SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3olz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 3olz GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3
(Rattus
norvegicus) 		5 / 9 ASP A 134
ALA A 131
GLU A 159
SER A 127
GLY A 382
 None
 1.03A 1bcuH-3olzA:
undetectable		 1bcuH-3olzA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)		 3olz GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3
(Rattus
norvegicus) 		5 / 12 THR A 229
LEU A 361
LEU A 139
ILE A 169
LEU A 160
 None
 1.25A 1errA-3olzA:
undetectable		 1errA-3olzA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 3olz GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3
(Rattus
norvegicus) 		4 / 8 SER A 129
ILE A 132
LEU A 133
LEU A 157
 None
 0.67A 1eupA-3olzA:
undetectable		 1eupA-3olzA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 3olz GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3
(Rattus
norvegicus) 		5 / 12 HIS A  27
ALA A  28
PHE A  29
LEU A 104
ALA A 292
 None
 1.12A 1mjqC-3olzA:
undetectable
1mjqD-3olzA:
undetectable		 1mjqC-3olzA:
13.07
1mjqD-3olzA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 3olz GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3
(Rattus
norvegicus) 		5 / 12 HIS A  27
ALA A  28
PHE A  29
LEU A 104
ALA A 292
 None
 1.12A 1mjqI-3olzA:
undetectable
1mjqJ-3olzA:
undetectable		 1mjqI-3olzA:
13.07
1mjqJ-3olzA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3olz GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3
(Rattus
norvegicus) 		4 / 7 LEU A 361
ILE A 363
ALA A 131
ILE A 199
 None
 0.83A 1oniB-3olzA:
undetectable
1oniC-3olzA:
undetectable		 1oniB-3olzA:
16.84
1oniC-3olzA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 3olz GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3
(Rattus
norvegicus) 		4 / 6 LEU A 160
ILE A 161
PRO A 164
VAL A 246
 None
 1.17A 2ygoA-3olzA:
undetectable		 2ygoA-3olzA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 3olz GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3
(Rattus
norvegicus) 		5 / 12 CYH A 202
THR A 230
THR A 229
ILE A 210
LEU A 157
 None
 1.13A 3gwxA-3olzA:
undetectable		 3gwxA-3olzA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_PNTA901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 3olz GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3
(Rattus
norvegicus) 		5 / 12 TYR A 234
THR A 230
ASP A 232
TYR A 122
GLY A 345
 None
 1.45A 3hiiA-3olzA:
1.5		 3hiiA-3olzA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_PNTB901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 3olz GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3
(Rattus
norvegicus) 		5 / 12 TYR A 234
THR A 230
ASP A 232
TYR A 122
GLY A 345
 None
 1.41A 3hiiB-3olzA:
0.3		 3hiiB-3olzA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3olz GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3
(Rattus
norvegicus) 		5 / 6 HIS A 225
VAL A 146
LEU A 231
ILE A 363
LEU A 157
 NAG  A 400 ( 4.7A)
None
None
None
None
 1.45A 3kk6A-3olzA:
0.2		 3kk6A-3olzA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 3olz GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3
(Rattus
norvegicus) 		5 / 11 THR A 221
LEU A 248
ALA A 214
PHE A 196
THR A 230
 None
 1.45A 3qelA-3olzA:
29.4
3qelB-3olzA:
23.6		 3qelA-3olzA:
23.60
3qelB-3olzA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 3olz GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3
(Rattus
norvegicus) 		5 / 12 CYH A 202
THR A 230
THR A 229
LEU A 236
ILE A 210
 None
 1.17A 3sp9A-3olzA:
undetectable		 3sp9A-3olzA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3olz GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3
(Rattus
norvegicus) 		4 / 7 ILE A  52
GLU A  26
TYR A  13
HIS A  56
 None
 1.07A 4a97D-3olzA:
undetectable		 4a97D-3olzA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3olz GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3
(Rattus
norvegicus) 		5 / 12 ALA A 144
VAL A 146
THR A 249
PHE A 251
ILE A 132
 None
 1.14A 4c49A-3olzA:
undetectable		 4c49A-3olzA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 3olz GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3
(Rattus
norvegicus) 		4 / 5 LEU A 383
ILE A 227
ALA A 131
PHE A 251
 None
 1.05A 4dc3B-3olzA:
3.4		 4dc3B-3olzA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 3olz GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3
(Rattus
norvegicus) 		5 / 12 PHE A 226
LEU A 233
GLY A 250
TYR A 234
ALA A 235
 None
 1.30A 4eb4B-3olzA:
undetectable		 4eb4B-3olzA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3olz GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3
(Rattus
norvegicus) 		5 / 12 CYH A 305
SER A 303
HIS A 300
VAL A 119
LEU A  42
 None
None
None
None
NAG  A 399 ( 3.7A)
 1.44A 4o8fA-3olzA:
0.0		 4o8fA-3olzA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 3olz GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3
(Rattus
norvegicus) 		4 / 7 LEU A 248
ALA A 207
LEU A 236
ILE A 210
 None
 0.72A 4ubsA-3olzA:
undetectable		 4ubsA-3olzA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 3olz GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3
(Rattus
norvegicus) 		5 / 12 THR A 221
LEU A 248
ALA A 214
PHE A 196
THR A 230
 None
 1.45A 5ewjC-3olzA:
29.5
5ewjD-3olzA:
23.8		 5ewjC-3olzA:
24.44
5ewjD-3olzA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 3olz GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3
(Rattus
norvegicus) 		5 / 9 ILE A 102
PRO A 100
LEU A  48
ILE A   5
LEU A 104
 None
 1.16A 5iepA-3olzA:
undetectable		 5iepA-3olzA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3olz GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3
(Rattus
norvegicus) 		4 / 5 CYH A  86
GLN A  83
PRO A  81
ILE A  55
 None
 1.33A 5ki6A-3olzA:
5.6		 5ki6A-3olzA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 3olz GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3
(Rattus
norvegicus) 		5 / 12 VAL A  75
LEU A 295
ALA A  77
ARG A  30
LEU A  48
 None
 1.28A 5nd2B-3olzA:
4.4		 5nd2B-3olzA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 3olz GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3
(Rattus
norvegicus) 		4 / 6 MET A 289
THR A 290
LEU A 254
THR A 230
 None
 1.21A 6mvxA-3olzA:
undetectable
6mvxB-3olzA:
undetectable
6mvxC-3olzA:
undetectable		 6mvxA-3olzA:
21.95
6mvxB-3olzA:
21.95
6mvxC-3olzA:
21.95