SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3oak'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3oak TRANSCRIPTION FACTOR
IWS1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 221
LEU A 225
VAL A 200
ALA A 245
LEU A 246
 None
 1.07A 3ln1B-3oakA:
undetectable		 3ln1B-3oakA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3oak TRANSCRIPTION FACTOR
IWS1
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 274
SER A 271
LEU A 233
 None
 0.72A 3n8xA-3oakA:
undetectable		 3n8xA-3oakA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 3oak TRANSCRIPTION FACTOR
IWS1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 221
LEU A 225
VAL A 200
ALA A 245
LEU A 246
 None
 1.05A 3nt1A-3oakA:
undetectable		 3nt1A-3oakA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 3oak TRANSCRIPTION FACTOR
IWS1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 221
LEU A 225
VAL A 200
ALA A 245
LEU A 246
 None
 1.03A 3nt1B-3oakA:
undetectable		 3nt1B-3oakA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 3oak TRANSCRIPTION FACTOR
IWS1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 221
LEU A 225
VAL A 200
ALA A 245
LEU A 246
 None
 1.07A 3pghD-3oakA:
0.2		 3pghD-3oakA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 3oak TRANSCRIPTION FACTOR
IWS1
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 153
ARG A 160
LYS A 157
 None
 1.31A 4wq5B-3oakA:
undetectable		 4wq5B-3oakA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 3oak TRANSCRIPTION FACTOR
IWS1
(Saccharomyces
cerevisiae) 		5 / 9 ILE A 158
MET A 165
VAL A 251
LEU A 249
LEU A 154
 None
 1.17A 5iepA-3oakA:
undetectable		 5iepA-3oakA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3oak TRANSCRIPTION FACTOR
IWS1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 221
LEU A 225
VAL A 200
ALA A 245
LEU A 246
 None
 1.08A 5jvzA-3oakA:
undetectable		 5jvzA-3oakA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 3oak TRANSCRIPTION FACTOR
IWS1
(Saccharomyces
cerevisiae) 		6 / 12 ASP A 163
GLU A 164
LEU A 225
LEU A 242
ARG A 222
LEU A 217
 None
 1.30A 6ew0B-3oakA:
undetectable		 6ew0B-3oakA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 3oak TRANSCRIPTION FACTOR
IWS1
(Saccharomyces
cerevisiae) 		6 / 12 ASP A 163
GLU A 164
LEU A 225
LEU A 242
ARG A 222
LEU A 217
 None
 1.29A 6ew0D-3oakA:
undetectable		 6ew0D-3oakA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 3oak TRANSCRIPTION FACTOR
IWS1
(Saccharomyces
cerevisiae) 		6 / 12 ASP A 163
GLU A 164
LEU A 225
LEU A 242
ARG A 222
LEU A 217
 None
 1.30A 6ew0F-3oakA:
undetectable		 6ew0F-3oakA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 3oak TRANSCRIPTION FACTOR
IWS1
(Saccharomyces
cerevisiae) 		6 / 12 ASP A 163
GLU A 164
LEU A 225
LEU A 242
ARG A 222
LEU A 217
 None
 1.30A 6ew0G-3oakA:
undetectable		 6ew0G-3oakA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 3oak TRANSCRIPTION FACTOR
IWS1
(Saccharomyces
cerevisiae) 		6 / 12 ASP A 163
GLU A 164
LEU A 225
LEU A 242
ARG A 222
LEU A 217
 None
 1.29A 6ew0H-3oakA:
undetectable		 6ew0H-3oakA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 3oak TRANSCRIPTION FACTOR
IWS1
(Saccharomyces
cerevisiae) 		6 / 12 ASP A 163
GLU A 164
LEU A 225
LEU A 242
ARG A 222
LEU A 217
 None
 1.29A 6ew0I-3oakA:
undetectable		 6ew0I-3oakA:
15.58