SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3om5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 3om5 LEVANSUCRASE
(Bacillus
megaterium) 		4 / 8 LEU A 365
ALA A 354
LEU A 178
THR A 105
 None
 0.87A 1dvtA-3om5A:
undetectable
1dvtB-3om5A:
undetectable		 1dvtA-3om5A:
14.86
1dvtB-3om5A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 3om5 LEVANSUCRASE
(Bacillus
megaterium) 		4 / 8 SER A 192
ASN A 167
ASP A 229
THR A 202
 None
 1.14A 1ig3A-3om5A:
undetectable
1ig3B-3om5A:
undetectable		 1ig3A-3om5A:
18.83
1ig3B-3om5A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 3om5 LEVANSUCRASE
(Bacillus
megaterium) 		3 / 3 SER A 144
THR A 480
GLN A 113
 None
 0.58A 2fk8A-3om5A:
undetectable		 2fk8A-3om5A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3om5 LEVANSUCRASE
(Bacillus
megaterium) 		3 / 3 PRO A 298
ASN A 297
ARG A 290
 None
 1.07A 2qeuB-3om5A:
undetectable		 2qeuB-3om5A:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 3om5 LEVANSUCRASE
(Bacillus
megaterium) 		4 / 6 THR A 375
VAL A 347
LEU A 307
GLU A 303
 None
 1.18A 3b6rB-3om5A:
undetectable		 3b6rB-3om5A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3om5 LEVANSUCRASE
(Bacillus
megaterium) 		5 / 12 SER A 391
LEU A 341
VAL A 270
ILE A 261
LYS A 339
 None
 1.18A 3g9eA-3om5A:
undetectable		 3g9eA-3om5A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB0_A_DIFA701_1
(LACTOTRANSFERRIN)		 3om5 LEVANSUCRASE
(Bacillus
megaterium) 		4 / 4 PRO A 340
TYR A 235
GLY A 276
THR A 277
 None
 1.26A 3ib0A-3om5A:
undetectable		 3ib0A-3om5A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 3om5 LEVANSUCRASE
(Bacillus
megaterium) 		5 / 6 PHE A 357
TYR A 364
VAL A 459
THR A 466
PHE A 366
 None
 1.40A 3ltwA-3om5A:
undetectable		 3ltwA-3om5A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 3om5 LEVANSUCRASE
(Bacillus
megaterium) 		5 / 12 LEU A 323
LEU A 387
GLY A 405
THR A 404
LEU A 365
 None
 1.33A 3okxA-3om5A:
undetectable		 3okxA-3om5A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 3om5 LEVANSUCRASE
(Bacillus
megaterium) 		5 / 12 LEU A 323
LEU A 387
GLY A 405
THR A 404
LEU A 365
 None
 1.27A 3okxB-3om5A:
undetectable		 3okxB-3om5A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		 3om5 LEVANSUCRASE
(Bacillus
megaterium) 		4 / 6 THR A 466
ILE A  46
TYR A 389
ASP A 403
 None
 0.91A 3q70A-3om5A:
undetectable		 3q70A-3om5A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RZE_A_D7VA1201_1
(HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA)		 3om5 LEVANSUCRASE
(Bacillus
megaterium) 		5 / 12 THR A 333
ILE A 227
TYR A 260
PHE A 187
TYR A 268
 None
 1.31A 3rzeA-3om5A:
undetectable		 3rzeA-3om5A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_B_MIYB2001_1
(TETX2 PROTEIN)		 3om5 LEVANSUCRASE
(Bacillus
megaterium) 		4 / 8 GLN A 100
HIS A 259
GLY A 104
ASN A 433
 None
 0.97A 3v3nB-3om5A:
undetectable		 3v3nB-3om5A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_C_MIYC2001_1
(TETX2 PROTEIN)		 3om5 LEVANSUCRASE
(Bacillus
megaterium) 		4 / 8 GLN A 100
HIS A 259
GLY A 104
ASN A 433
 None
 0.98A 3v3nC-3om5A:
undetectable		 3v3nC-3om5A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3om5 LEVANSUCRASE
(Bacillus
megaterium) 		3 / 3 THR A 254
ASN A 274
GLU A 272
 None
CA  A   1 ( 4.8A)
None
 0.74A 3v4tA-3om5A:
undetectable
3v4tC-3om5A:
undetectable		 3v4tA-3om5A:
21.01
3v4tC-3om5A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 3om5 LEVANSUCRASE
(Bacillus
megaterium) 		4 / 5 GLU A 272
GLY A 321
TYR A 235
ASP A 279
 None
 1.04A 3w9tD-3om5A:
undetectable		 3w9tD-3om5A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG502_1
(HEMOLYTIC LECTIN
CEL-III)		 3om5 LEVANSUCRASE
(Bacillus
megaterium) 		4 / 5 ASP A 263
GLU A 262
GLY A 265
TYR A 268
 None
 1.50A 3w9tG-3om5A:
undetectable		 3w9tG-3om5A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 3om5 LEVANSUCRASE
(Bacillus
megaterium) 		5 / 12 ASP A  90
ALA A  79
PHE A 133
ASN A 147
ASP A 448
 None
 1.46A 3welA-3om5A:
undetectable		 3welA-3om5A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEM_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 3om5 LEVANSUCRASE
(Bacillus
megaterium) 		5 / 12 ASP A  90
ALA A  79
