SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ogf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JHD_E_EDTE301_0 (BETA-2-MICROGLOBULIN TCRBETA CHAIN)	3ogf	DE NOVO DESIGNED DIMERIC TREFOIL-FOLD SUB-DOMAIN WHICH FORMS HOMO-TRIMER ASSEMBLY (synthetic construct)	4 / 8	SER A 58 THR A 59 ARG A 24 ILE A 42	None	1.12A	5jhdE-3ogfA: undetectable 5jhdG-3ogfA: undetectable	5jhdE-3ogfA: 17.50 5jhdG-3ogfA: 20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M45_A_ACTA803_0 (ACETONE CARBOXYLASE ALPHA SUBUNIT)	3ogf	DE NOVO DESIGNED DIMERIC TREFOIL-FOLD SUB-DOMAIN WHICH FORMS HOMO-TRIMER ASSEMBLY (synthetic construct)	4 / 4	GLU A 49 PRO A 48 ILE A 46 LEU A 55	None	1.29A	5m45A-3ogfA: undetectable	5m45A-3ogfA: 8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M45_D_ACTD803_0 (ACETONE CARBOXYLASE ALPHA SUBUNIT)	3ogf	DE NOVO DESIGNED DIMERIC TREFOIL-FOLD SUB-DOMAIN WHICH FORMS HOMO-TRIMER ASSEMBLY (synthetic construct)	4 / 4	GLU A 49 PRO A 48 ILE A 46 LEU A 55	None	1.31A	5m45D-3ogfA: undetectable	5m45D-3ogfA: 8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M45_G_ACTG803_0 (ACETONE CARBOXYLASE ALPHA SUBUNIT)	3ogf	DE NOVO DESIGNED DIMERIC TREFOIL-FOLD SUB-DOMAIN WHICH FORMS HOMO-TRIMER ASSEMBLY (synthetic construct)	4 / 4	GLU A 49 PRO A 48 ILE A 46 LEU A 55	None	1.28A	5m45G-3ogfA: undetectable	5m45G-3ogfA: 8.52

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["5JHD_E_EDTE301_0","BETA-2-MICROGLOBULIN;TCRBETA CHAIN","3ogf","DE NOVO DESIGNED DIMERIC TREFOIL-FOLD SUB-DOMAIN WHICH FORMS HOMO-TRIMER ASSEMBLY","synthetic construct",4,"SER A  58;THR A  59;ARG A  24;ILE A  42","None","1.12A","5jhdE-3ogfA:undetectable;5jhdG-3ogfA:undetectable","5jhdE-3ogfA:17.50;5jhdG-3ogfA:20.59"],["5M45_A_ACTA803_0","ACETONE CARBOXYLASE ALPHA SUBUNIT","3ogf","DE NOVO DESIGNED DIMERIC TREFOIL-FOLD SUB-DOMAIN WHICH FORMS HOMO-TRIMER ASSEMBLY","synthetic construct",4,"GLU A  49;PRO A  48;ILE A  46;LEU A  55","None","1.29A","5m45A-3ogfA:undetectable","5m45A-3ogfA:8.52"],["5M45_D_ACTD803_0","ACETONE CARBOXYLASE ALPHA SUBUNIT","3ogf","DE NOVO DESIGNED DIMERIC TREFOIL-FOLD SUB-DOMAIN WHICH FORMS HOMO-TRIMER ASSEMBLY","synthetic construct",4,"GLU A  49;PRO A  48;ILE A  46;LEU A  55","None","1.31A","5m45D-3ogfA:undetectable","5m45D-3ogfA:8.52"],["5M45_G_ACTG803_0","ACETONE CARBOXYLASE ALPHA SUBUNIT","3ogf","DE NOVO DESIGNED DIMERIC TREFOIL-FOLD SUB-DOMAIN WHICH FORMS HOMO-TRIMER ASSEMBLY","synthetic construct",4,"GLU A  49;PRO A  48;ILE A  46;LEU A  55","None","1.28A","5m45G-3ogfA:undetectable","5m45G-3ogfA:8.52"]]