SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3olq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 3olq UNIVERSAL STRESS
PROTEIN E
(Proteus
mirabilis) 		3 / 3 ARG A  22
ARG A  23
PRO A  19
 UNL  A 321 ( 3.4A)
UNL  A 321 ( 4.6A)
None
 1.08A 2wljA-3olqA:
undetectable		 2wljA-3olqA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_2
(PROTEASE)		 3olq UNIVERSAL STRESS
PROTEIN E
(Proteus
mirabilis) 		5 / 10 LEU A 289
ASP A 131
ILE A 300
ALA A 286
ILE A 290
 None
None
None
GOL  A 318 ( 4.6A)
None
 0.89A 3ekpB-3olqA:
undetectable		 3ekpB-3olqA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3olq UNIVERSAL STRESS
PROTEIN E
(Proteus
mirabilis) 		5 / 12 LEU A 172
GLY A 276
ALA A 279
SER A 278
LEU A 282
 None
 1.09A 3n8xB-3olqA:
undetectable		 3n8xB-3olqA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 3olq UNIVERSAL STRESS
PROTEIN E
(Proteus
mirabilis) 		5 / 12 LEU A 233
HIS A 169
LEU A 176
GLY A 270
LEU A 195
 None
 1.33A 3okxA-3olqA:
undetectable		 3okxA-3olqA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 3olq UNIVERSAL STRESS
PROTEIN E
(Proteus
mirabilis) 		5 / 12 LEU A 233
HIS A 169
LEU A 176
GLY A 270
LEU A 195
 None
 1.31A 3okxB-3olqA:
undetectable		 3okxB-3olqA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 3olq UNIVERSAL STRESS
PROTEIN E
(Proteus
mirabilis) 		4 / 8 LEU A 298
LEU A   7
HIS A 109
ILE A 100
 None
 1.07A 4ok1A-3olqA:
undetectable		 4ok1A-3olqA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 3olq UNIVERSAL STRESS
PROTEIN E
(Proteus
mirabilis) 		3 / 3 LEU A 111
MET A 144
TYR A  26
 None
None
UNL  A 321 ( 3.8A)
 0.74A 4p6xG-3olqA:
undetectable		 4p6xG-3olqA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3olq UNIVERSAL STRESS
PROTEIN E
(Proteus
mirabilis) 		4 / 7 THR A 285
HIS A 226
ASN A 173
SER A 278
 None
 1.06A 4pfjA-3olqA:
2.5		 4pfjA-3olqA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3olq UNIVERSAL STRESS
PROTEIN E
(Proteus
mirabilis) 		4 / 6 THR A 155
GLN A 188
THR A 244
ASN A 181
 None
UNL  A 321 ( 4.2A)
None
None
 1.37A 4pfjB-3olqA:
2.6		 4pfjB-3olqA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 3olq UNIVERSAL STRESS
PROTEIN E
(Proteus
mirabilis) 		4 / 6 ILE A  11
ALA A  20
LEU A  21
ILE A  35
 None
None
UNL  A 321 ( 4.7A)
None
 0.61A 5mvmB-3olqA:
undetectable
5mvmC-3olqA:
undetectable		 5mvmB-3olqA:
16.54
5mvmC-3olqA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_D_ADND502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 3olq UNIVERSAL STRESS
PROTEIN E
(Proteus
mirabilis) 		5 / 12 THR A 128
LYS A 148
ASP A 147
HIS A 117
MET A 115
 None
 1.49A 5v96D-3olqA:
3.5		 5v96D-3olqA:
22.27