SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ome'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 3ome ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 VAL A 143
TRP A 118
HIS A 148
LEU A 161
 None
 0.82A 1pk2A-3omeA:
undetectable		 1pk2A-3omeA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 3ome ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 116
GLY A 113
GLN A  25
LEU A  92
VAL A 135
 None
 1.44A 2w8yA-3omeA:
undetectable		 2w8yA-3omeA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_2
(ADENOSYLHOMOCYSTEINA
SE)		 3ome ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 THR A 175
GLU A 151
HIS A 146
 None
 0.68A 3g1uB-3omeA:
undetectable		 3g1uB-3omeA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3ome ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 ILE A  50
ARG A 192
ARG A  52
MET A   0
 None
 1.22A 4f4dA-3omeA:
undetectable		 4f4dA-3omeA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3ome ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ILE A  50
ARG A 192
ARG A  52
MET A   0
 None
 1.29A 4f4dB-3omeA:
undetectable		 4f4dB-3omeA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3ome ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ARG A  85
ASN A  26
ASP A  31
GLU A  32
 None
 1.12A 4gkhF-3omeA:
undetectable		 4gkhF-3omeA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 3ome ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ALA A  36
GLN A  25
GLY A  61
 None
 0.52A 4odoC-3omeA:
undetectable		 4odoC-3omeA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 3ome ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ILE A 198
VAL A  48
ILE A  50
THR A 191
 None
 0.70A 4xdtA-3omeA:
undetectable		 4xdtA-3omeA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		 3ome ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 LYS A  99
ILE A  49
ILE A  14
 None
 0.67A 4y0qA-3omeA:
undetectable		 4y0qA-3omeA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA410_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3ome ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
smegmatis) 		4 / 4 GLY A 112
LEU A 115
VAL A 143
GLU A 144
 None
None
None
ZN  A 300 (-3.1A)
 1.25A 5yw0A-3omeA:
undetectable		 5yw0A-3omeA:
20.24