PHE A 133
ASN A 147
ASP A 448
 None
 1.44A 3wemA-3om5A:
undetectable		 3wemA-3om5A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 3om5 LEVANSUCRASE
(Bacillus
megaterium) 		5 / 12 ASP A  90
ALA A  79
PHE A 133
ASN A 147
ASP A 448
 None
 1.46A 3weoA-3om5A:
undetectable		 3weoA-3om5A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 3om5 LEVANSUCRASE
(Bacillus
megaterium) 		4 / 8 LEU A  91
ILE A  89
ASN A  87
GLY A  86
 None
 0.84A 3wxoA-3om5A:
undetectable		 3wxoA-3om5A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3om5 LEVANSUCRASE
(Bacillus
megaterium) 		4 / 8 GLN A  57
PHE A  63
ILE A  54
GLY A 388
 None
 0.78A 4fgjA-3om5A:
undetectable
4fgjB-3om5A:
undetectable		 4fgjA-3om5A:
18.06
4fgjB-3om5A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 3om5 LEVANSUCRASE
(Bacillus
megaterium) 		4 / 8 SER A 422
ASP A  95
GLU A 352
THR A 441
 None
P6G  A 485 ( 4.4A)
P6G  A 485 (-3.2A)
None
 1.10A 4lnwA-3om5A:
undetectable		 4lnwA-3om5A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 3om5 LEVANSUCRASE
(Bacillus
megaterium) 		3 / 3 PRO A 427
ASN A 355
HIS A 259
 None
 0.66A 4ma3H-3om5A:
undetectable
4ma3L-3om5A:
undetectable		 4ma3H-3om5A:
19.30
4ma3L-3om5A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_0
(NEURAMINIDASE)		 3om5 LEVANSUCRASE
(Bacillus
megaterium) 		5 / 12 LEU A 118
ALA A 252
GLU A 350
GLU A 352
TYR A 421
 P6G  A 485 ( 4.9A)
None
None
P6G  A 485 (-3.2A)
P6G  A 485 (-4.1A)
 1.45A 4mx0A-3om5A:
10.5		 4mx0A-3om5A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 3om5 LEVANSUCRASE
(Bacillus
megaterium) 		5 / 12 THR A 277
GLY A 280
ASN A 345
ASP A 279
ILE A 234
 None
 1.36A 4pooB-3om5A:
undetectable		 4pooB-3om5A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3om5 LEVANSUCRASE
(Bacillus
megaterium) 		5 / 12 ASP A 231
LEU A 328
GLU A 327
GLY A 324
ALA A 322
 None
 1.07A 4retA-3om5A:
undetectable		 4retA-3om5A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3om5 LEVANSUCRASE
(Bacillus
megaterium) 		5 / 12 ASP A 231
LEU A 328
GLU A 327
GLY A 324
ALA A 322
 None
 1.07A 4retC-3om5A:
undetectable		 4retC-3om5A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3om5 LEVANSUCRASE
(Bacillus
megaterium) 		5 / 12 GLY A 388
THR A 367
ILE A  46
GLN A  57
ILE A  54
 None
 1.17A 4zvmA-3om5A:
undetectable
4zvmB-3om5A:
undetectable		 4zvmA-3om5A:
18.50
4zvmB-3om5A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3om5 LEVANSUCRASE
(Bacillus
megaterium) 		5 / 12 GLY A 388
THR A 367
ILE A  46
GLN A  57
PHE A  63
 None
 0.91A 4zvmA-3om5A:
undetectable
4zvmB-3om5A:
undetectable		 4zvmA-3om5A:
18.50
4zvmB-3om5A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3om5 LEVANSUCRASE
(Bacillus
megaterium) 		3 / 3 GLU A 327
HIS A 266
ASP A 330
 None
 0.87A 5c0oG-3om5A:
undetectable		 5c0oG-3om5A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_A_Z80A401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3om5 LEVANSUCRASE
(Bacillus
megaterium) 		5 / 11 ILE A 142
ILE A  76
PHE A 133
ASP A  92
ALA A 117
 None
 1.15A 5lg3A-3om5A:
undetectable		 5lg3A-3om5A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 3om5 LEVANSUCRASE
(Bacillus
megaterium) 		3 / 3 THR A 237
HIS A 253
ASN A 274
 None
None
CA  A   1 ( 4.8A)
 0.90A 5n4tA-3om5A:
undetectable		 5n4tA-3om5A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_1
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 3om5 LEVANSUCRASE
(Bacillus
megaterium) 		4 / 5 GLY A 294
ARG A 290
ASP A  49
GLN A  56
 None
 1.38A 5ubbA-3om5A:
undetectable		 5ubbA-3om5A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3om5 LEVANSUCRASE
(Bacillus
megaterium) 		5 / 12 GLY A 120
VAL A 206
VAL A 218
GLY A 149
ASN A 147
 None
 0.95A 5vopA-3om5A:
undetectable		 5vopA-3om5A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 3om5 LEVANSUCRASE
(Bacillus
megaterium) 		4 / 5 GLY A 294
ASP A  49
ARG A  48
GLN A 301
 None
 1.29A 5zrfB-3om5A:
undetectable		 5zrfB-3om5A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB7_A_PARA900_0
(AAC(3)-IIIB PROTEIN)		 3om5 LEVANSUCRASE
(Bacillus
megaterium) 		5 / 10 TYR A 292
ASN A  39
THR A 275
GLY A 276
GLU A 278
 None
 1.43A 6mb7A-3om5A:
undetectable		 6mb7A-3om5A:
10.53