SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ogz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 10 LEU A 473
VAL A 523
ILE A 525
LEU A 500
VAL A 516
 None
 0.99A 1cqpA-3ogzA:
undetectable
1cqpB-3ogzA:
undetectable		 1cqpA-3ogzA:
14.26
1cqpB-3ogzA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 10 PHE A 268
VAL A 227
VAL A 118
VAL A 116
LEU A 254
 None
 1.12A 1fe2A-3ogzA:
undetectable		 1fe2A-3ogzA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 12 GLY A 456
VAL A 485
LEU A 437
ALA A 440
PHE A 490
 None
 0.91A 1gseB-3ogzA:
undetectable		 1gseB-3ogzA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		4 / 7 GLY A 122
THR A 177
HIS A 174
THR A 173
 None
 0.89A 1gtfL-3ogzA:
undetectable
1gtfM-3ogzA:
undetectable		 1gtfL-3ogzA:
6.79
1gtfM-3ogzA:
6.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		4 / 8 GLY A 122
THR A 177
HIS A 174
THR A 173
 None
 0.87A 1gtfN-3ogzA:
undetectable
1gtfO-3ogzA:
undetectable		 1gtfN-3ogzA:
6.79
1gtfO-3ogzA:
6.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_1
(HIV-1 PROTEASE)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 12 GLY A 122
ALA A 121
ASP A 271
ILE A 269
ILE A 167
 None
 0.77A 1hxbA-3ogzA:
undetectable		 1hxbA-3ogzA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 10 THR A 173
ILE A 133
LEU A 181
LEU A 186
THR A 146
 None
 1.34A 1i18A-3ogzA:
undetectable
1i18B-3ogzA:
undetectable		 1i18A-3ogzA:
10.18
1i18B-3ogzA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 11 SER A 358
ALA A 276
VAL A 120
LEU A 119
THR A 297
 None
 1.00A 1jinA-3ogzA:
undetectable		 1jinA-3ogzA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 12 PHE A 268
ILE A 409
THR A 235
LEU A 373
LEU A 194
 None
 1.32A 1kqwA-3ogzA:
undetectable		 1kqwA-3ogzA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		3 / 3 ASP A 271
LYS A 434
ARG A 127
 None
 1.01A 1ra8A-3ogzA:
undetectable		 1ra8A-3ogzA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 10 LEU A  21
GLU A  15
LEU A  16
ILE A  63
LEU A  48
 None
 1.16A 1wopA-3ogzA:
undetectable		 1wopA-3ogzA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_2
(HIV-1 PROTEASE)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 11 GLY A 122
ALA A 121
ASP A 271
ILE A 269
ILE A 167
 None
 0.87A 2aquB-3ogzA:
undetectable		 2aquB-3ogzA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_2
(POL PROTEIN)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 11 GLY A 122
ALA A 121
ASP A 271
ILE A 269
ILE A 167
 None
 0.89A 2fxeB-3ogzA:
undetectable		 2fxeB-3ogzA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_1
(PROTEASE)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 12 GLY A 122
ALA A 121
ASP A 271
ILE A 269
ILE A 167
 None
 0.87A 2nmyA-3ogzA:
undetectable		 2nmyA-3ogzA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_2
(PROTEASE)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		6 / 12 GLY A 122
ALA A 121
ASP A 271
ILE A 269
VAL A 227
ILE A 167
 None
 1.29A 2o4lB-3ogzA:
undetectable		 2o4lB-3ogzA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_1
(PROTEASE RETROPEPSIN)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 12 GLY A 122
ALA A 121
ASP A 271
ILE A 269
ILE A 167
 None
 0.86A 2q64A-3ogzA:
undetectable		 2q64A-3ogzA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 12 GLY A 122
ALA A 121
ASP A 271
ILE A 269
ILE A 167
 None
 0.86A 2qakA-3ogzA:
undetectable		 2qakA-3ogzA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		3 / 3 HIS A 224
MET A 406
MET A 168
 None
 1.43A 2vj1A-3ogzA:
undetectable		 2vj1A-3ogzA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 9 PRO A 381
VAL A 380
GLY A 378
ILE A 231
GLY A 225
 None
 1.18A 3csjB-3ogzA:
undetectable		 3csjB-3ogzA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_1
(HIV-1 PROTEASE)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 12 GLY A 122
ALA A 121
ASP A 271
ILE A 269
ILE A 167
 None
 0.81A 3cyxA-3ogzA:
undetectable		 3cyxA-3ogzA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_1
(HIV-1 PROTEASE)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 12 GLY A 122
ALA A 121
ASP A 271
ILE A 269
ILE A 167
 None
 0.87A 3d1xA-3ogzA:
undetectable		 3d1xA-3ogzA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 12 PHE A 296
