SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3oml'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_B_CCSB417_0
(ESTROGEN RECEPTOR)		 3oml PEROXISOMAL
MULTIFUNCTIONAL
ENZYME TYPE 2,
CG3415
(Drosophila
melanogaster) 		4 / 6 PRO A 356
PHE A 359
GLU A 396
VAL A 398
 None
 0.94A 1l2iB-3omlA:
undetectable		 1l2iB-3omlA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3oml PEROXISOMAL
MULTIFUNCTIONAL
ENZYME TYPE 2,
CG3415
(Drosophila
melanogaster) 		4 / 7 VAL A 527
VAL A 360
LEU A 361
LEU A 523
 None
 0.73A 1pthA-3omlA:
undetectable		 1pthA-3omlA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3oml PEROXISOMAL
MULTIFUNCTIONAL
ENZYME TYPE 2,
CG3415
(Drosophila
melanogaster) 		4 / 7 VAL A 527
VAL A 360
LEU A 361
LEU A 523
 None
 0.72A 1pthB-3omlA:
undetectable		 1pthB-3omlA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 3oml PEROXISOMAL
MULTIFUNCTIONAL
ENZYME TYPE 2,
CG3415
(Drosophila
melanogaster) 		5 / 11 LEU A 467
VAL A 426
THR A 445
HIS A 390
GLN A 367
 None
 1.38A 1tw4A-3omlA:
1.4		 1tw4A-3omlA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_1
(POL POLYPROTEIN)		 3oml PEROXISOMAL
MULTIFUNCTIONAL
ENZYME TYPE 2,
CG3415
(Drosophila
melanogaster) 		5 / 12 GLY A  69
ASP A  63
VAL A  62
VAL A  39
ILE A  65
 None
 1.02A 2f81A-3omlA:
undetectable		 2f81A-3omlA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_1
(POL POLYPROTEIN)		 3oml PEROXISOMAL
MULTIFUNCTIONAL
ENZYME TYPE 2,
CG3415
(Drosophila
melanogaster) 		5 / 12 GLY A  69
ASP A  63
VAL A  62
VAL A  39
ILE A  65
 None
 1.00A 2f8gA-3omlA:
undetectable		 2f8gA-3omlA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 3oml PEROXISOMAL
MULTIFUNCTIONAL
ENZYME TYPE 2,
CG3415
(Drosophila
melanogaster) 		4 / 7 ILE A 149
CYH A 229
ILE A 240
ILE A 195
 None
 0.89A 2q83A-3omlA:
undetectable		 2q83A-3omlA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_2
(PROTEASE RETROPEPSIN)		 3oml PEROXISOMAL
MULTIFUNCTIONAL
ENZYME TYPE 2,
CG3415
(Drosophila
melanogaster) 		5 / 12 GLY A  69
ASP A  63
VAL A  62
VAL A  39
ILE A  65
 None
 1.02A 2qhcB-3omlA:
undetectable		 2qhcB-3omlA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 3oml PEROXISOMAL
MULTIFUNCTIONAL
ENZYME TYPE 2,
CG3415
(Drosophila
melanogaster) 		4 / 9 ILE A 150
ALA A 222
VAL A 225
CYH A 229
 None
 0.95A 2vufB-3omlA:
undetectable		 2vufB-3omlA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3oml PEROXISOMAL
MULTIFUNCTIONAL
ENZYME TYPE 2,
CG3415
(Drosophila
melanogaster) 		4 / 7 TYR A 328
ALA A 334
THR A 483
LEU A 517
 None
 0.95A 2wx2A-3omlA:
undetectable		 2wx2A-3omlA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_1
(HIV-1 PROTEASE)		 3oml PEROXISOMAL
MULTIFUNCTIONAL
ENZYME TYPE 2,
CG3415
(Drosophila
melanogaster) 		5 / 12 GLY A  69
ASP A  63
VAL A  62
VAL A  39
ILE A  65
 None
 1.07A 3d20A-3omlA:
undetectable		 3d20A-3omlA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		 3oml PEROXISOMAL
