SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3oht'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_B_ACAB90_1
(PLASMINOGEN)		 3oht P38A
(Salmo
salar) 		4 / 7 ASP A 151
ASP A 169
TYR A 324
ARG A  74
 None
1N1  A1000 (-3.4A)
None
None
 1.31A 1ceaB-3ohtA:
undetectable		 1ceaB-3ohtA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_B_AMHB90_1
(PLASMINOGEN)		 3oht P38A
(Salmo
salar) 		4 / 7 ASP A 151
ASP A 169
TYR A 324
ARG A  74
 None
1N1  A1000 (-3.4A)
None
None
 1.32A 1cebB-3ohtA:
undetectable		 1cebB-3ohtA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3oht P38A
(Salmo
salar) 		7 / 12 ALA A  52
LYS A  54
GLU A  72
LEU A 105
THR A 107
LEU A 109
MET A 110
 1N1  A1000 (-3.7A)
1N1  A1000 (-4.5A)
1N1  A1000 (-4.2A)
1N1  A1000 (-4.2A)
1N1  A1000 (-3.3A)
1N1  A1000 (-4.7A)
None
 0.57A 1m17A-3ohtA:
3.8		 1m17A-3ohtA:
27.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3oht P38A
(Salmo
salar) 		5 / 9 LYS A  54
LEU A  87
LEU A 105
LEU A 109
MET A 110
 1N1  A1000 (-4.5A)
None
1N1  A1000 (-4.2A)
1N1  A1000 (-4.7A)
None
 0.77A 1xkkA-3ohtA:
6.8		 1xkkA-3ohtA:
27.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3oht P38A
(Salmo
salar) 		5 / 9 VAL A  39
LEU A  87
LEU A 105
LEU A 109
MET A 110
 1N1  A1000 (-4.6A)
None
1N1  A1000 (-4.2A)
1N1  A1000 (-4.7A)
None
 0.77A 1xkkA-3ohtA:
6.8		 1xkkA-3ohtA:
27.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)		 3oht P38A
(Salmo
salar) 		4 / 6 LEU A 217
LEU A 136
LEU A 157
ILE A 207
 None
 0.97A 1z95A-3ohtA:
undetectable		 1z95A-3ohtA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3oht P38A
(Salmo
salar) 		3 / 3 LEU A 105
LEU A 109
MET A 110
 1N1  A1000 (-4.2A)
1N1  A1000 (-4.7A)
None
 0.43A 2itzA-3ohtA:
16.6		 2itzA-3ohtA:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3oht P38A
(Salmo
salar) 		3 / 3 ASP A 325
TYR A 324
LYS A  77
 None
 1.04A 2othA-3ohtA:
undetectable		 2othA-3ohtA:
14.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3oht P38A
(Salmo
salar) 		5 / 12 ALA A  52
GLU A  72
LEU A  76
THR A 107
LEU A 168
 1N1  A1000 (-3.7A)
1N1  A1000 (-4.2A)
1N1  A1000 (-4.7A)
1N1  A1000 (-3.3A)
1N1  A1000 ( 3.7A)
 0.96A 3gcsA-3ohtA:
16.4		 3gcsA-3ohtA:
83.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3oht P38A
(Salmo
salar) 		7 / 12 ALA A  52
LEU A  75
LEU A  76
ILE A  85
THR A 107
ILE A 142
LEU A 168
 1N1  A1000 (-3.7A)
None
1N1  A1000 (-4.7A)
1N1  A1000 ( 4.1A)
1N1  A1000 (-3.3A)
None
1N1  A1000 ( 3.7A)
 0.74A 3gcsA-3ohtA:
16.4		 3gcsA-3ohtA:
83.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3oht P38A
(Salmo
salar) 		7 / 12 VAL A  39
ALA A  52
LEU A  75
LEU A  76
ILE A  85
THR A 107
ILE A 142
 1N1  A1000 (-4.6A)
1N1  A1000 (-3.7A)
None
1N1  A1000 (-4.7A)
1N1  A1000 ( 4.1A)
1N1  A1000 (-3.3A)
None
 0.72A 3gcsA-3ohtA:
16.4		 3gcsA-3ohtA:
83.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3oht P38A
(Salmo
salar) 		5 / 6 MET A  79
VAL A  84
LEU A 109
MET A 110
ILE A 147
 None
None
1N1  A1000 (-4.7A)
None
None
 1.07A 3gcsA-3ohtA:
16.5		 3gcsA-3ohtA:
83.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3oht P38A
(Salmo
salar) 		5 / 6 MET A  79
VAL A  84
MET A 110
ILE A 147
ILE A 167
 None
 0.84A 3gcsA-3ohtA:
16.5		 3gcsA-3ohtA:
83.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 3oht P38A
(Salmo
salar) 		8 / 12 VAL A  39
ALA A  52
GLU A  72
ILE A  85
THR A 107
ALA A 158
LEU A 168
PHE A 170
 1N1  A1000 (-4.6A)
1N1  A1000 (-3.7A)
1N1  A1000 (-4.2A)
1N1  A1000 ( 4.1A)
1N1  A1000 (-3.3A)
None
1N1  A1000 ( 3.7A)
1N1  A1000 (-4.5A)
 1.01A 3gp0A-3ohtA:
18.9		 3gp0A-3ohtA:
68.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 3oht P38A
(Salmo
salar) 		7 / 12 VAL A  39
ALA A  52
GLU A  72
LEU A  75
LEU A  76
THR A 107
LEU A 168
 1N1  A1000 (-4.6A)
1N1  A1000 (-3.7A)
1N1  A1000 (-4.2A)
None
1N1  A1000 (-4.7A)
1N1  A1000 (-3.3A)
1N1  A1000 ( 3.7A)
 0.64A 3gp0A-3ohtA:
18.9		 3gp0A-3ohtA:
68.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 3oht P38A
(Salmo
salar) 		8 / 12 VAL A  39
ALA A  52
GLU A  72
LEU A  76
ILE A  85
THR A 107
ALA A 158
LEU A 168
 1N1  A1000 (-4.6A)
1N1  A1000 (-3.7A)
1N1  A1000 (-4.2A)
1N1  A1000 (-4.7A)
1N1  A1000 ( 4.1A)
1N1  A1000 (-3.3A)
None
1N1  A1000 ( 3.7A)
 0.69A 3gp0A-3ohtA:
18.9		 3gp0A-3ohtA:
68.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 3oht P38A
(Salmo
salar) 		6 / 7 LYS A  54
VAL A  84
LEU A 105
LEU A 109
MET A 110
ILE A 167
 1N1  A1000 (-4.5A)
None
1N1  A1000 (-4.2A)
1N1  A1000 (-4.7A)
None
None
 0.82A 3gp0A-3ohtA:
18.9		 3gp0A-3ohtA:
68.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3oht P38A
(Salmo
salar) 		5 / 12 ALA A  52
ILE A  85
THR A 107
LEU A 109
PHE A 170
 1N1  A1000 (-3.7A)
1N1  A1000 ( 4.1A)
1N1  A1000 (-3.3A)
1N1  A1000 (-4.7A)
1N1  A1000 (-4.5A)
 0.71A 3hecA-3ohtA:
35.2		 3hecA-3ohtA:
87.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3oht P38A
(Salmo
salar) 		5 / 12 ALA A  52
ILE A  85
THR A 107
LEU A 168
PHE A 170
 1N1  A1000 (-3.7A)
1N1  A1000 ( 4.1A)
1N1  A1000 (-3.3A)
1N1  A1000 ( 3.7A)
1N1  A1000 (-4.5A)
 0.85A 3hecA-3ohtA:
