SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3of1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RB2_B_FOLB161_0 (DIHYDROFOLATE REDUCTASE)	3of1	CAMP-DEPENDENT PROTEIN KINASE REGULATORY SUBUNIT (Saccharomyces cerevisiae)	5 / 12	ILE A 212 ALA A 260 PHE A 247 LEU A 270 ILE A 211	CMP A 501 (-4.5A) CMP A 501 (-3.5A) None None None	1.13A	1rb2B-3of1A: undetectable	1rb2B-3of1A: 18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OBW_A_SAMA602_1 (2-METHOXY-6-POLYPREN YL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL)	3of1	CAMP-DEPENDENT PROTEIN KINASE REGULATORY SUBUNIT (Saccharomyces cerevisiae)	3 / 3	ASP A 364 ASN A 411 SER A 299	None	0.66A	4obwA-3of1A: undetectable	4obwA-3of1A: 23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OLM_A_198A1001_2 (ANDROGEN RECEPTOR)	3of1	CAMP-DEPENDENT PROTEIN KINASE REGULATORY SUBUNIT (Saccharomyces cerevisiae)	4 / 6	MET A 300 ILE A 330 ILE A 329 VAL A 381	None CMP A 601 (-4.8A) None None	1.01A	4olmA-3of1A: undetectable	4olmA-3of1A: 21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Z6M_A_FOLA201_0 (DIHYDROFOLATE REDUCTASE)	3of1	CAMP-DEPENDENT PROTEIN KINASE REGULATORY SUBUNIT (Saccharomyces cerevisiae)	5 / 11	ILE A 212 ALA A 260 PHE A 247 LEU A 270 ILE A 211	CMP A 501 (-4.5A) CMP A 501 (-3.5A) None None None	1.02A	5z6mA-3of1A: undetectable	5z6mA-3of1A: 18.97

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1RB2_B_FOLB161_0","DIHYDROFOLATE REDUCTASE","3of1","CAMP-DEPENDENT PROTEIN KINASE REGULATORY SUBUNIT","Saccharomyces cerevisiae",5,"ILE A 212;ALA A 260;PHE A 247;LEU A 270;ILE A 211","CMP A 501 (-4.5A);CMP A 501 (-3.5A);None;None;None","1.13A","1rb2B-3of1A:undetectable","1rb2B-3of1A:18.43"],["4OBW_A_SAMA602_1","2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL","3of1","CAMP-DEPENDENT PROTEIN KINASE REGULATORY SUBUNIT","Saccharomyces cerevisiae",3,"ASP A 364;ASN A 411;SER A 299","None","0.66A","4obwA-3of1A:undetectable","4obwA-3of1A:23.38"],["4OLM_A_198A1001_2","ANDROGEN RECEPTOR","3of1","CAMP-DEPENDENT PROTEIN KINASE REGULATORY SUBUNIT","Saccharomyces cerevisiae",4,"MET A 300;ILE A 330;ILE A 329;VAL A 381","None;CMP A 601 (-4.8A);None;None","1.01A","4olmA-3of1A:undetectable","4olmA-3of1A:21.82"],["5Z6M_A_FOLA201_0","DIHYDROFOLATE REDUCTASE","3of1","CAMP-DEPENDENT PROTEIN KINASE REGULATORY SUBUNIT","Saccharomyces cerevisiae",5,"ILE A 212;ALA A 260;PHE A 247;LEU A 270;ILE A 211","CMP A 501 (-4.5A);CMP A 501 (-3.5A);None;None;None","1.02A","5z6mA-3of1A:undetectable","5z6mA-3of1A:18.97"]]