SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ofl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3ofl L1
(Alphapapillomavi
rus
7) 		3 / 3 GLN A 378
ILE A 399
HIS A 326
 None
 0.72A 1fm9A-3oflA:
undetectable		 1fm9A-3oflA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3ofl L1
(Alphapapillomavi
rus
7) 		3 / 3 GLN A 378
ILE A 399
HIS A 326
 None
 0.72A 1k74A-3oflA:
undetectable		 1k74A-3oflA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 3ofl L1
(Alphapapillomavi
rus
7) 		4 / 6 TRP A 448
ARG A  71
GLY A 198
ASP A 197
 None
 1.47A 1kf6M-3oflA:
undetectable
1kf6N-3oflA:
undetectable		 1kf6M-3oflA:
20.92
1kf6N-3oflA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3ofl L1
(Alphapapillomavi
rus
7) 		3 / 3 LEU A 213
HIS A 168
ILE A 228
 None
 0.57A 1s9pB-3oflA:
undetectable		 1s9pB-3oflA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 3ofl L1
(Alphapapillomavi
rus
7) 		3 / 3 ASP A 240
PHE A 247
ASN A 396
 None
 0.85A 1sg9B-3oflA:
undetectable		 1sg9B-3oflA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 3ofl L1
(Alphapapillomavi
rus
7) 		5 / 12 GLN A 328
ALA A 162
ASP A 402
ASP A 244
SER A 398
 None
 1.25A 2nv4B-3oflA:
undetectable		 2nv4B-3oflA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3ofl L1
(Alphapapillomavi
rus
7) 		3 / 3 VAL A 139
SER A 137
LEU A 126
 None
 0.73A 3n8xA-3oflA:
undetectable		 3n8xA-3oflA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 3ofl L1
(Alphapapillomavi
rus
7) 		5 / 12 LEU A 445
VAL A 194
PRO A 163
HIS A 326
SER A 398
 None
 1.32A 4hvcB-3oflA:
undetectable		 4hvcB-3oflA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 3ofl L1
(Alphapapillomavi
rus
7) 		3 / 3 CYH A 229
LYS A 230
HIS A 168
 None
 1.12A 5js5A-3oflA:
undetectable		 5js5A-3oflA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 3ofl L1
(Alphapapillomavi
rus
7) 		4 / 7 SER A 398
PRO A 441
TYR A 442
ASN A 396
 None
 1.02A 5l1fC-3oflA:
undetectable		 5l1fC-3oflA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 3ofl L1
(Alphapapillomavi
rus
7) 		4 / 8 TYR A  35
THR A  88
TRP A 100
LEU A  98
 None
 1.14A 6cnjD-3oflA:
undetectable
6cnjE-3oflA:
undetectable		 6cnjD-3oflA:
11.56
6cnjE-3oflA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 3ofl L1
(Alphapapillomavi
rus
7) 		3 / 3 TYR A 463
ASP A 461
GLN A 462
 None
 0.73A 6g1pA-3oflA:
undetectable		 6g1pA-3oflA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 3ofl L1
(Alphapapillomavi
rus
7) 		4 / 8 VAL A 149
TYR A 151
HIS A 120
TYR A  49
 None
 1.32A 6gneB-3oflA:
undetectable		 6gneB-3oflA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3ofl L1
(Alphapapillomavi
rus
7) 		4 / 6 GLY A 243
VAL A 194
PHE A 330
PHE A 447
 None
 0.92A 6h7lA-3oflA:
undetectable		 6h7lA-3oflA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3ofl L1
(Alphapapillomavi
rus
7) 		4 / 6 GLY A 243
VAL A 194
PHE A 330
PHE A 447
 None
 0.92A 6h7lB-3oflA:
undetectable		 6h7lB-3oflA:
10.91