SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3oc4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_A_SAMA500_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)		 3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY
(Enterococcus
faecalis) 		5 / 12 PRO A 242
PHE A  10
GLY A 276
THR A 109
ASN A 297
 None
FAD  A 500 (-4.6A)
FAD  A 500 (-3.5A)
FAD  A 500 (-3.6A)
None
 1.35A 1g60A-3oc4A:
undetectable		 1g60A-3oc4A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		 3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY
(Enterococcus
faecalis) 		5 / 12 LEU A 431
ASN A 430
GLY A 433
VAL A 380
LEU A 385
 None
 1.39A 1nhzA-3oc4A:
undetectable		 1nhzA-3oc4A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY
(Enterococcus
faecalis) 		4 / 6 ALA A 108
TYR A 246
ILE A 106
ILE A   6
 None
FAD  A 500 (-4.5A)
None
None
 1.21A 2dcfA-3oc4A:
undetectable		 2dcfA-3oc4A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY
(Enterococcus
faecalis) 		5 / 11 GLY A   7
SER A   9
THR A 109
GLY A 110
PHE A 131
 FAD  A 500 (-3.2A)
FAD  A 500 (-2.5A)
FAD  A 500 (-3.6A)
FAD  A 500 (-3.3A)
None
 1.39A 2hmaA-3oc4A:
undetectable		 2hmaA-3oc4A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY
(Enterococcus
faecalis) 		5 / 9 LEU A 107
ILE A 275
ILE A 279
VAL A 261
THR A 267
 None
 1.16A 2m9qA-3oc4A:
undetectable		 2m9qA-3oc4A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY
(Enterococcus
faecalis) 		5 / 10 ALA A  15
ALA A  16
VAL A 261
ILE A 259
CYH A 278
 None
 0.92A 3falA-3oc4A:
undetectable		 3falA-3oc4A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY
(Enterococcus
faecalis) 		3 / 3 SER A   9
ASP A  32
ASP A 277
 FAD  A 500 (-2.5A)
FAD  A 500 (-2.9A)
FAD  A 500 (-3.0A)
 0.71A 3iv6A-3oc4A:
2.9		 3iv6A-3oc4A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY
(Enterococcus
faecalis) 		3 / 3 SER A   9
ASP A  32
ASP A 277
 FAD  A 500 (-2.5A)
FAD  A 500 (-2.9A)
FAD  A 500 (-3.0A)
 0.75A 3iv6C-3oc4A:
undetectable		 3iv6C-3oc4A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY
(Enterococcus
faecalis) 		4 / 6 LEU A 244
VAL A 304
VAL A 261
ILE A 106
 None
 1.26A 3k5vB-3oc4A:
undetectable		 3k5vB-3oc4A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY
(Enterococcus
faecalis) 		6 / 12 VAL A 305
GLY A  12
SER A  14
ALA A  18
TYR A 246
LEU A 107
 None
None
None
None
FAD  A 500 (-4.5A)
None
 1.22A 3mb5A-3oc4A:
4.4		 3mb5A-3oc4A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY
(Enterococcus
faecalis) 		4 / 7 ALA A 274
VAL A 269
VAL A 272
LEU A 107
 None
 0.65A 3o14A-3oc4A:
undetectable		 3o14A-3oc4A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY
(Enterococcus
faecalis) 		3 / 3 ALA A 287
VAL A 286
GLN A 347
 None
 0.54A 3of4B-3oc4A:
undetectable		 3of4B-3oc4A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		 3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY
(Enterococcus
faecalis) 		5 / 12 LEU A  -1
LEU A 309
ASN A 307
ALA A  15
ILE A 106
 None
 1.14A 3ut5B-3oc4A:
undetectable		 3ut5B-3oc4A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY
(Enterococcus
faecalis) 		5 / 12 LEU A  -1
LEU A 309
ASN A 307
ALA A  15
ILE A 106
 None
 1.14A 3ut5D-3oc4A:
undetectable		 3ut5D-3oc4A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BCS_A_ACTA1126_0
(CHIMERIC AVIDIN)		 3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY
(Enterococcus
faecalis) 		4 / 4 THR A 404
GLN A 406
ARG A 379
THR A 407
 None
 1.33A 4bcsA-3oc4A:
0.0		 4bcsA-3oc4A:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY
(Enterococcus
faecalis) 		4 / 5 LEU A 244
LEU A 107
MET A  82
THR A 267
 None
 1.49A 4do3A-3oc4A:
undetectable		 4do3A-3oc4A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY
(Enterococcus
