SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3of5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3of5 DETHIOBIOTIN
SYNTHETASE
(Francisella
tularensis) 		5 / 10 LEU A 218
SER A 215
PHE A   4
PHE A   5
ILE A   6
 None
 1.19A 1g5yC-3of5A:
undetectable		 1g5yC-3of5A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 3of5 DETHIOBIOTIN
SYNTHETASE
(Francisella
tularensis) 		4 / 7 LEU A 155
ASN A 159
GLU A 160
LEU A 119
 None
 1.24A 2w8yA-3of5A:
undetectable		 2w8yA-3of5A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		 3of5 DETHIOBIOTIN
SYNTHETASE
(Francisella
tularensis) 		4 / 8 PRO A  38
PHE A   5
PHE A  99
TYR A 104
 None
 1.46A 4v2zC-3of5A:
undetectable		 4v2zC-3of5A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3of5 DETHIOBIOTIN
SYNTHETASE
(Francisella
tularensis) 		4 / 4 LEU A 142
ILE A 172
GLY A   8
ILE A  18
 None
 0.71A 5dzk3-3of5A:
undetectable
5dzkm-3of5A:
undetectable		 5dzk3-3of5A:
1.63
5dzkm-3of5A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3of5 DETHIOBIOTIN
SYNTHETASE
(Francisella
tularensis) 		4 / 5 ILE A 172
GLY A   8
ILE A  18
LEU A 142
 None
 0.70A 5dzkB-3of5A:
undetectable
5dzkI-3of5A:
undetectable
5dzkW-3of5A:
undetectable		 5dzkB-3of5A:
20.51
5dzkI-3of5A:
20.75
5dzkW-3of5A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3of5 DETHIOBIOTIN
SYNTHETASE
(Francisella
tularensis) 		4 / 5 ILE A 172
GLY A   8
ILE A  18
LEU A 142
 None
 0.67A 5dzki-3of5A:
undetectable
5dzkj-3of5A:
undetectable
5dzkx-3of5A:
undetectable		 5dzki-3of5A:
20.75
5dzkj-3of5A:
20.75
5dzkx-3of5A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3of5 DETHIOBIOTIN
SYNTHETASE
(Francisella
tularensis) 		4 / 5 ILE A 172
GLY A   8
ILE A  18
LEU A 142
 None
 0.64A 5dzkd-3of5A:
undetectable
5dzkk-3of5A:
1.3
5dzky-3of5A:
undetectable		 5dzkd-3of5A:
20.51
5dzkk-3of5A:
20.75
5dzky-3of5A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3of5 DETHIOBIOTIN
SYNTHETASE
(Francisella
tularensis) 		4 / 4 ILE A 172
GLY A   8
ILE A  18
LEU A 142
 None
 0.70A 5dzkl-3of5A:
undetectable
5dzkz-3of5A:
undetectable		 5dzkl-3of5A:
20.75
5dzkz-3of5A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3of5 DETHIOBIOTIN
SYNTHETASE
(Francisella
tularensis) 		4 / 6 PRO A  80
HIS A 126
ALA A 135
LEU A 136
 None
 0.98A 5igiA-3of5A:
undetectable		 5igiA-3of5A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 3of5 DETHIOBIOTIN
SYNTHETASE
(Francisella
tularensis) 		3 / 3 LYS A  61
GLN A  29
ASN A  30
 None
 0.91A 5l2tA-3of5A:
undetectable		 5l2tA-3of5A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 3of5 DETHIOBIOTIN
SYNTHETASE
(Francisella
tularensis) 		5 / 6 ILE A 133
ALA A 135
LEU A 136
ILE A 100
TYR A 123
 None
 1.38A 5mvmB-3of5A:
undetectable
5mvmC-3of5A:
undetectable		 5mvmB-3of5A:
19.67
5mvmC-3of5A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 3of5 DETHIOBIOTIN
SYNTHETASE
(Francisella
tularensis) 		3 / 3 TRP A 171
ILE A 187
GLU A 192
 None
 0.86A 6hcxA-3of5A:
undetectable		 6hcxA-3of5A:
15.62