SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3om9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 3om9 LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		6 / 9 GLY A  27
ASP A  53
TYR A  85
ALA A  98
ILE A 119
GLU A 122
 NAD  A 701 ( 4.0A)
NAD  A 701 (-2.9A)
None
NAD  A 701 (-3.4A)
NAD  A 701 (-3.6A)
None
 0.56A 1cetA-3om9A:
44.5		 1cetA-3om9A:
48.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3om9 LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 4 LEU A 202
VAL A 191
CYH A 165
ALA A 164
 None
None
None
NAD  A 701 (-3.7A)
 1.19A 1mz9E-3om9A:
undetectable		 1mz9E-3om9A:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 3om9 LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 7 GLY A 237
ARG A 109
ILE A 239
VAL A 240
 None
OXQ  A 702 (-3.9A)
None
None
 0.92A 1rxcC-3om9A:
undetectable		 1rxcC-3om9A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3om9 LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 7 ILE A 239
TYR A 175
ARG A 174
LEU A 167
 None
None
None
NAD  A 701 (-4.3A)
 0.84A 1v54N-3om9A:
undetectable
1v54W-3om9A:
undetectable		 1v54N-3om9A:
20.12
1v54W-3om9A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3om9 LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 7 ILE A 239
TYR A 175
ARG A 174
LEU A 167
 None
None
None
NAD  A 701 (-4.3A)
 0.89A 1v55A-3om9A:
undetectable
1v55J-3om9A:
undetectable		 1v55A-3om9A:
20.12
1v55J-3om9A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B17_A_DIFA701_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3om9 LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 10 ALA A 254
ILE A  95
GLY A 162
HIS A 195
ASP A 143
 None
None
None
NAD  A 701 ( 3.5A)
None
 1.42A 2b17A-3om9A:
undetectable		 2b17A-3om9A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3om9 LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 7 ILE A 239
TYR A 175
ARG A 174
LEU A 167
 None
None
None
NAD  A 701 (-4.3A)
 0.89A 2dyrN-3om9A:
undetectable
2dyrW-3om9A:
undetectable		 2dyrN-3om9A:
20.12
2dyrW-3om9A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3om9 LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 6 ILE A 239
TYR A 175
ARG A 174
LEU A 167
 None
None
None
NAD  A 701 (-4.3A)
 0.94A 2einN-3om9A:
undetectable
2einW-3om9A:
undetectable		 2einN-3om9A:
20.12
2einW-3om9A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3om9 LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 5 LEU A  51
ALA A  24
ILE A  26
LYS A  62
 None
 1.13A 2othA-3om9A:
undetectable		 2othA-3om9A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3om9 LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 5 VAL A  54
TYR A  85
ILE A  26
ALA A  98
 NAD  A 701 (-4.1A)
None
None
NAD  A 701 (-3.4A)
 0.95A 3n8yB-3om9A:
undetectable		 3n8yB-3om9A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 3om9 LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 7 ALA A  87
VAL A  96
VAL A  94
LEU A  88
 None
 0.83A 3o14A-3om9A:
undetectable		 3o14A-3om9A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VXI_A_ASCA502_0
(DYP)		 3om9 LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 5 ALA A 164
ASN A 140
PRO A 250
HIS A 195
 NAD  A 701 (-3.7A)
OXQ  A 702 ( 3.2A)
NAD  A 701 ( 4.4A)
NAD  A 701 ( 3.5A)
 1.45A 3vxiA-3om9A:
0.0		 3vxiA-3om9A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3om9 LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 6 ILE A 239
TYR A 175
ARG A 174
LEU A 167
 None
None
None
NAD  A 701 (-4.3A)
 0.92A 3wg7N-3om9A:
undetectable
3wg7W-3om9A:
undetectable		 3wg7N-3om9A:
20.12
3wg7W-3om9A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_B_QMRB1214_1
(CAPITELLA TELETA
ACHBP)		 3om9 LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 9 ILE A 303
ILE A 298
PHE A 134
VAL A 292
CYH A 271
 None
 1.01A 4afgA-3om9A:
undetectable
4afgE-3om9A:
undetectable		 4afgA-3om9A:
19.76
4afgE-3om9A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIX_A_NIMA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3om9 LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 4 LEU A  51
ALA A  24
ILE A  26
LYS A  62
 None
 1.18A 4eixA-3om9A:
undetectable		 4eixA-3om9A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3om9 LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 7 GLY A 294
GLY A 297
MET A 159
ASN A 158
 None
 0.98A 4fgkB-3om9A:
4.8		 4fgkB-3om9A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3om9 LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 5 GLY A 295
GLY A 297
MET A 159
ASN A 158
 None
 1.12A 4fglC-3om9A:
4.6		 4fglC-3om9A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3om9 LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 6 GLY A 294