faecalis) 		3 / 3 PHE A  10
VAL A 281
ILE A 279
 FAD  A 500 (-4.6A)
None
None
 0.60A 4emaA-3oc4A:
undetectable		 4emaA-3oc4A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY
(Enterococcus
faecalis) 		4 / 8 LEU A 181
ALA A 153
LEU A 180
VAL A 150
 None
 0.96A 4ik6B-3oc4A:
undetectable		 4ik6B-3oc4A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY
(Enterococcus
faecalis) 		5 / 12 GLY A 152
LEU A 177
THR A 116
ILE A 118
PHE A 236
 None
 1.39A 4p6xA-3oc4A:
undetectable		 4p6xA-3oc4A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY
(Enterococcus
faecalis) 		5 / 12 GLY A 152
LEU A 177
THR A 116
ILE A 118
PHE A 236
 None
 1.35A 4p6xE-3oc4A:
undetectable		 4p6xE-3oc4A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_1
(GLUCOCORTICOID
RECEPTOR)		 3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY
(Enterococcus
faecalis) 		5 / 12 GLY A 152
LEU A 177
THR A 116
ILE A 118
PHE A 236
 None
 1.34A 4p6xG-3oc4A:
undetectable		 4p6xG-3oc4A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY
(Enterococcus
faecalis) 		5 / 12 GLY A 152
LEU A 177
THR A 116
ILE A 118
PHE A 236
 None
 1.32A 4p6xI-3oc4A:
undetectable		 4p6xI-3oc4A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY
(Enterococcus
faecalis) 		5 / 12 SER A 435
GLY A 433
ILE A 395
GLY A 382
GLU A 339
 None
 1.04A 4r29D-3oc4A:
undetectable		 4r29D-3oc4A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY
(Enterococcus
faecalis) 		5 / 12 LEU A  -1
LEU A 309
ASN A 307
ALA A  15
ILE A 106
 None
 1.06A 4x1yB-3oc4A:
undetectable		 4x1yB-3oc4A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY
(Enterococcus
faecalis) 		5 / 11 LEU A  -1
LEU A 309
ASN A 307
ALA A  15
ILE A 106
 None
 1.18A 4x20D-3oc4A:
undetectable		 4x20D-3oc4A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY
(Enterococcus
faecalis) 		5 / 11 VAL A 165
PHE A 204
PHE A 206
GLY A 157
GLY A 154
 None
 1.27A 4zvmA-3oc4A:
undetectable
4zvmB-3oc4A:
undetectable		 4zvmA-3oc4A:
19.04
4zvmB-3oc4A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY
(Enterococcus
faecalis) 		4 / 8 LEU A  30
GLY A  12
ALA A  11
SER A  14
 None
None
FAD  A 500 (-3.3A)
None
 0.76A 5f1aA-3oc4A:
undetectable		 5f1aA-3oc4A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY
(Enterococcus
faecalis) 		4 / 7 LEU A  30
GLY A  12
ALA A  11
SER A  14
 None
None
FAD  A 500 (-3.3A)
None
 0.77A 5f1aB-3oc4A:
undetectable		 5f1aB-3oc4A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY
(Enterococcus
faecalis) 		3 / 3 VAL A 193
GLN A 384
CYH A 386
 None
 0.83A 5icxA-3oc4A:
undetectable
5icxE-3oc4A:
undetectable		 5icxA-3oc4A:
18.99
5icxE-3oc4A:
2.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY
(Enterococcus
faecalis) 		3 / 3 VAL A 193
GLN A 384
CYH A 386
 None
 0.87A 5icxC-3oc4A:
undetectable
5icxF-3oc4A:
undetectable		 5icxC-3oc4A:
18.99
5icxF-3oc4A:
2.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)		 3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY
(Enterococcus
faecalis) 		6 / 12 LEU A  -1
LEU A 309
ASN A 307
ALA A  15
ILE A  28
ILE A 106
 None
 1.32A 5itzB-3oc4A:
undetectable		 5itzB-3oc4A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY
(Enterococcus
faecalis) 		4 / 8 LEU A 105
VAL A 272
MET A  82
TYR A 246
 None
None
None
FAD  A 500 (-4.5A)
 1.01A 5nu7A-3oc4A:
undetectable		 5nu7A-3oc4A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY
(Enterococcus
faecalis) 		6 / 12 LEU A  -1
LEU A 309
ASN A 307
ALA A  15
ILE A  28
ILE A 106
 None
 1.28A 5xiwB-3oc4A:
undetectable		 5xiwB-3oc4A:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY
(Enterococcus
faecalis) 		4 / 5 VAL A 269
PHE A 290
MET A 282
GLY A 318
 None
 1.36A 6hd4A-3oc4A:
undetectable		 6hd4A-3oc4A:
10.84