SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3on4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3on4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Legionella
pneumophila) 		4 / 8 LYS A  82
GLN A  86
PHE A  89
LEU A 135
 None
 0.93A 1v54P-3on4A:
undetectable
1v54W-3on4A:
undetectable		 1v54P-3on4A:
19.85
1v54W-3on4A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3on4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Legionella
pneumophila) 		4 / 7 LYS A  82
GLN A  86
PHE A  89
LEU A 135
 None
 1.03A 1v55C-3on4A:
undetectable
1v55J-3on4A:
undetectable		 1v55C-3on4A:
19.85
1v55J-3on4A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3on4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Legionella
pneumophila) 		4 / 7 LYS A  82
GLN A  86
PHE A  89
LEU A 135
 None
 0.93A 1v55P-3on4A:
2.4
1v55W-3on4A:
undetectable		 1v55P-3on4A:
19.85
1v55W-3on4A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3on4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Legionella
pneumophila) 		4 / 8 LYS A  82
GLN A  86
PHE A  89
LEU A 135
 None
 0.89A 2dyrP-3on4A:
2.4
2dyrW-3on4A:
undetectable		 2dyrP-3on4A:
19.85
2dyrW-3on4A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3on4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Legionella
pneumophila) 		4 / 7 LYS A  82
GLN A  86
PHE A  89
LEU A 135
 None
 1.02A 2dysP-3on4A:
2.4
2dysW-3on4A:
undetectable		 2dysP-3on4A:
19.85
2dysW-3on4A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3on4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Legionella
pneumophila) 		4 / 7 LYS A  82
GLN A  86
PHE A  89
LEU A 135
 None
 1.07A 2eijC-3on4A:
2.4
2eijJ-3on4A:
undetectable		 2eijC-3on4A:
19.85
2eijJ-3on4A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3on4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Legionella
pneumophila) 		4 / 7 LYS A  82
GLN A  86
PHE A  89
LEU A 135
 None
 0.88A 2eijP-3on4A:
undetectable
2eijW-3on4A:
undetectable		 2eijP-3on4A:
19.85
2eijW-3on4A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3on4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Legionella
pneumophila) 		4 / 8 LYS A  82
GLN A  86
PHE A  89
LEU A 135
 None
 0.90A 2eikP-3on4A:
2.4
2eikW-3on4A:
undetectable		 2eikP-3on4A:
19.85
2eikW-3on4A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3on4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Legionella
pneumophila) 		4 / 7 LYS A  82
GLN A  86
PHE A  89
LEU A 135
 None
 1.02A 2eimC-3on4A:
2.7
2eimJ-3on4A:
undetectable		 2eimC-3on4A:
19.85
2eimJ-3on4A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 3on4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Legionella
pneumophila) 		5 / 12 VAL A 138
ILE A 157
ILE A 156
PHE A  88
LEU A  70
 None
 1.29A 2ft9A-3on4A:
undetectable		 2ft9A-3on4A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 3on4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Legionella
pneumophila) 		4 / 7 ASP A  90
VAL A 179
ARG A 180
ILE A 183
 None
 0.82A 2yfbA-3on4A:
undetectable		 2yfbA-3on4A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 3on4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Legionella
pneumophila) 		4 / 6 ASP A  90
VAL A 179
ARG A 180
ILE A 183
 None
 0.77A 2yfbB-3on4A:
2.1		 2yfbB-3on4A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3on4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Legionella
pneumophila) 		4 / 7 LYS A  82
GLN A  86
PHE A  89
LEU A 135
 None
 0.96A 2zxwC-3on4A:
undetectable
2zxwJ-3on4A:
undetectable		 2zxwC-3on4A:
19.85
2zxwJ-3on4A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 3on4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Legionella
pneumophila) 		5 / 10 ALA A  91
ILE A  92
ILE A 157
LEU A 135
ILE A 131
 None
 1.27A 4dtaA-3on4A:
undetectable		 4dtaA-3on4A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 3on4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Legionella
pneumophila) 		4 / 6 PRO A 117
ILE A  59
TYR A  25
PHE A 109
 None
 1.16A 4g10A-3on4A:
undetectable		 4g10A-3on4A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 3on4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Legionella
pneumophila) 		4 / 7 TYR A  25
ILE A 120
LEU A 105
GLY A 106
 None
 0.82A 4iqqA-3on4A:
undetectable		 4iqqA-3on4A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 3on4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Legionella
pneumophila) 		4 / 8 TYR A  25
ILE A 120
LEU A 105
GLY A 106
 None
 0.77A 4iqqD-3on4A:
undetectable		 4iqqD-3on4A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 3on4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Legionella
pneumophila) 		5 / 9 LEU A 164
ARG A 168
SER A  99
LEU A  95
ILE A  92
 None
 1.26A 4ubsA-3on4A:
undetectable		 4ubsA-3on4A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3on4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Legionella
pneumophila) 		4 / 7 HIS A  62
ILE A  59
VAL A  58
GLN A  21
 None
 1.23A 5kkzC-3on4A:
undetectable
5kkzE-3on4A:
undetectable		 5kkzC-3on4A:
23.53
5kkzE-3on4A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3on4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Legionella
pneumophila) 		4 / 7 HIS A  62
ILE A  59
VAL A  58
GLN A  21
 None
 1.20A 5kkzK-3on4A:
undetectable
5kkzQ-3on4A:
undetectable		 5kkzK-3on4A:
16.86
5kkzQ-3on4A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3on4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Legionella
pneumophila) 		4 / 7 HIS A  62
ILE A  59
VAL A  58
GLN A  21
 None
 1.23A 5kkzM-3on4A:
undetectable
5kkzO-3on4A:
undetectable		 5kkzM-3on4A:
23.53
5kkzO-3on4A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 3on4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Legionella
pneumophila) 		5 / 10 LEU A  95
LEU A 176
GLY A 106
GLY A 163
VAL A 160
 None
 1.16A 6eu9B-3on4A:
undetectable		 6eu9B-3on4A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3on4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Legionella
pneumophila) 		4 / 6 LYS A  82
GLN A  86
PHE A  89
LEU A 135
 None
 1.00A 6nmpC-3on4A:
2.6
6nmpJ-3on4A:
undetectable		 6nmpC-3on4A:
19.85
6nmpJ-3on4A:
16.23