SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3oec'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3oec CARVEOL
DEHYDROGENASE
(MYTHA.01326.C,
A0R518 HOMOLOG)
(Mycolicibacteriu
m
thermoresistibil
e) 		3 / 3 ASN A 220
TRP A 259
GLN A  36
 None
 1.25A 1xoqA-3oecA:
undetectable		 1xoqA-3oecA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_1
(POL PROTEIN)		 3oec CARVEOL
DEHYDROGENASE
(MYTHA.01326.C,
A0R518 HOMOLOG)
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 11 GLY A 147
ALA A 148
GLY A 122
ILE A 123
VAL A 193
 None
 0.84A 2fxdA-3oecA:
undetectable		 2fxdA-3oecA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_1
(PROTEASE)		 3oec CARVEOL
DEHYDROGENASE
(MYTHA.01326.C,
A0R518 HOMOLOG)
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 GLY A 147
ALA A 148
GLY A 122
ILE A 123
VAL A 193
 None
 0.93A 3el4A-3oecA:
undetectable		 3el4A-3oecA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_2
(PROTEASE)		 3oec CARVEOL
DEHYDROGENASE
(MYTHA.01326.C,
A0R518 HOMOLOG)
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 GLY A 147
ALA A 148
GLY A 122
ILE A 123
VAL A 193
 None
 0.92A 3el5B-3oecA:
undetectable		 3el5B-3oecA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_1
(PROTEASE)		 3oec CARVEOL
DEHYDROGENASE
(MYTHA.01326.C,
A0R518 HOMOLOG)
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 GLY A 147
ALA A 148
GLY A 122
ILE A 123
VAL A 193
 None
 0.94A 3gguA-3oecA:
undetectable		 3gguA-3oecA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 3oec CARVEOL
DEHYDROGENASE
(MYTHA.01326.C,
A0R518 HOMOLOG)
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 ILE A 169
ALA A 273
ALA A  49
ILE A  51
HIS A  40
 None
 1.07A 3gwsX-3oecA:
undetectable		 3gwsX-3oecA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_2
(PROTEASE)		 3oec CARVEOL
DEHYDROGENASE
(MYTHA.01326.C,
A0R518 HOMOLOG)
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 10 GLY A 147
ALA A 148
GLY A 122
ILE A 123
VAL A 193
 None
 0.85A 3nu9B-3oecA:
undetectable		 3nu9B-3oecA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 3oec CARVEOL
DEHYDROGENASE
(MYTHA.01326.C,
A0R518 HOMOLOG)
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 7 ASN A  62
PRO A  61
ARG A  58
ARG A  95
 None
 1.04A 3twpC-3oecA:
3.7		 3twpC-3oecA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_1
(POL POLYPROTEIN)		 3oec CARVEOL
DEHYDROGENASE
(MYTHA.01326.C,
A0R518 HOMOLOG)
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 9 GLY A 147
ALA A 148
GLY A 122
ILE A 123
VAL A 193
 None
 0.96A 3u7sA-3oecA:
undetectable		 3u7sA-3oecA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 3oec CARVEOL
DEHYDROGENASE
(MYTHA.01326.C,
A0R518 HOMOLOG)
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 9 GLY A 147
ALA A 148
GLY A 122
ILE A 123
VAL A 193
 None
 1.01A 3u7sB-3oecA:
undetectable		 3u7sB-3oecA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 3oec CARVEOL
DEHYDROGENASE
(MYTHA.01326.C,
A0R518 HOMOLOG)
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 GLY A 147
ALA A 148
GLY A 122
ILE A 123
VAL A 193
 None
 0.92A 3ucbA-3oecA:
undetectable		 3ucbA-3oecA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 3oec CARVEOL
DEHYDROGENASE
(MYTHA.01326.C,
A0R518 HOMOLOG)
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 5 ILE A 116
ALA A  49
HIS A  40
ARG A  43
 None
 0.79A 4ac9B-3oecA:
4.7
4ac9C-3oecA:
6.4		 4ac9B-3oecA:
22.04
4ac9C-3oecA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3oec CARVEOL
DEHYDROGENASE
(MYTHA.01326.C,
A0R518 HOMOLOG)
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 5 ILE A 116
ALA A  49
HIS A  40
ARG A  43
 None
 0.81A 4acaB-3oecA:
5.8
4acaC-3oecA:
6.3		 4acaB-3oecA:
22.04
4acaC-3oecA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 3oec CARVEOL
DEHYDROGENASE
(MYTHA.01326.C,
A0R518 HOMOLOG)
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 7 SER A 173
GLN A 183
TYR A 186
MET A 223
 None
 0.84A 4hxyB-3oecA:
19.5		 4hxyB-3oecA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3oec CARVEOL
DEHYDROGENASE
(MYTHA.01326.C,
A0R518 HOMOLOG)
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 8 PRO A 216
VAL A 265
VAL A 175
GLY A 176
 None
 0.64A 4mk4A-3oecA:
3.0		 4mk4A-3oecA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 3oec CARVEOL
DEHYDROGENASE
(MYTHA.01326.C,
A0R518 HOMOLOG)
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 6 GLU A  82
GLY A  31
ASP A  55
GLY A  37
 None
 0.92A 5cdpA-3oecA:
undetectable
5cdpB-3oecA:
3.2		 5cdpA-3oecA:
23.16
5cdpB-3oecA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3oec CARVEOL
DEHYDROGENASE
(MYTHA.01326.C,
A0R518 HOMOLOG)
(Mycolicibacteriu
m
thermoresistibil
e) 		3 / 3 ASN A  62
PRO A  61
GLN A  59
 None
 0.80A 6jnhA-3oecA:
3.8		 6jnhA-3oecA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3oec CARVEOL
DEHYDROGENASE
(MYTHA.01326.C,
A0R518 HOMOLOG)
(Mycolicibacteriu
m
thermoresistibil
e) 		3 / 3 ASN A  62
PRO A  61
GLN A  59
 None
 0.82A 6jogA-3oecA:
3.9		 6jogA-3oecA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NQA_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3oec CARVEOL
DEHYDROGENASE
(MYTHA.01326.C,
A0R518 HOMOLOG)
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 10 GLY A 182
GLY A 127
GLN A 136
GLU A 128
PHE A 233
 None
 1.13A 6nqaK-3oecA:
undetectable		 6nqaK-3oecA:
21.24