SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3odw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		3 / 3 MET A 634
LEU A 635
SER A 636
 None
 0.62A 1ee2A-3odwA:
undetectable		 1ee2A-3odwA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		4 / 4 THR A 655
LEU A 654
VAL A 668
LEU A 670
 None
 0.97A 1fbmD-3odwA:
undetectable		 1fbmD-3odwA:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		4 / 4 THR A 655
LEU A 654
VAL A 668
LEU A 670
 None
 0.96A 1mz9D-3odwA:
undetectable		 1mz9D-3odwA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_E_ACTE1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		5 / 10 ILE A 421
GLU A 490
ILE A 489
GLU A 584
ILE A 492
 None
 1.30A 2j9dD-3odwA:
undetectable
2j9dE-3odwA:
undetectable
2j9dF-3odwA:
undetectable		 2j9dD-3odwA:
11.94
2j9dE-3odwA:
11.94
2j9dF-3odwA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		4 / 8 SER A 512
PHE A 508
VAL A 602
LEU A 599
 None
 0.94A 3ax7A-3odwA:
undetectable		 3ax7A-3odwA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		4 / 6 MET A 562
LEU A 565
PRO A 569
TYR A 568
 None
 1.18A 3vkxA-3odwA:
undetectable		 3vkxA-3odwA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		4 / 7 GLU A 428
TYR A 568
VAL A 588
PHE A 474
 None
 1.06A 4a97H-3odwA:
undetectable		 4a97H-3odwA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		4 / 8 ARG A 596
GLU A 593
GLU A 589
ARG A 585
 None
 1.20A 4bqfB-3odwA:
undetectable		 4bqfB-3odwA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		4 / 8 LEU A 740
VAL A 668
VAL A 666
GLN A 679
 None
 0.95A 4em2A-3odwA:
undetectable		 4em2A-3odwA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		4 / 6 VAL A 649
SER A 761
ALA A 713
PHE A 729
 None
 1.07A 4nedA-3odwA:
undetectable		 4nedA-3odwA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		4 / 6 GLU A 428
TYR A 568
LEU A 572
PHE A 474
 None
 0.98A 4twdB-3odwA:
undetectable
4twdC-3odwA:
2.3		 4twdB-3odwA:
20.11
4twdC-3odwA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		4 / 6 GLU A 428
TYR A 568
LEU A 572
PHE A 474
 None
 1.06A 4twdD-3odwA:
4.1
4twdE-3odwA:
4.1		 4twdD-3odwA:
20.11
4twdE-3odwA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		4 / 7 GLU A 428
TYR A 568
LEU A 572
PHE A 474
 None
 1.13A 4twdF-3odwA:
1.8
4twdJ-3odwA:
undetectable		 4twdF-3odwA:
20.11
4twdJ-3odwA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		3 / 3 ASP A 440
GLU A 448
SER A 472
 None
 0.86A 5bw4B-3odwA:
undetectable		 5bw4B-3odwA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		3 / 3 MET A 479
GLN A 483
ARG A 482
 None
 1.02A 5ewzB-3odwA:
2.5		 5ewzB-3odwA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		4 / 5 GLU A 581
THR A 579
GLU A 589
LEU A 497
 None
 1.14A 5hm8A-3odwA:
undetectable		 5hm8A-3odwA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		4 / 5 GLU A 581
THR A 579
GLU A 589
LEU A 497
 None
 1.14A 5hm8B-3odwA:
undetectable		 5hm8B-3odwA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		4 / 5 GLU A 581
THR A 579
GLU A 589
LEU A 497
 None
 1.14A 5hm8C-3odwA:
undetectable		 5hm8C-3odwA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		4 / 5 GLU A 581
THR A 579
GLU A 589
LEU A 497
 None
 1.14A 5hm8D-3odwA:
undetectable		 5hm8D-3odwA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		4 / 5 GLU A 581
THR A 579
GLU A 589
LEU A 497
 None
 1.14A 5hm8E-3odwA:
undetectable		 5hm8E-3odwA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		4 / 5 GLU A 581
THR A 579
GLU A 589
LEU A 497
 None
 1.14A 5hm8F-3odwA:
undetectable		 5hm8F-3odwA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		4 / 5 GLU A 581
THR A 579
GLU A 589
LEU A 497
 None
 1.17A 5hm8G-3odwA:
undetectable		 5hm8G-3odwA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		4 / 5 GLU A 581
THR A 579
GLU A 589
LEU A 497
 None
 1.14A 5hm8H-3odwA:
undetectable		 5hm8H-3odwA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		3 / 3 ARG A 514
PRO A 462
ASN A 459
 None
 0.99A 5jwaA-3odwA:
undetectable
5jwaH-3odwA:
undetectable		 5jwaA-3odwA:
20.66
5jwaH-3odwA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KSN_A_NIZA809_1
(CATALASE-PEROXIDASE)		 3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		5 / 9 GLU A 757
VAL A 649
GLY A 760
SER A 761
LEU A 762
 None
 1.46A 5ksnA-3odwA:
1.2		 5ksnA-3odwA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KSN_B_NIZB809_1
(CATALASE-PEROXIDASE)		 3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		5 / 9 GLU A 757
VAL A 649
GLY A 760
SER A 761
LEU A 762
 None
 1.47A 5ksnB-3odwA:
1.1		 5ksnB-3odwA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KT8_B_NIZB809_1
(CATALASE-PEROXIDASE)		 3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		5 / 9 GLU A 757
VAL A 649
GLY A 760
SER A 761
LEU A 762
 None
 1.47A 5kt8B-3odwA:
undetectable		 5kt8B-3odwA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		3 / 3 MET A 479
GLN A 483
ARG A 482
 None
 1.03A 5m35B-3odwA:
2.6		 5m35B-3odwA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		3 / 3 MET A 479
GLN A 483
ARG A 482
 None
 1.00A 5m36A-3odwA:
2.6		 5m36A-3odwA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXS_B_NIZB806_1
(CATALASE-PEROXIDASE)		 3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		5 / 9 GLU A 757
VAL A 649
GLY A 760
SER A 761
LEU A 762
 None
 1.47A 5sxsB-3odwA:
undetectable		 5sxsB-3odwA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYI_B_NIZB805_1
(CATALASE-PEROXIDASE)		 3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		5 / 9 GLU A 757
VAL A 649
GLY A 760
SER A 761
LEU A 762
 None
 1.46A 5syiB-3odwA:
undetectable		 5syiB-3odwA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDQ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		5 / 9 GLU A 757
VAL A 649
GLY A 760
SER A 761
LEU A 762
 None
 1.44A 6cdqA-3odwA:
undetectable		 6cdqA-3odwA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CFQ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		5 / 9 GLU A 757
VAL A 649
GLY A 760
SER A 761
LEU A 762
 None
 1.45A 6cfqB-3odwA:
undetectable		 6cfqB-3odwA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		3 / 3 MET A 479
GLN A 483
ARG A 482
 None
 1.01A 6fn9A-3odwA:
2.3		 6fn9A-3odwA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		3 / 3 MET A 479
GLN A 483
ARG A 482
 None
 1.05A 6fnaB-3odwA:
2.1		 6fnaB-3odwA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		3 / 3 MET A 479
GLN A 483
ARG A 482
 None
 1.01A 6fnbA-3odwA:
2.2		 6fnbA-3odwA:
19.83