SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3obw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3obw PROTEIN PELOTA
HOMOLOG
(Sulfolobus
solfataricus) 		4 / 7 LEU A  97
ILE A  75
ALA A  38
ILE A 106
 None
 0.84A 1oniB-3obwA:
undetectable
1oniC-3obwA:
undetectable		 1oniB-3obwA:
18.89
1oniC-3obwA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 3obw PROTEIN PELOTA
HOMOLOG
(Sulfolobus
solfataricus) 		4 / 7 LEU A 286
GLU A 315
LYS A 254
ALA A 255
 None
 1.10A 1sn0B-3obwA:
undetectable
1sn0D-3obwA:
undetectable		 1sn0B-3obwA:
17.54
1sn0D-3obwA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3obw PROTEIN PELOTA
HOMOLOG
(Sulfolobus
solfataricus) 		4 / 5 LEU A 286
PRO A 320
VAL A 319
ILE A 317
 None
 0.98A 2aoiB-3obwA:
undetectable		 2aoiB-3obwA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3obw PROTEIN PELOTA
HOMOLOG
(Sulfolobus
solfataricus) 		4 / 5 SER A 221
GLY A 226
HIS A  93
ASP A  81
 None
 1.14A 2oxtB-3obwA:
undetectable		 2oxtB-3obwA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 3obw PROTEIN PELOTA
HOMOLOG
(Sulfolobus
solfataricus) 		5 / 12 GLY A 226
PRO A 194
GLY A 193
ILE A 104
ALA A 225
 None
 1.11A 2plwA-3obwA:
undetectable		 2plwA-3obwA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 3obw PROTEIN PELOTA
HOMOLOG
(Sulfolobus
solfataricus) 		4 / 6 VAL A  13
GLY A 226
ARG A 224
LEU A 139
 None
 1.02A 3bjwE-3obwA:
undetectable		 3bjwE-3obwA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 3obw PROTEIN PELOTA
HOMOLOG
(Sulfolobus
solfataricus) 		5 / 12 GLU A 278
VAL A 285
ASP A 308
ILE A 309
ASN A 311
 None
 1.38A 3jayA-3obwA:
undetectable		 3jayA-3obwA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 3obw PROTEIN PELOTA
HOMOLOG
(Sulfolobus
solfataricus) 		5 / 12 GLU A 278
VAL A 285
ASP A 308
ILE A 309
ASN A 311
 None
 1.37A 3jb3A-3obwA:
undetectable		 3jb3A-3obwA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 3obw PROTEIN PELOTA
HOMOLOG
(Sulfolobus
solfataricus) 		4 / 5 VAL A 287
LEU A 291
ILE A 302
VAL A 273
 None
 0.91A 4a9kB-3obwA:
undetectable		 4a9kB-3obwA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTV_A_ADNA403_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3obw PROTEIN PELOTA
HOMOLOG
(Sulfolobus
solfataricus) 		5 / 12 ASP A 242
SER A 126
ASP A 237
ILE A 235
ILE A 128
 None
 1.45A 4ktvA-3obwA:
undetectable
4ktvB-3obwA:
undetectable		 4ktvA-3obwA:
23.80
4ktvB-3obwA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 3obw PROTEIN PELOTA
HOMOLOG
(Sulfolobus
solfataricus) 		4 / 5 THR A 223
THR A  40
HIS A  93
LEU A  59
 None
 1.22A 4lvcA-3obwA:
undetectable		 4lvcA-3obwA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 3obw PROTEIN PELOTA
HOMOLOG
(Sulfolobus
solfataricus) 		4 / 5 THR A 223
THR A  40
HIS A  93
LEU A  59
 None
 1.21A 4lvcC-3obwA:
undetectable		 4lvcC-3obwA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 3obw PROTEIN PELOTA
HOMOLOG
(Sulfolobus
solfataricus) 		5 / 12 ALA A 222
GLU A 229
ILE A 104
GLU A  80
ALA A  12
 None
 1.00A 5n5dB-3obwA:
undetectable		 5n5dB-3obwA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 3obw PROTEIN PELOTA
HOMOLOG
(Sulfolobus
solfataricus) 		5 / 12 LEU A 190
LEU A 191
LEU A 132
ILE A 236
LEU A 227
 None
 1.06A 5toaA-3obwA:
undetectable		 5toaA-3obwA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 3obw PROTEIN PELOTA
HOMOLOG
(Sulfolobus
solfataricus) 		4 / 5 THR A 223
THR A  40
HIS A  93
LEU A  59
 None
 1.23A 6gbnA-3obwA:
undetectable		 6gbnA-3obwA:
24.84