SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3olo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M56_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3olo TWO-COMPONENT SENSOR
HISTIDINE KINASE
(Nostoc
sp.
PCC
7120) 		4 / 5 PHE A  78
LEU A  26
VAL A 109
VAL A  92
 None
 1.23A 2m56A-3oloA:
undetectable		 2m56A-3oloA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 3olo TWO-COMPONENT SENSOR
HISTIDINE KINASE
(Nostoc
sp.
PCC
7120) 		4 / 8 ASP A  59
LEU A  55
HIS A  65
LEU A  96
 None
 0.97A 2q0iA-3oloA:
undetectable		 2q0iA-3oloA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3olo TWO-COMPONENT SENSOR
HISTIDINE KINASE
(Nostoc
sp.
PCC
7120) 		5 / 12 TRP A  30
PHE A  98
SER A 107
ASP A  57
ILE A  58
 None
 1.13A 3iv6B-3oloA:
undetectable		 3iv6B-3oloA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3olo TWO-COMPONENT SENSOR
HISTIDINE KINASE
(Nostoc
sp.
PCC
7120) 		3 / 3 ASP A  59
ARG A  71
THR A  80
 None
 0.77A 4i13A-3oloA:
undetectable		 4i13A-3oloA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3olo TWO-COMPONENT SENSOR
HISTIDINE KINASE
(Nostoc
sp.
PCC
7120) 		3 / 3 ASP A  59
ARG A  71
THR A  80
 None
 0.74A 4p3rA-3oloA:
undetectable		 4p3rA-3oloA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3olo TWO-COMPONENT SENSOR
HISTIDINE KINASE
(Nostoc
sp.
PCC
7120) 		5 / 12 LEU A  26
SER A  95
VAL A 109
ALA A  22
TYR A  82
 None
 1.21A 5tzoB-3oloA:
undetectable		 5tzoB-3oloA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3olo TWO-COMPONENT SENSOR
HISTIDINE KINASE
(Nostoc
sp.
PCC
7120) 		4 / 6 GLN A  72
PHE A  98
LEU A  96
PHE A  78
 None
 1.11A 5zcoP-3oloA:
undetectable
5zcoW-3oloA:
undetectable		 5zcoP-3oloA:
15.71
5zcoW-3oloA:
17.95