SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3oes'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 3oes GTPASE RHEBL1
(Homo
sapiens) 		3 / 3 PHE A  31
LEU A  22
SER A 149
 GNP  A 201 (-4.3A)
None
GNP  A 201 (-3.6A)
 0.70A 1e7aA-3oesA:
undetectable		 1e7aA-3oesA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 3oes GTPASE RHEBL1
(Homo
sapiens) 		3 / 3 ASN A  41
TYR A  35
SER A  21
 None
GNP  A 201 (-4.5A)
GNP  A 201 (-2.6A)
 0.94A 2gvcB-3oesA:
undetectable		 2gvcB-3oesA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 3oes GTPASE RHEBL1
(Homo
sapiens) 		4 / 4 LEU A  58
THR A  42
ILE A  46
HIS A  55
 None
 1.30A 2jfaB-3oesA:
undetectable		 2jfaB-3oesA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 3oes GTPASE RHEBL1
(Homo
sapiens) 		5 / 12 LEU A 103
ILE A  96
ILE A 159
VAL A   9
VAL A  78
 None
 1.08A 2ygoA-3oesA:
undetectable		 2ygoA-3oesA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_B_DXCB92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3oes GTPASE RHEBL1
(Homo
sapiens) 		4 / 5 VAL A  87
VAL A 129
ARG A 127
LYS A 136
 None
 1.45A 3rv5A-3oesA:
undetectable
3rv5B-3oesA:
undetectable		 3rv5A-3oesA:
18.91
3rv5B-3oesA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 3oes GTPASE RHEBL1
(Homo
sapiens) 		4 / 5 THR A  20
HIS A  24
ALA A  23
ASP A  60
 MG  A 202 ( 3.2A)
None
None
MG  A 202 ( 3.7A)
 1.25A 5mfxA-3oesA:
3.0		 5mfxA-3oesA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1S_B_SAMB604_0
(RADICAL SAM)		 3oes GTPASE RHEBL1
(Homo
sapiens) 		5 / 9 LEU A 123
GLU A 128
SER A  92
VAL A  84
SER A  21
 GNP  A 201 (-4.2A)
None
None
None
GNP  A 201 (-2.6A)
 1.49A 5v1sB-3oesA:
3.1		 5v1sB-3oesA:
21.81