LEU A 310
GLY A 357
PHE A 355
SER A 429
 None
 1.19A 3dh0A-3ogzA:
2.2		 3dh0A-3ogzA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_1
(PROTEASE)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 12 GLY A 122
ALA A 121
ASP A 271
ILE A 269
ILE A 167
 None
 0.87A 3ekqA-3ogzA:
undetectable		 3ekqA-3ogzA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_2
(PROTEASE)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 12 GLY A 122
ALA A 121
ASP A 271
ILE A 269
ILE A 167
 None
 0.90A 3ekwB-3ogzA:
undetectable		 3ekwB-3ogzA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_2
(PROTEASE)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 12 GLY A 122
ALA A 121
ASP A 271
ILE A 269
ILE A 167
 None
 0.87A 3el1B-3ogzA:
undetectable		 3el1B-3ogzA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_1
(PROTEASE)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 11 GLY A 122
ALA A 121
ASP A 271
ILE A 269
ILE A 167
 None
 0.87A 3em4U-3ogzA:
undetectable		 3em4U-3ogzA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 9 GLN A 270
VAL A 120
HIS A 224
VAL A 380
GLN A 407
 None
 1.32A 3fi0D-3ogzA:
undetectable		 3fi0D-3ogzA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 9 GLN A 270
VAL A 120
HIS A 224
VAL A 380
GLN A 407
 None
 1.30A 3fi0F-3ogzA:
undetectable		 3fi0F-3ogzA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 9 GLN A 270
VAL A 120
HIS A 224
VAL A 380
GLN A 407
 None
 1.33A 3fi0J-3ogzA:
undetectable		 3fi0J-3ogzA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_R_TRPR1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 9 GLN A 270
VAL A 120
HIS A 224
VAL A 380
GLN A 407
 None
 1.29A 3fi0R-3ogzA:
undetectable		 3fi0R-3ogzA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		3 / 3 MET A 294
MET A 111
PHE A 268
 None
 1.17A 3gn8A-3ogzA:
undetectable		 3gn8A-3ogzA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IXL_A_PACA5000_0
(ARYLMALONATE
DECARBOXYLASE)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 10 PRO A 356
CYH A 298
SER A 358
GLY A 422
GLY A 421
 None
 1.45A 3ixlA-3ogzA:
undetectable		 3ixlA-3ogzA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IXL_A_PACA5000_0
(ARYLMALONATE
DECARBOXYLASE)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 10 PRO A 356
CYH A 298
THR A 297
GLY A 422
GLY A 421
 None
 1.30A 3ixlA-3ogzA:
undetectable		 3ixlA-3ogzA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_1
(HIV-1 PROTEASE)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 12 GLY A 122
ALA A 121
ASP A 271
ILE A 269
ILE A 167
 None
 0.77A 3k4vA-3ogzA:
undetectable		 3k4vA-3ogzA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_3
(HIV-1 PROTEASE)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 12 GLY A 122
ALA A 121
ASP A 271
ILE A 269
ILE A 167
 None
 0.91A 3k4vD-3ogzA:
undetectable		 3k4vD-3ogzA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 11 THR A 115
ALA A 285
GLY A 108
THR A 109
ALA A 110
 None
 1.12A 3mg0H-3ogzA:
undetectable
3mg0I-3ogzA:
undetectable		 3mg0H-3ogzA:
16.56
3mg0I-3ogzA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		4 / 8 VAL A 380
GLY A 378
ILE A 231
GLY A 225
 None
 0.69A 3n9jB-3ogzA:
undetectable		 3n9jB-3ogzA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_2
(PROTEASE)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 12 GLY A 122
ALA A 121
ASP A 271
ILE A 269
ILE A 167
 None
 0.91A 3nduD-3ogzA:
undetectable		 3nduD-3ogzA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_2
(PROTEASE)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 11 GLY A 122
ALA A 121
ASP A 271
ILE A 269
ILE A 167
 None
 0.88A 3ndxB-3ogzA:
undetectable		 3ndxB-3ogzA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_1
(PROTEASE)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 12 GLY A 122
ALA A 121
ASP A 271
ILE A 269
ILE A 167
 None
 0.86A 3oxcA-3ogzA:
undetectable		 3oxcA-3ogzA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_B_GLYB511_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		4 / 5 SER A 136
GLU A 183
LEU A 180
GLN A 179
 None
 1.41A 3pgyB-3ogzA:
undetectable		 3pgyB-3ogzA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_1
(PROTEASE)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 12 GLY A 122