35.2		 3hecA-3ohtA:
87.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3oht P38A
(Salmo
salar) 		9 / 12 VAL A  31
ALA A  52
LYS A  54
GLU A  72
LEU A  75
LEU A  76
ILE A  85
THR A 107
LEU A 168
 1N1  A1000 ( 4.3A)
1N1  A1000 (-3.7A)
1N1  A1000 (-4.5A)
1N1  A1000 (-4.2A)
None
1N1  A1000 (-4.7A)
1N1  A1000 ( 4.1A)
1N1  A1000 (-3.3A)
1N1  A1000 ( 3.7A)
 0.63A 3hecA-3ohtA:
35.2		 3hecA-3ohtA:
87.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3oht P38A
(Salmo
salar) 		8 / 12 VAL A  31
ALA A  52
LYS A  54
GLU A  72
LEU A  76
ILE A  85
THR A 107
LEU A 109
 1N1  A1000 ( 4.3A)
1N1  A1000 (-3.7A)
1N1  A1000 (-4.5A)
1N1  A1000 (-4.2A)
1N1  A1000 (-4.7A)
1N1  A1000 ( 4.1A)
1N1  A1000 (-3.3A)
1N1  A1000 (-4.7A)
 0.64A 3hecA-3ohtA:
35.2		 3hecA-3ohtA:
87.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3oht P38A
(Salmo
salar) 		6 / 12 VAL A  31
VAL A  39
ALA A  52
LEU A 152
ILE A  85
THR A 107
 1N1  A1000 ( 4.3A)
1N1  A1000 (-4.6A)
1N1  A1000 (-3.7A)
None
1N1  A1000 ( 4.1A)
1N1  A1000 (-3.3A)
 1.48A 3hegA-3ohtA:
18.6		 3hegA-3ohtA:
87.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3oht P38A
(Salmo
salar) 		8 / 12 VAL A  31
VAL A  39
ALA A  52
LYS A  54
GLU A  72
LEU A  75
LEU A  76
THR A 107
 1N1  A1000 ( 4.3A)
1N1  A1000 (-4.6A)
1N1  A1000 (-3.7A)
1N1  A1000 (-4.5A)
1N1  A1000 (-4.2A)
None
1N1  A1000 (-4.7A)
1N1  A1000 (-3.3A)
 0.77A 3hegA-3ohtA:
18.6		 3hegA-3ohtA:
87.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3oht P38A
(Salmo
salar) 		9 / 12 VAL A  31
VAL A  39
ALA A  52
LYS A  54
LEU A  75
LEU A  76
ILE A  85
THR A 107
ILE A 142
 1N1  A1000 ( 4.3A)
1N1  A1000 (-4.6A)
1N1  A1000 (-3.7A)
1N1  A1000 (-4.5A)
None
1N1  A1000 (-4.7A)
1N1  A1000 ( 4.1A)
1N1  A1000 (-3.3A)
None
 0.68A 3hegA-3ohtA:
18.6		 3hegA-3ohtA:
87.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3oht P38A
(Salmo
salar) 		7 / 12 VAL A  31
VAL A  39
ALA A  52
LYS A  54
LEU A  76
THR A 107
ILE A 147
 1N1  A1000 ( 4.3A)
1N1  A1000 (-4.6A)
1N1  A1000 (-3.7A)
1N1  A1000 (-4.5A)
1N1  A1000 (-4.7A)
1N1  A1000 (-3.3A)
None
 1.33A 3hegA-3ohtA:
18.6		 3hegA-3ohtA:
87.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3oht P38A
(Salmo
salar) 		6 / 12 VAL A  39
LYS A  54
GLU A  72
LEU A  76
THR A 107
ASP A 151
 1N1  A1000 (-4.6A)
1N1  A1000 (-4.5A)
1N1  A1000 (-4.2A)
1N1  A1000 (-4.7A)
1N1  A1000 (-3.3A)
None
 1.44A 3hegA-3ohtA:
18.6		 3hegA-3ohtA:
87.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3oht P38A
(Salmo
salar) 		5 / 6 MET A  79
VAL A  84
ILE A 147
