SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3obk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3obk DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Toxoplasma
gondii) 		5 / 12 HIS A 291
MET A 179
LEU A 208
MET A 265
LEU A 318
 None
 1.40A 1fm6D-3obkA:
undetectable		 1fm6D-3obkA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 3obk DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Toxoplasma
gondii) 		5 / 12 GLU A 252
MET A 186
ILE A 156
GLY A 147
HIS A 145
 MG  A 365 (-2.5A)
None
None
None
None
 1.23A 1g50B-3obkA:
undetectable		 1g50B-3obkA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 3obk DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Toxoplasma
gondii) 		5 / 11 GLU A 252
MET A 186
ILE A 156
GLY A 147
HIS A 145
 MG  A 365 (-2.5A)
None
None
None
None
 1.22A 1g50C-3obkA:
undetectable		 1g50C-3obkA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3obk DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Toxoplasma
gondii) 		4 / 6 ALA A 121
LEU A 114
LEU A  92
LEU A  70
 None
None
None
EDO  A 385 (-4.3A)
 1.00A 1mt1D-3obkA:
undetectable
1mt1E-3obkA:
undetectable		 1mt1D-3obkA:
17.05
1mt1E-3obkA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3obk DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Toxoplasma
gondii) 		4 / 6 ALA A 121
LEU A 115
LEU A 131
LEU A  50
 None
 0.76A 1mt1D-3obkA:
undetectable
1mt1E-3obkA:
undetectable		 1mt1D-3obkA:
17.05
1mt1E-3obkA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 3obk DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Toxoplasma
gondii) 		5 / 12 LEU A 172
LEU A 115
LEU A 114
MET A  72
LEU A 131
 None
 1.49A 1sqnA-3obkA:
undetectable		 1sqnA-3obkA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DMG_A_SAMA401_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493)		 3obk DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Toxoplasma
gondii) 		5 / 12 ARG A 189
GLU A 107
ALA A 105
ASP A 146
PRO A 139
 MG  A 365 ( 4.7A)
None
None
PBG  A 360 (-3.4A)
None
 1.49A 4dmgA-3obkA:
undetectable		 4dmgA-3obkA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DMG_B_SAMB401_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493)		 3obk DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Toxoplasma
gondii) 		5 / 11 ARG A 189
GLU A 107
ALA A 105
ASP A 146
PRO A 139
 MG  A 365 ( 4.7A)
None
None
PBG  A 360 (-3.4A)
None
 1.42A 4dmgB-3obkA:
0.0		 4dmgB-3obkA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3obk DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Toxoplasma
gondii) 		4 / 8 ASP A 242
LYS A 237
ALA A 215
SER A 244
 None
 0.98A 4k0bB-3obkA:
undetectable		 4k0bB-3obkA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3obk DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Toxoplasma
gondii) 		4 / 8 ASP A 242
LYS A 237
ALA A 215
SER A 244
 None
 0.95A 4l7iB-3obkA:
undetectable		 4l7iB-3obkA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3obk DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Toxoplasma
gondii) 		4 / 5 TYR A 296
LEU A 318
GLU A 336
VAL A 342
 None
 1.32A 4nkvA-3obkA:
undetectable		 4nkvA-3obkA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 3obk DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Toxoplasma
gondii) 		3 / 3 ARG A 189
ASP A 184
TYR A 210
 MG  A 365 ( 4.7A)
None
None
 0.93A 4yo9B-3obkA:
undetectable		 4yo9B-3obkA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 3obk DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Toxoplasma
gondii) 		5 / 12 THR A 171
LEU A 165
PRO A 116
ALA A 133
ILE A 119
 None
 1.44A 5ewjC-3obkA:
undetectable
5ewjD-3obkA:
undetectable		 5ewjC-3obkA:
22.81
5ewjD-3obkA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 3obk DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Toxoplasma
gondii) 		3 / 3 ILE A 193
MET A 265
ASP A 184
 None
 0.66A 5h2uA-3obkA:
undetectable		 5h2uA-3obkA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3obk DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Toxoplasma
gondii) 		3 / 3 LYS A 213
LEU A 208
ASP A 134
 PBG  A 360 (-2.8A)
None
PBG  A 360 (-3.8A)
 0.92A 5zv2A-3obkA:
undetectable		 5zv2A-3obkA:
13.75