ALA A 121
ASP A 271
ILE A 269
ILE A 167
 None
 0.89A 3pwrA-3ogzA:
undetectable		 3pwrA-3ogzA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_1
(PROTEASE)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 12 GLY A 122
ALA A 121
ASP A 271
ILE A 269
ILE A 167
 None
 0.85A 3tkgA-3ogzA:
undetectable		 3tkgA-3ogzA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_1
(PROTEASE)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 12 GLY A 122
ALA A 121
ASP A 271
ILE A 269
ILE A 167
 None
 0.87A 3tkgC-3ogzA:
undetectable		 3tkgC-3ogzA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 9 THR A 115
LEU A 284
GLY A 108
THR A 109
VAL A 158
 None
 1.48A 4c9kA-3ogzA:
undetectable		 4c9kA-3ogzA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 9 TRP A 154
THR A 115
THR A 277
LEU A 284
THR A 361
 None
 1.45A 4c9kA-3ogzA:
undetectable		 4c9kA-3ogzA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 12 GLY A 123
HIS A 174
THR A 177
ILE A 167
VAL A 193
 None
 1.19A 4okwA-3ogzA:
undetectable		 4okwA-3ogzA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		3 / 3 ASP A  47
LEU A  48
PHE A  51
 None
 0.69A 4pthA-3ogzA:
undetectable		 4pthA-3ogzA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 11 THR A 115
ALA A 285
GLY A 108
THR A 109
ALA A 110
 None
 1.15A 4qvvH-3ogzA:
undetectable		 4qvvH-3ogzA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 11 THR A 115
ALA A 285
GLY A 108
THR A 109
ALA A 110
 None
 1.15A 4qvvV-3ogzA:
undetectable		 4qvvV-3ogzA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 12 ILE A 539
ASN A 565
VAL A 523
HIS A 524
ILE A 525
 None
 1.04A 4rvgA-3ogzA:
undetectable		 4rvgA-3ogzA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		4 / 7 ALA A 566
ASP A 609
ARG A 551
GLU A 534
 None
 0.85A 5bs8A-3ogzA:
undetectable
5bs8C-3ogzA:
undetectable
5bs8D-3ogzA:
undetectable		 5bs8A-3ogzA:
23.79
5bs8C-3ogzA:
23.79
5bs8D-3ogzA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 11 THR A 115
ALA A 285
GLY A 108
THR A 109
ALA A 110
 None
 1.14A 5d0xV-3ogzA:
undetectable		 5d0xV-3ogzA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		4 / 8 GLY A 122
THR A 177
HIS A 174
THR A 173
 None
 0.87A 5eevL-3ogzA:
undetectable
5eevV-3ogzA:
undetectable		 5eevL-3ogzA:
6.79
5eevV-3ogzA:
6.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		4 / 8 GLY A 122
THR A 177
HIS A 174
THR A 173
 None
 0.87A 5eewL-3ogzA:
undetectable
5eewV-3ogzA:
undetectable		 5eewL-3ogzA:
6.79
5eewV-3ogzA:
6.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		4 / 8 GLY A 122
THR A 177
HIS A 174
THR A 173
 None
 0.87A 5eezL-3ogzA:
undetectable
5eezV-3ogzA:
undetectable		 5eezL-3ogzA:
6.79
5eezV-3ogzA:
6.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		4 / 8 GLY A 122
THR A 177
HIS A 174
THR A 173
 None
 0.87A 5ef1L-3ogzA:
undetectable
5ef1V-3ogzA:
undetectable		 5ef1L-3ogzA:
6.79
5ef1V-3ogzA:
6.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		4 / 8 GLY A 122
THR A 177
HIS A 174
THR A 173
 None
 0.87A 5ef2L-3ogzA:
undetectable
5ef2V-3ogzA:
undetectable		 5ef2L-3ogzA:
6.79
5ef2V-3ogzA:
6.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		4 / 8 GLY A 122
THR A 177
HIS A 174
THR A 173
 None
 0.87A 5ef3L-3ogzA:
undetectable
5ef3V-3ogzA:
undetectable		 5ef3L-3ogzA:
6.79
5ef3V-3ogzA:
6.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 12 GLY A  57
TYR A  62
ASP A 226
HIS A 222
ARG A 219
 None
 1.27A 5igwA-3ogzA:
undetectable		 5igwA-3ogzA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		4 / 6 ILE A 498
GLY A 572
ASN A 570
ILE A 497
 None
 0.87A 5j4nB-3ogzA:
undetectable		 5j4nB-3ogzA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_1
(PROTEASE E35D-SQV)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 12 GLY A 122
ALA A 121
ASP A 271
ILE A 269
ILE A 167
 None
 0.85A 5kqxA-3ogzA:
undetectable		 5kqxA-3ogzA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		4 / 6 ARG A  13
LEU A  12
ALA A  60
GLN A  10
 None
 1.06A 6b89B-3ogzA:
undetectable		 6b89B-3ogzA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_0
(PROTEASE)		 3ogz UDP-SUGAR
PYROPHOSPHORYLASE
(Leishmania
major) 		5 / 12 GLY A 122
ALA A 121
ASP A 271
ILE A 269
ILE A 167
 None
 0.98A 6dh6A-3ogzA:
undetectable		 6dh6A-3ogzA:
8.71