ILE A 167
LEU A 168
 None
None
None
None
1N1  A1000 ( 3.7A)
 0.67A 3hegA-3ohtA:
18.6		 3hegA-3ohtA:
87.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3oht P38A
(Salmo
salar) 		8 / 8 VAL A  31
ALA A  52
LYS A  54
GLU A  72
LEU A 105
THR A 107
LEU A 109
MET A 110
 1N1  A1000 ( 4.3A)
1N1  A1000 (-3.7A)
1N1  A1000 (-4.5A)
1N1  A1000 (-4.2A)
1N1  A1000 (-4.2A)
1N1  A1000 (-3.3A)
1N1  A1000 (-4.7A)
None
 0.47A 3lfaA-3ohtA:
15.7		 3lfaA-3ohtA:
84.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 3oht P38A
(Salmo
salar) 		3 / 3 LYS A 153
PRO A 154
LEU A 157
 None
 0.73A 3tpxE-3ohtA:
undetectable		 3tpxE-3ohtA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 3oht P38A
(Salmo
salar) 		5 / 12 ILE A 135
ALA A 300
ILE A 298
LEU A 286
ILE A 132
 None
 1.04A 4m2xG-3ohtA:
undetectable		 4m2xG-3ohtA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)		 3oht P38A
(Salmo
salar) 		5 / 12 LEU A  87
LEU A  76
GLY A  86
VAL A  53
THR A 351
 None
1N1  A1000 (-4.7A)
None
None
None
 1.41A 4oktA-3ohtA:
undetectable		 4oktA-3ohtA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 3oht P38A
(Salmo
salar) 		4 / 7 LEU A 217
LEU A 136
LEU A 157
ILE A 207
 None
 0.93A 4okwA-3ohtA:
undetectable		 4okwA-3ohtA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 3oht P38A
(Salmo
salar) 		5 / 10 ALA A  52
LYS A  54
ILE A  85
THR A 107
LEU A 109
 1N1  A1000 (-3.7A)
1N1  A1000 (-4.5A)
1N1  A1000 ( 4.1A)
1N1  A1000 (-3.3A)
1N1  A1000 (-4.7A)
 0.43A 4rz7A-3ohtA:
17.0		 4rz7A-3ohtA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3oht P38A
(Salmo
salar) 		4 / 7 VAL A  39
LYS A  54
ILE A  85
ILE A 167
 1N1  A1000 (-4.6A)
1N1  A1000 (-4.5A)
1N1  A1000 ( 4.1A)
None
 0.66A 4uxqA-3ohtA:
17.2		 4uxqA-3ohtA:
26.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 3oht P38A
(Salmo
salar) 		5 / 9 GLY A  32
VAL A  39
ALA A  52
ILE A  85
MET A 110
 1N1  A1000 (-3.4A)
1N1  A1000 (-4.6A)
1N1  A1000 (-3.7A)
1N1  A1000 ( 4.1A)
None
 0.67A 5lw1B-3ohtA:
29.9		 5lw1B-3ohtA:
35.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 3oht P38A
(Salmo
salar) 		6 / 10 GLY A  32
VAL A  39
ALA A  52
ILE A  85
LEU A 109
LEU A 168
 1N1  A1000 (-3.4A)
1N1  A1000 (-4.6A)
1N1  A1000 (-3.7A)
1N1  A1000 ( 4.1A)
1N1  A1000 (-4.7A)
1N1  A1000 ( 3.7A)
 1.01A 5lw1E-3ohtA:
17.1		 5lw1E-3ohtA:
35.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 3oht P38A
(Salmo
salar) 		6 / 10 GLY A  32
VAL A  39
ALA A  52
ILE A  85
LEU A 109
MET A 110
 1N1  A1000 (-3.4A)
1N1  A1000 (-4.6A)
1N1  A1000 (-3.7A)