MULTIFUNCTIONAL
ENZYME TYPE 2,
CG3415
(Drosophila
melanogaster) 		4 / 7 TYR A 227
GLU A 231
LEU A 228
ASN A 193
 None
 1.16A 3k8mA-3omlA:
undetectable		 3k8mA-3omlA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_2
(PROTEASE)		 3oml PEROXISOMAL
MULTIFUNCTIONAL
ENZYME TYPE 2,
CG3415
(Drosophila
melanogaster) 		5 / 10 GLY A  69
ASP A  63
VAL A  62
VAL A  39
ILE A  65
 None
 1.07A 3nu6B-3omlA:
undetectable		 3nu6B-3omlA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3oml PEROXISOMAL
MULTIFUNCTIONAL
ENZYME TYPE 2,
CG3415
(Drosophila
melanogaster) 		5 / 12 GLY A 463
ALA A 462
SER A 429
ASP A 415
GLN A 367
 None
 1.10A 4rtpA-3omlA:
undetectable		 4rtpA-3omlA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 3oml PEROXISOMAL
MULTIFUNCTIONAL
ENZYME TYPE 2,
CG3415
(Drosophila
melanogaster) 		4 / 6 SER A 263
LEU A 264
ASP A 265
LEU A 306
 None
 0.79A 4wozA-3omlA:
undetectable
4wozB-3omlA:
undetectable		 4wozA-3omlA:
20.45
4wozB-3omlA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 3oml PEROXISOMAL
MULTIFUNCTIONAL
ENZYME TYPE 2,
CG3415
(Drosophila
melanogaster) 		4 / 7 VAL A 196
GLU A 241
ASN A 179
VAL A 194
 None
 1.14A 5jh7C-3omlA:
5.1		 5jh7C-3omlA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 3oml PEROXISOMAL
MULTIFUNCTIONAL
ENZYME TYPE 2,
CG3415
(Drosophila
melanogaster) 		5 / 12 VAL A  79
LEU A 106
SER A 130
GLY A  25
LEU A  24
 None
 1.26A 5m50E-3omlA:
5.9		 5m50E-3omlA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_1
(METHYLTRANSFERASE)		 3oml PEROXISOMAL
MULTIFUNCTIONAL
ENZYME TYPE 2,
CG3415
(Drosophila
melanogaster) 		4 / 4 SER A 284
THR A 406
ASP A 433
ASP A 316
 None
 1.29A 5vimA-3omlA:
2.1		 5vimA-3omlA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_1
(METHYLTRANSFERASE)		 3oml PEROXISOMAL
MULTIFUNCTIONAL
ENZYME TYPE 2,
CG3415
(Drosophila
melanogaster) 		4 / 4 SER A 284
THR A 406
ASP A 433
ASP A 316
 None
 1.26A 5vimB-3omlA:
2.1		 5vimB-3omlA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3oml PEROXISOMAL
MULTIFUNCTIONAL
ENZYME TYPE 2,
CG3415
(Drosophila
melanogaster) 		4 / 7 GLY A 519
THR A 522
ARG A 548
SER A 585
 None
 0.76A 6jnhA-3omlA:
undetectable		 6jnhA-3omlA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3oml PEROXISOMAL
MULTIFUNCTIONAL
ENZYME TYPE 2,
CG3415
(Drosophila
melanogaster) 		4 / 6 GLY A 519
THR A 522
ARG A 548
SER A 585
 None
 0.79A 6jogA-3omlA:
undetectable		 6jogA-3omlA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		 3oml PEROXISOMAL
MULTIFUNCTIONAL
ENZYME TYPE 2,
CG3415
(Drosophila
melanogaster) 		4 / 4 HIS A 126
LEU A  24
TYR A  28
GLY A  19
 None
 1.39A 6n91A-3omlA:
undetectable		 6n91A-3omlA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_1
(ADENOSINE DEAMINASE)		 3oml PEROXISOMAL
MULTIFUNCTIONAL
ENZYME TYPE 2,
CG3415
(Drosophila
melanogaster) 		4 / 4 HIS A 126
LEU A  24
TYR A  28
GLY A  19
 None
 1.39A 6n91B-3omlA:
undetectable		 6n91B-3omlA:
8.92