GLY A 297
MET A 159
ASN A 158
 None
 0.92A 4fglD-3om9A:
undetectable		 4fglD-3om9A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3om9 LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 8 ASP A 197
ASP A 143
ASP A 321
ASN A 110
 None
 1.08A 4gkhC-3om9A:
undetectable
4gkhK-3om9A:
undetectable		 4gkhC-3om9A:
22.67
4gkhK-3om9A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3om9 LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 8 ASP A 197
ASP A 143
ASP A 321
ASN A 110
 None
 1.07A 4gkiE-3om9A:
undetectable
4gkiG-3om9A:
undetectable		 4gkiE-3om9A:
22.67
4gkiG-3om9A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3om9 LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		3 / 3 ASP A 111
ASN A 140
SER A 105
 None
OXQ  A 702 ( 3.2A)
None
 0.47A 4obwA-3om9A:
3.8		 4obwA-3om9A:
22.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OKN_B_KANB403_1
(L-LACTATE
DEHYDROGENASE A
CHAIN)		 3om9 LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		6 / 9 ASP A  53
VAL A  54
TYR A  85
ALA A  98
ILE A 119
ILE A 123
 NAD  A 701 (-2.9A)
NAD  A 701 (-4.1A)
None
NAD  A 701 (-3.4A)
NAD  A 701 (-3.6A)
None
 1.16A 4oknB-3om9A:
37.8		 4oknB-3om9A:
30.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 3om9 LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ILE A  95
ALA A 251
THR A  70
VAL A  76
LEU A  51
 None
 1.21A 4qzuA-3om9A:
undetectable		 4qzuA-3om9A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 3om9 LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ILE A  95
ALA A 251
THR A  70
VAL A  76
LEU A  51
 None
 1.20A 4qzuC-3om9A:
undetectable		 4qzuC-3om9A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3om9 LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 PHE A 115
GLY A  99
ALA A  98
ASN A 140
PRO A 114
 None
NAD  A 701 (-4.2A)
NAD  A 701 (-3.4A)
OXQ  A 702 ( 3.2A)
None
 1.11A 4rtpA-3om9A:
undetectable		 4rtpA-3om9A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 3om9 LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		3 / 3 TYR A 205
THR A 207
THR A 190
 None
 0.68A 5aoxB-3om9A:
undetectable		 5aoxB-3om9A:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 3om9 LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		3 / 3 TYR A 205
THR A 207
THR A 190
 None
 0.64A 5aoxE-3om9A:
undetectable		 5aoxE-3om9A:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3om9 LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 7 ILE A 239
TYR A 175
ARG A 174
LEU A 167
 None
None
None
NAD  A 701 (-4.3A)
 0.93A 5b3sN-3om9A:
undetectable
5b3sW-3om9A:
undetectable		 5b3sN-3om9A:
20.12
5b3sW-3om9A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 3om9 LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ASN A 110
ASP A 143
LEU A 281
PHE A 315
ILE A 287
 None
 1.06A 5dv4A-3om9A:
undetectable		 5dv4A-3om9A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3om9 LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 7 ILE A 239
TYR A 175
ARG A 174
LEU A 167
 None
None
None
NAD  A 701 (-4.3A)
 0.90A 5iy5A-3om9A:
undetectable
5iy5J-3om9A:
undetectable		 5iy5A-3om9A:
20.12
5iy5J-3om9A:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3om9 LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 6 GLY A  37
TYR A  38
LEU A  45
VAL A  76
 None
 0.98A 5x80A-3om9A:
undetectable
5x80B-3om9A:
undetectable		 5x80A-3om9A:
20.86
5x80B-3om9A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3om9 LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 7 ILE A 239
TYR A 175
ARG A 174
LEU A 167
 None
None
None
NAD  A 701 (-4.3A)
 0.88A 5xdqN-3om9A:
0.7
5xdqW-3om9A:
undetectable		 5xdqN-3om9A:
20.12
5xdqW-3om9A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 3om9 LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 8 ILE A 239
TYR A 175
ARG A 174
LEU A 167
 None
None
None
NAD  A 701 (-4.3A)
 0.91A 5xdxN-3om9A:
undetectable
5xdxW-3om9A:
undetectable		 5xdxN-3om9A:
20.12
5xdxW-3om9A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3om9 LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 6 ILE A 239
TYR A 175
ARG A 174
LEU A 167
 None
None
None
NAD  A 701 (-4.3A)
 0.95A 5z86N-3om9A:
undetectable
5z86W-3om9A:
undetectable		 5z86N-3om9A:
20.12
5z86W-3om9A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3om9 LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 6 ILE A 239
TYR A 175
ARG A 174
LEU A 167
 None
None
None
NAD  A 701 (-4.3A)
 0.96A 5zcoN-3om9A:
undetectable
5zcoW-3om9A:
undetectable		 5zcoN-3om9A:
20.12
5zcoW-3om9A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 3om9 LACTATE
DEHYDROGENASE
(Toxoplasma
gondii) 		3 / 3 LEU A 262
SER A 260
PHE A 261
 None
 0.65A 6fgcA-3om9A:
2.5		 6fgcA-3om9A:
23.11