SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3oby'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 3oby PROTEIN PELOTA
HOMOLOG
(Archaeoglobus
fulgidus) 		5 / 10 GLU A 272
ALA A 336
LEU A 256
ALA A 335
GLY A 333
 None
 1.19A 1mjqG-3obyA:
undetectable
1mjqH-3obyA:
undetectable		 1mjqG-3obyA:
14.70
1mjqH-3obyA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZEA_A_DHIA6_0
(MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN
MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
L CHAIN
SHORT SYNTHETIC
D-AMINO ACID PEPTIDE
D2)		 3oby PROTEIN PELOTA
HOMOLOG
(Archaeoglobus
fulgidus) 		3 / 3 TRP A  26
ARG A  29
PHE A  72
 None
 1.21A 1zeaH-3obyA:
undetectable
1zeaL-3obyA:
undetectable		 1zeaH-3obyA:
20.22
1zeaL-3obyA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_D_BEZD194_0
(PUTATIVE KINASE)		 3oby PROTEIN PELOTA
HOMOLOG
(Archaeoglobus
fulgidus) 		4 / 5 PRO A 324
ILE A 253
ARG A 327
ASP A 254
 None
 1.41A 2rhmD-3obyA:
undetectable		 2rhmD-3obyA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 3oby PROTEIN PELOTA
HOMOLOG
(Archaeoglobus
fulgidus) 		4 / 5 LEU A 232
ILE A 189
ILE A 229
GLY A 150
 None
 0.80A 3bufA-3obyA:
undetectable		 3bufA-3obyA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 3oby PROTEIN PELOTA
HOMOLOG
(Archaeoglobus
fulgidus) 		4 / 7 ALA A 191
GLY A 192
GLY A 227
ILE A 231
 None
 0.68A 4eatA-3obyA:
undetectable		 4eatA-3obyA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 3oby PROTEIN PELOTA
HOMOLOG
(Archaeoglobus
fulgidus) 		5 / 11 ALA A 336
VAL A 301
ASP A 302
GLY A 333
PHE A 291
 None
 1.12A 4xp4A-3obyA:
undetectable		 4xp4A-3obyA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 3oby PROTEIN PELOTA
HOMOLOG
(Archaeoglobus
fulgidus) 		4 / 7 THR A  21
LEU A 286
VAL A 308
GLU A 295
 None
 1.02A 5tudA-3obyA:
undetectable		 5tudA-3obyA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNU_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3oby PROTEIN PELOTA
HOMOLOG
(Archaeoglobus
fulgidus) 		4 / 7 PHE A  72
GLU A 297
ARG A  29
VAL A 301
 None
 1.49A 5unuA-3obyA:
undetectable
5unuB-3obyA:
undetectable		 5unuA-3obyA:
22.08
5unuB-3obyA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 3oby PROTEIN PELOTA
HOMOLOG
(Archaeoglobus
fulgidus) 		5 / 10 LEU A 286
VAL A 287
GLU A 309
VAL A 308
ILE A 282
 None
 0.89A 5v02B-3obyA:
undetectable
5v02R-3obyA:
undetectable		 5v02B-3obyA:
15.86
5v02R-3obyA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 3oby PROTEIN PELOTA
HOMOLOG
(Archaeoglobus
fulgidus) 		5 / 12 PHE A 155
PHE A 172
PHE A 183
ALA A 196
ILE A 189
 None
 1.20A 6aybA-3obyA:
undetectable		 6aybA-3obyA:
23.40