SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3obi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3obi FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Rhodopseudomonas
palustris) 		5 / 10 ALA A 120
SER A  96
LEU A 102
ALA A 172
PHE A 140
 None
 1.18A 1g5yC-3obiA:
undetectable		 1g5yC-3obiA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 3obi FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Rhodopseudomonas
palustris) 		5 / 12 PHE A 130
ILE A 121
ASP A 137
GLY A 136
PHE A 135
 None
 1.25A 1hvyA-3obiA:
undetectable		 1hvyA-3obiA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 3obi FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Rhodopseudomonas
palustris) 		5 / 11 PHE A 130
ILE A 121
ASP A 137
GLY A 136
PHE A 135
 None
 1.30A 1hvyC-3obiA:
undetectable		 1hvyC-3obiA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 3obi FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Rhodopseudomonas
palustris) 		5 / 11 PHE A 130
ILE A 121
ASP A 137
GLY A 136
PHE A 135
 None
 1.08A 1ju6A-3obiA:
undetectable		 1ju6A-3obiA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 3obi FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Rhodopseudomonas
palustris) 		4 / 6 ASP A 236
GLY A 219
ILE A 218
ILE A 193
 None
 0.82A 1n49D-3obiA:
undetectable		 1n49D-3obiA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 3obi FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Rhodopseudomonas
palustris) 		5 / 10 PHE A 130
ILE A 121
ASP A 137
GLY A 136
PHE A 135
 None
 1.38A 2tsrC-3obiA:
undetectable		 2tsrC-3obiA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 3obi FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Rhodopseudomonas
palustris) 		5 / 9 PHE A 130
ILE A 121
ASP A 137
GLY A 136
PHE A 135
 None
 1.36A 2tsrD-3obiA:
undetectable		 2tsrD-3obiA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3obi FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Rhodopseudomonas
palustris) 		4 / 6 PHE A  53
TYR A   6
ARG A  66
THR A   9
 None
None
None
EDO  A 308 ( 4.4A)
 1.41A 2x2iB-3obiA:
1.4		 2x2iB-3obiA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 3obi FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Rhodopseudomonas
palustris) 		5 / 12 MET A 175
ILE A 177
LEU A 178
ASN A 192
VAL A 225
 None
 0.76A 3dcjA-3obiA:
18.5
3dcjB-3obiA:
18.9		 3dcjA-3obiA:
28.04
3dcjB-3obiA:
28.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 3obi FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Rhodopseudomonas
palustris) 		4 / 8 ILE A 177
LEU A 178
ASN A 192
VAL A 225
 None
 0.75A 3dcjB-3obiA:
19.0		 3dcjB-3obiA:
28.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 3obi FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Rhodopseudomonas
palustris) 		5 / 9 PHE A 130
ILE A 121
ASP A 137
GLY A 136
PHE A 135
 None
 1.42A 4eb4C-3obiA:
undetectable		 4eb4C-3obiA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3obi FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Rhodopseudomonas
palustris) 		3 / 3 PHE A 133
VAL A  95
ILE A 121
 None
 0.56A 4emaA-3obiA:
undetectable		 4emaA-3obiA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 3obi FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Rhodopseudomonas
palustris) 		3 / 3 ASP A 272
ARG A  85
ASP A 113
 None
 0.84A 4fp9A-3obiA:
2.5		 4fp9A-3obiA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 3obi FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Rhodopseudomonas
palustris) 		3 / 3 ASP A 272
ARG A  85
ASP A 113
 None
 0.82A 4fp9C-3obiA:
2.3		 4fp9C-3obiA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 3obi FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Rhodopseudomonas
palustris) 		3 / 3 ASP A 272
ARG A  85
ASP A 113
 None
 0.78A 4fp9F-3obiA:
2.4		 4fp9F-3obiA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 3obi FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Rhodopseudomonas
palustris) 		4 / 7 LEU A  93
LEU A 267
ASN A 192
ILE A 191
 None
 0.88A 4rmjA-3obiA:
4.1		 4rmjA-3obiA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)		 3obi FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Rhodopseudomonas
palustris) 		5 / 7 PHE A 130
ILE A 121
ASP A 137
GLY A 136
PHE A 135
 None
 1.50A 5h3aA-3obiA:
undetectable		 5h3aA-3obiA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 3obi FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Rhodopseudomonas
palustris) 		5 / 12 ILE A  72
LEU A  10
PHE A  69
ARG A  66
GLY A  70
 None
 1.32A 5k7uA-3obiA:
undetectable		 5k7uA-3obiA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3obi FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Rhodopseudomonas
palustris) 		4 / 6 LEU A 171
ILE A 138
TRP A 109
MET A 116
 None
 1.39A 5ljeA-3obiA:
undetectable		 5ljeA-3obiA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WQP_A_NCAA302_0
(PROBABLE
DEHYDROGENASE)		 3obi FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Rhodopseudomonas
palustris) 		4 / 8 SER A  96
GLN A  97
TYR A 174
HIS A 125
 None
 1.29A 5wqpA-3obiA:
3.1		 5wqpA-3obiA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA717_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3obi FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Rhodopseudomonas
palustris) 		4 / 5 SER A 243
ARG A 245
ASP A 246
LYS A 254
 None
 0.93A 6dwdA-3obiA:
undetectable		 6dwdA-3obiA:
18.65