-3.6A)
MAL  A1122 (-3.8A)
MAL  A1122 ( 4.1A)
MAL  A1122 (-3.7A)
None
 0.65A 3jyrA-3oaiA:
62.1		 3jyrA-3oaiA:
69.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0
(Escherichia
coli;
Homo
sapiens) 		5 / 9 ILE A 132
LEU A 198
LYS A 256
ILE A 226
GLY A 191
 None
 1.26A 3sj4X-3oaiA:
undetectable		 3sj4X-3oaiA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0
(Escherichia
coli;
Homo
sapiens) 		5 / 12 PHE A 156
GLY A 300
LEU A 299
GLU A 111
ALA A 231
 None
None
None
MAL  A1122 (-2.9A)
None
 0.83A 3tbgB-3oaiA:
undetectable		 3tbgB-3oaiA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0
(Escherichia
coli;
Homo
sapiens) 		5 / 12 PHE A 156
GLY A 300
LEU A 299
GLU A 111
ALA A 231
 None
None
None
MAL  A1122 (-2.9A)
None
 0.82A 3tbgD-3oaiA:
undetectable		 3tbgD-3oaiA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0
(Escherichia
coli;
Homo
sapiens) 		5 / 12 ALA A 231
TYR A  17
TYR A 210
ASN A 234
GLY A 228
 None
 1.36A 3vwqA-3oaiA:
undetectable		 3vwqA-3oaiA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)		 3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0
(Escherichia
coli;
Homo
sapiens) 		5 / 9 ALA A 264
ALA A 105
LEU A 103
LEU A 262
VAL A 261
 None
 1.13A 4or0B-3oaiA:
undetectable		 4or0B-3oaiA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0
(Escherichia
coli;
Homo
sapiens) 		6 / 12 ALA A 342
ALA A 338
GLY A 166
ALA A 188
PHE A 169
VAL A 181
 None
 1.40A 5w4zA-3oaiA:
undetectable		 5w4zA-3oaiA:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0
(Escherichia
coli;
Homo
sapiens) 		6 / 12 ALA A 342
ALA A 338
GLY A 166
ALA A 188
PHE A 169
VAL A 181
 None
 1.43A 5w4zB-3oaiA:
undetectable		 5w4zB-3oaiA:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)		 3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0
(Escherichia
coli;
Homo
sapiens) 		5 / 12 GLY A 260
LYS A 297
ASP A 296
VAL A 293
ILE A  11
 None
 1.02A 5wz1A-3oaiA:
undetectable		 5wz1A-3oaiA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)		 3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0
(Escherichia
coli;
Homo
sapiens) 		5 / 12 GLY A 260
LYS A 297
ASP A 296
VAL A 293
ILE A  11
 None
 1.04A 5wz1C-3oaiA:
undetectable		 5wz1C-3oaiA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)		 3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0
(Escherichia
coli;
Homo
sapiens) 		5 / 12 GLY A 260
LYS A 297
ASP A 296
VAL A 293
ILE A  11
 None
 1.03A 5wz1G-3oaiA:
undetectable		 5wz1G-3oaiA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_H_SAMH601_0
(NS5
METHYLTRANSFERASE)		 3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0
(Escherichia
coli;
Homo
sapiens) 		5 / 12 GLY A 260
LYS A 297
ASP A 296
VAL A 293
ILE A  11
 None
 1.03A 5wz1H-3oaiA:
undetectable		 5wz1H-3oaiA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0
(Escherichia
coli;
Homo
sapiens) 		3 / 3 TYR A 155
ASN A 227
LEU A 113
 MAL  A1122 (-3.8A)
None
None
 0.83A 6b58A-3oaiA:
undetectable		 6b58A-3oaiA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0
(Escherichia
coli;
Homo
sapiens) 		5 / 11 PRO A 133
GLU A 130
PRO A 254
ALA A 163
PRO A 159
 None
 1.47A 6bm5A-3oaiA:
undetectable		 6bm5A-3oaiA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0
(Escherichia
coli;
Homo
sapiens) 		5 / 12 LEU A 275
GLY A  24
VAL A  35
LEU A   7
ILE A   9
 None
 0.92A 6ecxA-3oaiA:
undetectable		 6ecxA-3oaiA:
20.82