SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3odx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 3odx RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		3 / 3 LYS A 749
VAL A 745
HIS A 722
 None
 1.23A 3tj7A-3odxA:
undetectable		 3tj7A-3odxA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 3odx RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		4 / 6 MET A 562
LEU A 565
PRO A 569
TYR A 568
 None
 1.17A 3vkxA-3odxA:
undetectable		 3vkxA-3odxA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 3odx RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		4 / 5 LEU A 571
HIS A 431
GLU A 428
HIS A 471
 None
 1.38A 4a7bB-3odxA:
undetectable		 4a7bB-3odxA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 3odx RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		4 / 8 ARG A 596
GLU A 593
GLU A 589
ARG A 585
 None
 1.18A 4bqfB-3odxA:
undetectable		 4bqfB-3odxA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3odx RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		5 / 11 LEU A 641
PHE A 638
LEU A 687
ARG A 709
VAL A 666
 None
 1.39A 4mk4B-3odxA:
undetectable		 4mk4B-3odxA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 3odx RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		4 / 6 VAL A 649
SER A 761
ALA A 713
PHE A 729
 None
 1.06A 4nedA-3odxA:
undetectable		 4nedA-3odxA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3odx RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		4 / 6 GLU A 428
TYR A 568
LEU A 572
PHE A 474
 None
 0.99A 4twdB-3odxA:
2.2
4twdC-3odxA:
2.2		 4twdB-3odxA:
20.05
4twdC-3odxA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3odx RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		4 / 6 GLU A 428
TYR A 568
LEU A 572
PHE A 474
 None
 1.06A 4twdD-3odxA:
4.1
4twdE-3odxA:
4.1		 4twdD-3odxA:
20.05
4twdE-3odxA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3odx RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		4 / 7 GLU A 428
TYR A 568
LEU A 572
PHE A 474
 None
 1.11A 4twdF-3odxA:
undetectable
4twdJ-3odxA:
undetectable		 4twdF-3odxA:
20.05
4twdJ-3odxA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3odx RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		4 / 7 GLU A 586
LYS A 587
LEU A 590
LEU A 497
 None
 0.65A 4wg0B-3odxA:
undetectable
4wg0C-3odxA:
undetectable		 4wg0B-3odxA:
4.15
4wg0C-3odxA:
4.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3odx RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		4 / 7 LEU A 497
GLU A 586
LYS A 587
LEU A 590
 None
 0.64A 4wg0L-3odxA:
undetectable
4wg0M-3odxA:
undetectable		 4wg0L-3odxA:
4.15
4wg0M-3odxA:
4.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3odx RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		3 / 3 MET A 479
GLN A 483
ARG A 482
 None
 1.01A 5ewzB-3odxA:
2.5		 5ewzB-3odxA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3odx RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		4 / 5 GLU A 581
THR A 579
GLU A 589
LEU A 497
 None
 1.12A 5hm8A-3odxA:
undetectable		 5hm8A-3odxA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3odx RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		4 / 5 GLU A 581
THR A 579
GLU A 589
LEU A 497
 None
 1.13A 5hm8B-3odxA:
undetectable		 5hm8B-3odxA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3odx RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		4 / 5 GLU A 581
THR A 579
GLU A 589
LEU A 497
 None
 1.12A 5hm8C-3odxA:
undetectable		 5hm8C-3odxA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3odx RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		4 / 5 GLU A 581
THR A 579
GLU A 589
LEU A 497
 None
 1.13A 5hm8D-3odxA:
undetectable		 5hm8D-3odxA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3odx RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		4 / 5 GLU A 581
THR A 579
GLU A 589
LEU A 497
 None
 1.13A 5hm8E-3odxA:
undetectable		 5hm8E-3odxA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3odx RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		4 / 5 GLU A 581
THR A 579
GLU A 589
LEU A 497
 None
 1.12A 5hm8F-3odxA:
undetectable		 5hm8F-3odxA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3odx RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		4 / 5 GLU A 581
THR A 579
GLU A 589
LEU A 497
 None
 1.15A 5hm8G-3odxA:
undetectable		 5hm8G-3odxA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3odx RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		4 / 5 GLU A 581
THR A 579
GLU A 589
LEU A 497
 None
 1.13A 5hm8H-3odxA:
undetectable		 5hm8H-3odxA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3odx RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		5 / 12 ILE A 575
GLY A 576
GLU A 428
ARG A 481
PHE A 500
 None
 1.17A 5igwA-3odxA:
undetectable		 5igwA-3odxA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 3odx RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		3 / 3 ARG A 514
PRO A 462
ASN A 459
 None
 1.01A 5jwaA-3odxA:
undetectable
5jwaH-3odxA:
undetectable		 5jwaA-3odxA:
18.59
5jwaH-3odxA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3odx RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		3 / 3 MET A 479
GLN A 483
ARG A 482
 None
 0.98A 5m35B-3odxA:
2.6		 5m35B-3odxA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3odx RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		3 / 3 MET A 479
GLN A 483
ARG A 482
 None
 0.94A 5m36A-3odxA:
2.6		 5m36A-3odxA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 3odx RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		4 / 7 LEU A 424
ARG A 499
GLU A 561
SER A 512
 None
 1.26A 5umwA-3odxA:
undetectable
5umwF-3odxA:
undetectable		 5umwA-3odxA:
11.31
5umwF-3odxA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3odx RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		3 / 3 MET A 479
GLN A 483
ARG A 482
 None
 0.95A 6fn9A-3odxA:
2.3		 6fn9A-3odxA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3odx RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		3 / 3 MET A 479
GLN A 483
ARG A 482
 None
 1.00A 6fnaB-3odxA:
2.1		 6fnaB-3odxA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3odx RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens) 		3 / 3 MET A 479
GLN A 483
ARG A 482
 None
 0.95A 6fnbA-3odxA:
2.2		 6fnbA-3odxA:
22.58