SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3om8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 3om8 PROBABLE HYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 188
GLY A 185
LEU A 186
ASP A 135
ALA A 192
 None
 1.13A 1jg2A-3om8A:
undetectable		 1jg2A-3om8A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 3om8 PROBABLE HYDROLASE
(Pseudomonas
aeruginosa) 		4 / 7 VAL A 211
LEU A 237
THR A 239
LEU A 240
 None
 0.98A 1jgsA-3om8A:
undetectable		 1jgsA-3om8A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 3om8 PROBABLE HYDROLASE
(Pseudomonas
aeruginosa) 		6 / 12 GLY A 102
GLY A 105
VAL A  81
LEU A 119
LEU A 108
LEU A  96
 None
 1.42A 1mx1D-3om8A:
13.4		 1mx1D-3om8A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 3om8 PROBABLE HYDROLASE
(Pseudomonas
aeruginosa) 		4 / 8 HIS A 244
GLY A 214
ASN A 247
SER A 246
 None
 0.92A 2a8tB-3om8A:
undetectable		 2a8tB-3om8A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 3om8 PROBABLE HYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  15
LEU A 100
VAL A 104
LEU A  77
ARG A  60
 None
EDO  A 266 (-3.7A)
None
None
None
 1.18A 2bxfB-3om8A:
undetectable		 2bxfB-3om8A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3om8 PROBABLE HYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 232
ALA A 122
GLY A 102
SER A 246
PHE A 254
 None
 1.09A 2okcA-3om8A:
undetectable		 2okcA-3om8A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3om8 PROBABLE HYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 232
ALA A 122
GLY A 102
SER A 246
PHE A 254
 None
 1.06A 2okcB-3om8A:
undetectable		 2okcB-3om8A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3om8 PROBABLE HYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 105
GLY A  97
LEU A 100
ILE A 116
LEU A  82
 None
None
EDO  A 266 (-3.7A)
None
None
 1.10A 2zbpA-3om8A:
2.5		 2zbpA-3om8A:
25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 3om8 PROBABLE HYDROLASE
(Pseudomonas
aeruginosa) 		4 / 8 ALA A 122
PHE A 174
ASN A 123
THR A  36
 None
 1.07A 3t3sE-3om8A:
undetectable		 3t3sE-3om8A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 3om8 PROBABLE HYDROLASE
(Pseudomonas
aeruginosa) 		4 / 7 HIS A 244
LEU A  98
GLY A 214
ALA A 242
 None
 0.95A 3tehB-3om8A:
undetectable		 3tehB-3om8A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 3om8 PROBABLE HYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 176
GLY A  63
ASP A  58
LEU A  38
ALA A 180
 None
 1.02A 4lg1C-3om8A:
undetectable		 4lg1C-3om8A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 3om8 PROBABLE HYDROLASE
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 217
TRP A 134
SER A  99
 None
None
EDO  A 266 (-2.7A)
 0.74A 4lrhB-3om8A:
undetectable		 4lrhB-3om8A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 3om8 PROBABLE HYDROLASE
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 217
TRP A 134
SER A  99
 None
None
EDO  A 266 (-2.7A)
 0.85A 4lrhF-3om8A:
undetectable		 4lrhF-3om8A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA603_1
(SERUM ALBUMIN)		 3om8 PROBABLE HYDROLASE
(Pseudomonas
aeruginosa) 		5 / 11 LEU A  77
ARG A  60
SER A 189
SER A  31
LEU A 100
 None
None
None
None
EDO  A 266 (-3.7A)
 1.21A 4or0A-3om8A:
undetectable		 4or0A-3om8A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 3om8 PROBABLE HYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 102
ASP A  80
VAL A  81
ALA A 109
LEU A 108
 None
 1.03A 5kocA-3om8A:
undetectable		 5kocA-3om8A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 3om8 PROBABLE HYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 102
GLY A  97
LEU A  98
GLY A 188
ASN A  32
 None
 1.09A 6gngB-3om8A:
5.6		 6gngB-3om8A:
20.13