SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ogg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 3ogg BOTULINUM NEUROTOXIN
TYPE D
(Clostridium
botulinum) 		4 / 6 TRP A1274
TYR A1123
ILE A1101
GLY A1132
 None
 0.80A 1maaB-3oggA:
undetectable
1maaD-3oggA:
undetectable		 1maaB-3oggA:
18.72
1maaD-3oggA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3ogg BOTULINUM NEUROTOXIN
TYPE D
(Clostridium
botulinum) 		4 / 8 TYR A1014
ASN A1010
GLU A1030
GLY A1013
 None
 0.79A 1ykiA-3oggA:
undetectable
1ykiB-3oggA:
undetectable		 1ykiA-3oggA:
17.92
1ykiB-3oggA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3ogg BOTULINUM NEUROTOXIN
TYPE D
(Clostridium
botulinum) 		4 / 8 TYR A1014
ASN A1010
GLU A1030
GLY A1013
 None
 0.82A 1ykiA-3oggA:
undetectable
1ykiB-3oggA:
undetectable		 1ykiA-3oggA:
17.92
1ykiB-3oggA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3ogg BOTULINUM NEUROTOXIN
TYPE D
(Clostridium
botulinum) 		4 / 8 TYR A1014
ASN A1010
GLU A1030
GLY A1013
 None
 0.82A 1ykiC-3oggA:
undetectable
1ykiD-3oggA:
undetectable		 1ykiC-3oggA:
17.92
1ykiD-3oggA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3ogg BOTULINUM NEUROTOXIN
TYPE D
(Clostridium
botulinum) 		4 / 8 TYR A1076
ASN A1073
GLU A1022
GLY A1021
 None
 1.08A 1ykiC-3oggA:
undetectable
1ykiD-3oggA:
undetectable		 1ykiC-3oggA:
17.92
1ykiD-3oggA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3ogg BOTULINUM NEUROTOXIN
TYPE D
(Clostridium
botulinum) 		4 / 8 TYR A1014
ASN A1010
GLU A1030
GLY A1013
 None
 0.77A 1ykiC-3oggA:
undetectable
1ykiD-3oggA:
undetectable		 1ykiC-3oggA:
17.92
1ykiD-3oggA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 3ogg BOTULINUM NEUROTOXIN
TYPE D
(Clostridium
botulinum) 		4 / 5 LEU A 918
ASP A 881
ALA A 887
ILE A1062
 None
 1.06A 2qhfA-3oggA:
undetectable		 2qhfA-3oggA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3ogg BOTULINUM NEUROTOXIN
TYPE D
(Clostridium
botulinum) 		5 / 10 ALA A1250
LEU A1191
ILE A1220
ILE A1111
THR A1228
 None
 1.19A 2w9sC-3oggA:
undetectable		 2w9sC-3oggA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 3ogg BOTULINUM NEUROTOXIN
TYPE D
(Clostridium
botulinum) 		3 / 3 GLY A 884
ASP A 881
SER A 871
 None
 0.60A 3brfA-3oggA:
7.8		 3brfA-3oggA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3ogg BOTULINUM NEUROTOXIN
TYPE D
(Clostridium
botulinum) 		4 / 7 PHE A1060
ASP A1038
ILE A1007
VAL A1005
 None
 0.95A 3p6hA-3oggA:
undetectable		 3p6hA-3oggA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3ogg BOTULINUM NEUROTOXIN
TYPE D
(Clostridium
botulinum) 		3 / 3 THR A1252
ASN A1253
GLU A1226
 None
 0.75A 3v4tA-3oggA:
undetectable
3v4tC-3oggA:
undetectable		 3v4tA-3oggA:
23.14
3v4tC-3oggA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 3ogg BOTULINUM NEUROTOXIN
TYPE D
(Clostridium
botulinum) 		3 / 3 ARG A1082
ASP A1059
GLN A 873
 None
 0.76A 4azsA-3oggA:
undetectable		 4azsA-3oggA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 3ogg BOTULINUM NEUROTOXIN
TYPE D
(Clostridium
botulinum) 		4 / 8 ILE A1101
ILE A1207
PHE A1205
GLY A1203
 None
 0.94A 4hdlA-3oggA:
undetectable		 4hdlA-3oggA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 3ogg BOTULINUM NEUROTOXIN
TYPE D
(Clostridium
botulinum) 		4 / 4 ILE A 956
SER A 955
ASP A 977
ASP A1031
 None
 1.30A 4krhB-3oggA:
undetectable		 4krhB-3oggA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		 3ogg BOTULINUM NEUROTOXIN
TYPE D
(Clostridium
botulinum) 		3 / 3 THR A 999
SER A 990
TYR A 989
 None
 0.86A 5jsdA-3oggA:
undetectable		 5jsdA-3oggA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		 3ogg BOTULINUM NEUROTOXIN
TYPE D
(Clostridium
botulinum) 		3 / 3 THR A 999
SER A 990
TYR A 989
 None
 0.86A 5jsdC-3oggA:
undetectable		 5jsdC-3oggA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 3ogg BOTULINUM NEUROTOXIN
TYPE D
(Clostridium
botulinum) 		4 / 8 VAL A 916
LEU A 918
ASN A1061
VAL A 933
 None
 0.81A 5nujA-3oggA:
undetectable		 5nujA-3oggA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3ogg BOTULINUM NEUROTOXIN
TYPE D
(Clostridium
botulinum) 		5 / 10 TYR A1216
ILE A1101
ILE A1111
LEU A1118
ILE A1207
 None
 1.39A 5vkqA-3oggA:
undetectable
5vkqD-3oggA:
undetectable		 5vkqA-3oggA:
13.12
5vkqD-3oggA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3ogg BOTULINUM NEUROTOXIN
TYPE D
(Clostridium
botulinum) 		5 / 10 ILE A1207
TYR A1216
ILE A1101
ILE A1111
LEU A1118
 None
 1.40A 5vkqA-3oggA:
undetectable
5vkqB-3oggA:
undetectable		 5vkqA-3oggA:
13.12
5vkqB-3oggA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3ogg BOTULINUM NEUROTOXIN
TYPE D
(Clostridium
botulinum) 		5 / 10 ILE A1207
TYR A1216
ILE A1101
ILE A1111
LEU A1118
 None
 1.39A 5vkqC-3oggA:
undetectable
5vkqD-3oggA:
undetectable		 5vkqC-3oggA:
13.12
5vkqD-3oggA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3ogg BOTULINUM NEUROTOXIN
TYPE D
(Clostridium
botulinum) 		5 / 12 LEU A1191
PHE A1221
GLN A1219
LEU A1093
ILE A1101
 None
 1.08A 5y2tA-3oggA:
undetectable		 5y2tA-3oggA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3ogg BOTULINUM NEUROTOXIN
TYPE D
(Clostridium
botulinum) 		4 / 8 ILE A1268
TRP A1089
ARG A1270
ASN A1000
 None
 1.15A 6hisA-3oggA:
undetectable
6hisB-3oggA:
undetectable		 6hisA-3oggA:
11.28
6hisB-3oggA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3ogg BOTULINUM NEUROTOXIN
TYPE D
(Clostridium
botulinum) 		4 / 8 ILE A1268
TRP A1089
ARG A1270
ASN A1000
 None
 1.15A 6hisB-3oggA:
undetectable
6hisC-3oggA:
undetectable		 6hisB-3oggA:
11.28
6hisC-3oggA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3ogg BOTULINUM NEUROTOXIN
TYPE D
(Clostridium
botulinum) 		4 / 8 ILE A1268
TRP A1089
ARG A1270
ASN A1000
 None
 1.14A 6hisC-3oggA:
undetectable
6hisD-3oggA:
undetectable		 6hisC-3oggA:
11.28
6hisD-3oggA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3ogg BOTULINUM NEUROTOXIN
TYPE D
(Clostridium
botulinum) 		4 / 8 ILE A1268
TRP A1089
ARG A1270
ASN A1000
 None
 1.16A 6hisD-3oggA:
undetectable
6hisE-3oggA:
undetectable		 6hisD-3oggA:
11.28
6hisE-3oggA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3ogg BOTULINUM NEUROTOXIN
TYPE D
(Clostridium
botulinum) 		4 / 8 ASN A1000
ILE A1268
TRP A1089
ARG A1270
 None
 1.14A 6hisA-3oggA:
undetectable
6hisE-3oggA:
undetectable		 6hisA-3oggA:
11.28
6hisE-3oggA:
11.28