1N1  A1000 ( 4.1A)
1N1  A1000 (-4.7A)
None
 0.76A 5lw1E-3ohtA:
17.1		 5lw1E-3ohtA:
35.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 3oht P38A
(Salmo
salar) 		5 / 9 GLY A  32
VAL A  39
ALA A  52
LEU A 109
LEU A 168
 1N1  A1000 (-3.4A)
1N1  A1000 (-4.6A)
1N1  A1000 (-3.7A)
1N1  A1000 (-4.7A)
1N1  A1000 ( 3.7A)
 0.79A 5lw1H-3ohtA:
30.0		 5lw1H-3ohtA:
35.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 3oht P38A
(Salmo
salar) 		5 / 9 GLY A  32
VAL A  39
ALA A  52
LEU A 109
MET A 110
 1N1  A1000 (-3.4A)
1N1  A1000 (-4.6A)
1N1  A1000 (-3.7A)
1N1  A1000 (-4.7A)
None
 0.58A 5lw1H-3ohtA:
30.0		 5lw1H-3ohtA:
35.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 3oht P38A
(Salmo
salar) 		4 / 8 THR A  92
ASN A 101
PHE A  60
PRO A  59
 None
 0.96A 5v4vA-3ohtA:
undetectable		 5v4vA-3ohtA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 3oht P38A
(Salmo
salar) 		4 / 8 THR A  92
ASN A 101
PHE A  60
PRO A  59
 None
 0.95A 5v4vB-3ohtA:
undetectable		 5v4vB-3ohtA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3oht P38A
(Salmo
salar) 		6 / 12 ALA A  52
LYS A  54
GLU A  72
LEU A 105
THR A 107
GLY A 111
 1N1  A1000 (-3.7A)
1N1  A1000 (-4.5A)
1N1  A1000 (-4.2A)
1N1  A1000 (-4.2A)
1N1  A1000 (-3.3A)
1N1  A1000 (-4.7A)
 0.50A 5vcvA-3ohtA:
18.2		 5vcvA-3ohtA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3oht P38A
(Salmo
salar) 		7 / 12 VAL A  39
ALA A  52
LYS A  54
GLU A  72
LEU A 105
THR A 107
GLY A 111
 1N1  A1000 (-4.6A)
1N1  A1000 (-3.7A)
1N1  A1000 (-4.5A)
1N1  A1000 (-4.2A)
1N1  A1000 (-4.2A)
1N1  A1000 (-3.3A)
1N1  A1000 (-4.7A)
 0.66A 5vcyA-3ohtA:
17.9		 5vcyA-3ohtA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3oht P38A
(Salmo
salar) 		8 / 12 VAL A  39
ALA A  52
LYS A  54
GLU A  72
ILE A  85
THR A 107
GLY A 111
ASP A 169
 1N1  A1000 (-4.6A)
1N1  A1000 (-3.7A)
1N1  A1000 (-4.5A)
1N1  A1000 (-4.2A)
1N1  A1000 ( 4.1A)
1N1  A1000 (-3.3A)
1N1  A1000 (-4.7A)
1N1  A1000 (-3.4A)
 0.73A 6bsdA-3ohtA:
8.3		 6bsdA-3ohtA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3oht P38A
(Salmo
salar) 		8 / 12 VAL A  39
ALA A  52
LYS A  54
GLU A  72
ILE A  85
THR A 107
MET A 110
ASP A 169
 1N1  A1000 (-4.6A)
1N1  A1000 (-3.7A)
1N1  A1000 (-4.5A)
1N1  A1000 (-4.2A)
1N1  A1000 ( 4.1A)
1N1  A1000 (-3.3A)
None
1N1  A1000 (-3.4A)
 0.60A 6bsdA-3ohtA:
8.3		 6bsdA-3ohtA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 3oht P38A
(Salmo
salar) 		5 / 12 ILE A 213
LEU A 218
PHE A 309
ILE A 167
LEU A 165
 None
 1.14A 6dwnC-3ohtA:
undetectable		 6dwnC-3ohtA:
12.89